We use cookies to enhance the usability of our website. If you continue, we'll assume that you are happy to receive all cookies. More information. Don't show this again.
Most cancer tissues showed weak to moderate cytoplasmic positivity. Several papillary adenocarcinomas of thyroid, isolated cases of melanomas and single case of cholangiocarcinoma displayed strong staining.
GENE INFORMATION
Gene name
KAT2A (HGNC Symbol)
Synonyms
GCN5, GCN5L2, PCAF-b
Description
K(lysine) acetyltransferase 2A (HGNC Symbol)
Entrez gene summary
KAT2A, or GCN5, is a histone acetyltransferase (HAT) that functions primarily as a transcriptional activator. It also functions as a repressor of NF-kappa-B (see MIM 164011) by promoting ubiquitination of the NF-kappa-B subunit RELA (MIM 164014) in a HAT-independent manner (Mao et al., 2009 [PubMed 19339690]).[supplied by OMIM, Sep 2009]