Tissue expression of EZH1 - Summary - The Human Protein Atlas

GENERAL INFORMATION
Gene name	EZH1
Gene description	Enhancer of zeste 1 polycomb repressive complex 2 subunit
Protein class	Cancer-related genes Enzymes Predicted intracellular proteins
Predicted localization	Intracellular
Number of transcripts	9
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HUMAN PROTEIN ATLAS INFORMATION

RNA tissue category

HPA:	Expressed in all
GTEx:	Expressed in all
FANTOM5:	Expressed in all

Protein evidence

Evidence at protein level

DATA RELIABILITY
Reliability score	Pending normal tissue annotation.

RNA AND PROTEIN EXPRESSION SUMMARY

RNA expression (TPM)

Protein expression (score)

Brain

N/A

Cerebral cortex

N/A

Hippocampus

N/A

Caudate

N/A

Cerebellum

N/A

Endocrine tissues

N/A

Thyroid gland

N/A

Parathyroid gland

N/A

Adrenal gland

N/A

Bone marrow & immune system

N/A

Appendix

N/A

Bone marrow

N/A

Lymph node

N/A

Tonsil

N/A

Spleen

N/A

Muscle tissues

N/A

Heart muscle

N/A

Skeletal muscle

N/A

Smooth muscle

N/A

Lung

N/A

Nasopharynx

N/A

Bronchus

N/A

Lung

N/A

Liver & gallbladder

N/A

Liver

N/A

Gallbladder

N/A

Pancreas

N/A

Pancreas

N/A

Gastrointestinal tract

N/A

Oral mucosa

N/A

Salivary gland

N/A

Esophagus

N/A

Stomach

N/A

Duodenum

N/A

Small intestine

N/A

Colon

N/A

Rectum

N/A

Kidney & urinary bladder

N/A

Kidney

N/A

Urinary bladder

N/A

Male tissues

N/A

Testis

N/A

Epididymis

N/A

Prostate

N/A

Seminal vesicle

N/A

Female tissues

N/A

Breast

N/A

Vagina

N/A

Cervix, uterine

N/A

Endometrium

N/A

Fallopian tube

N/A

Ovary

N/A

Placenta

N/A

Adipose & soft tissue

N/A

Adipose tissue

N/A

Soft tissue

N/A

Skin

N/A

Skin

N/A

PROTEIN EXPRESSION OVERVIEW
Pending normal tissue annotation.

RNA EXPRESSION OVERVIEW
HPA dataset Organ Expression Alphabetical RNA tissue category: Expressed in all
GTEx dataset Organ Expression Alphabetical RNA tissue category: Expressed in all
FANTOM5 dataset Organ Expression Alphabetical RNA tissue category: Expressed in all

GENE INFORMATION
Gene name	EZH1 (HGNC Symbol)
Synonyms	KIAA0388, KMT6B
Description	Enhancer of zeste 1 polycomb repressive complex 2 subunit (HGNC Symbol)
Entrez gene summary	EZH1 is a component of a noncanonical Polycomb repressive complex-2 (PRC2) that mediates methylation of histone H3 (see MIM 602812) lys27 (H3K27) and functions in the maintenance of embryonic stem cell pluripotency and plasticity (Shen et al., 2008 [PubMed 19026780]).[supplied by OMIM, Mar 2009]
Chromosome	17
Cytoband	q21.2
Chromosome location (bp)	42700275 - 42745049
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000108799 (version 83.38)
Entrez gene	2145
UniProt	Q92800 (UniProt - Evidence at protein level)
neXtProt	NX_Q92800
Antibodypedia	EZH1 antibodies

PROTEIN BROWSER

EZH1-001	EZH1-002	EZH1-003	EZH1-004	EZH1-006	EZH1-007	EZH1-013	EZH1-014	EZH1-015

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
EZH1-001 ENSP00000407869 ENST00000415827	A0A0A0MSY9 [Direct mapping] Histone-lysine N-methyltransferase EZH1 Show all	Predicted intracellular proteins Cancer-related genes Mutated cancer genes Protein evidence (Ezkurdia et al 2014) Show all	GO:0005515 [protein binding] GO:0018024 [histone-lysine N-methyltransferase activity] GO:0034968 [histone lysine methylation] Show all	738 aa 84.3 kDa	No	0
EZH1-002 ENSP00000466924 ENST00000592743	Q92800 [Direct mapping] Histone-lysine N-methyltransferase EZH1 Show all	Enzymes ENZYME proteins Transferases Predicted intracellular proteins Cancer-related genes Mutated cancer genes Protein evidence (Ezkurdia et al 2014) Show all	GO:0005515 [protein binding] GO:0005654 [nucleoplasm] GO:0006351 [transcription, DNA-templated] GO:0009653 [anatomical structure morphogenesis] GO:0018024 [histone-lysine N-methyltransferase activity] GO:0034968 [histone lysine methylation] GO:0035098 [ESC/E(Z) complex] Show all	747 aa 85.3 kDa	No	0
EZH1-003 ENSP00000464753 ENST00000586382	K7EIH5 [Direct mapping] Histone-lysine N-methyltransferase EZH1 Show all	Predicted intracellular proteins Cancer-related genes Mutated cancer genes Protein evidence (Ezkurdia et al 2014) Show all	GO:0005654 [nucleoplasm] GO:0018024 [histone-lysine N-methyltransferase activity] GO:0034968 [histone lysine methylation] Show all	296 aa 34.2 kDa	No	0
EZH1-004 ENSP00000404658 ENST00000428826	Q92800 [Direct mapping] Histone-lysine N-methyltransferase EZH1 Show all	Enzymes ENZYME proteins Transferases Predicted intracellular proteins Cancer-related genes Mutated cancer genes Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0003682 [chromatin binding] GO:0005515 [protein binding] GO:0005634 [nucleus] GO:0005654 [nucleoplasm] GO:0006351 [transcription, DNA-templated] GO:0009653 [anatomical structure morphogenesis] GO:0018024 [histone-lysine N-methyltransferase activity] GO:0021766 [hippocampus development] GO:0034968 [histone lysine methylation] GO:0035098 [ESC/E(Z) complex] GO:0045944 [positive regulation of transcription from RNA polymerase II promoter] Show all	747 aa 85.3 kDa	No	0
EZH1-006 ENSP00000465220 ENST00000590078	Q92800 [Direct mapping] Histone-lysine N-methyltransferase EZH1 Show all	Enzymes ENZYME proteins Transferases Predicted intracellular proteins Cancer-related genes Mutated cancer genes Protein evidence (Ezkurdia et al 2014) Show all	GO:0005515 [protein binding] GO:0005654 [nucleoplasm] GO:0006351 [transcription, DNA-templated] GO:0009653 [anatomical structure morphogenesis] GO:0018024 [histone-lysine N-methyltransferase activity] GO:0034968 [histone lysine methylation] GO:0035098 [ESC/E(Z) complex] Show all	677 aa 77 kDa	No	0
EZH1-007 ENSP00000467871 ENST00000585893	Q92800 [Direct mapping] Histone-lysine N-methyltransferase EZH1 Show all	Enzymes ENZYME proteins Transferases Predicted intracellular proteins Cancer-related genes Mutated cancer genes Protein evidence (Ezkurdia et al 2014) Show all	GO:0005515 [protein binding] GO:0005654 [nucleoplasm] GO:0006351 [transcription, DNA-templated] GO:0009653 [anatomical structure morphogenesis] GO:0018024 [histone-lysine N-methyltransferase activity] GO:0034968 [histone lysine methylation] GO:0035098 [ESC/E(Z) complex] Show all	707 aa 80.7 kDa	No	0
EZH1-013 ENSP00000467320 ENST00000593214	K7EPC0 [Direct mapping] Histone-lysine N-methyltransferase EZH1 Show all	Predicted intracellular proteins Cancer-related genes Mutated cancer genes Protein evidence (Ezkurdia et al 2014) Show all	GO:0018024 [histone-lysine N-methyltransferase activity] GO:0034968 [histone lysine methylation] Show all	166 aa 19.4 kDa	No	0
EZH1-014 ENSP00000465482 ENST00000592492	K7EK66 [Direct mapping] Histone-lysine N-methyltransferase EZH1 Show all	Predicted intracellular proteins Cancer-related genes Mutated cancer genes Protein evidence (Ezkurdia et al 2014) Show all	GO:0018024 [histone-lysine N-methyltransferase activity] GO:0034968 [histone lysine methylation] Show all	106 aa 12.3 kDa	No	0
EZH1-015 ENSP00000466393 ENST00000586089	K7EM79 [Direct mapping] Histone-lysine N-methyltransferase EZH1 Show all	Predicted intracellular proteins Cancer-related genes Mutated cancer genes Protein evidence (Ezkurdia et al 2014) Show all	GO:0018024 [histone-lysine N-methyltransferase activity] GO:0034968 [histone lysine methylation] Show all	170 aa 19.6 kDa	No	0