Cell atlas - DLX4 - The Human Protein Atlas

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DLX4

TISSUE

CELL

PATHOLOGY

CELL ATLAS RNA EXPRESSION HUMAN CELLS

GENE/PROTEIN

Antibody validation

Dictionary
	Nucleoplasm

Human cell
	Nucleoplasm

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GENERAL INFORMATION
Gene name	DLX4
Gene description	Distal-less homeobox 4
Protein class	Predicted intracellular proteins Transcription factors
Predicted localization	Intracellular
Number of transcripts	3
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HUMAN PROTEIN ATLAS INFORMATION
Summary	Localized to the nucleoplasm.
RNA cell category	Cell line enhanced (BEWO, CACO-2, K-562)
Protein evidence	Evidence at protein level
Main location	Localized to the Nucleoplasm (approved)

DATA RELIABILITY
Reliability score	Approved based on 1 antibody. HPA059933
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ASSAYS

RNA EXPRESSION OVERVIEW
RNA cell line category: Cell line enhanced (BEWO, CACO-2, K-562) Organ Origin Category Expression Alphabetical Cell lines sorted after organ of phenotypic resemblance. Cell lines sorted after biological source for establishment. Cell lines sorted after the cell line category according to Cellosaurus. Cell lines sorted on descending RNA expression. Cell lines sorted alphabetically.

HUMAN CELLS

Summary

Localized to the nucleoplasm.

Main location

Nucleoplasm (approved)


	Toggle channels	Low High G1 S G2 M N/A

Thumbnail	Antibody	Cell line	Location	Single-cell variation	Cell cycle dependent variation
	HPA059933	CACO-2	No staining
	HPA059933	HEK 293	Nucleoplasm
	HPA059933	U-2 OS	Nucleoplasm

GENE INFORMATION
Gene name	DLX4 (HGNC Symbol)
Synonyms	BP1, DLX7, DLX8, DLX9
Description	Distal-less homeobox 4 (HGNC Symbol)
Entrez gene summary	Many vertebrate homeo box-containing genes have been identified on the basis of their sequence similarity with Drosophila developmental genes. Members of the Dlx gene family contain a homeobox that is related to that of Distal-less (Dll), a gene expressed in the head and limbs of the developing fruit fly. The Distal-less (Dlx) family of genes comprises at least 6 different members, DLX1-DLX6. The DLX proteins are postulated to play a role in forebrain and craniofacial development. Three transcript variants have been described for this gene, however, the full length nature of one variant has not been described. Studies of the two splice variants revealed that one encoded isoform functions as a repressor of the beta-globin gene while the other isoform lacks that function. [provided by RefSeq, Jul 2008]
Chromosome	17
Cytoband	q21.33
Chromosome location (bp)	49968970 - 49974959
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000108813 (version 83.38)
Entrez gene	1748
UniProt	Q92988 (UniProt - Evidence at protein level)
neXtProt	NX_Q92988
Antibodypedia	DLX4 antibodies

PROTEIN BROWSER

DLX4-001	DLX4-003	DLX4-006

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
DLX4-001 ENSP00000240306 ENST00000240306	Q92988 [Direct mapping] Homeobox protein DLX-4 Show all	Predicted intracellular proteins Transcription factors Helix-turn-helix domains Show all	GO:0000122 [negative regulation of transcription from RNA polymerase II promoter] GO:0000978 [RNA polymerase II core promoter proximal region sequence-specific DNA binding] GO:0001078 [transcriptional repressor activity, RNA polymerase II core promoter proximal region sequence-specific binding] GO:0003677 [DNA binding] GO:0003700 [transcription factor activity, sequence-specific DNA binding] GO:0005515 [protein binding] GO:0005634 [nucleus] GO:0006355 [regulation of transcription, DNA-templated] GO:0007275 [multicellular organismal development] GO:0043565 [sequence-specific DNA binding] Show all	240 aa 26.3 kDa	No	0
DLX4-003 ENSP00000410622 ENST00000411890	Q92988 [Direct mapping] Homeobox protein DLX-4 Show all	Phobius predicted secreted proteins Predicted intracellular proteins Transcription factors Helix-turn-helix domains Show all	GO:0000122 [negative regulation of transcription from RNA polymerase II promoter] GO:0000978 [RNA polymerase II core promoter proximal region sequence-specific DNA binding] GO:0001078 [transcriptional repressor activity, RNA polymerase II core promoter proximal region sequence-specific binding] GO:0003677 [DNA binding] GO:0003700 [transcription factor activity, sequence-specific DNA binding] GO:0005515 [protein binding] GO:0005634 [nucleus] GO:0006355 [regulation of transcription, DNA-templated] GO:0007275 [multicellular organismal development] GO:0043565 [sequence-specific DNA binding] Show all	168 aa 18.9 kDa	No	0
DLX4-006 ENSP00000480366 ENST00000611342	Q92988 [Direct mapping] Homeobox protein DLX-4 Show all	Phobius predicted secreted proteins Predicted intracellular proteins Transcription factors Helix-turn-helix domains Show all	GO:0000122 [negative regulation of transcription from RNA polymerase II promoter] GO:0000978 [RNA polymerase II core promoter proximal region sequence-specific DNA binding] GO:0001078 [transcriptional repressor activity, RNA polymerase II core promoter proximal region sequence-specific binding] GO:0003677 [DNA binding] GO:0003700 [transcription factor activity, sequence-specific DNA binding] GO:0005515 [protein binding] GO:0005634 [nucleus] GO:0006355 [regulation of transcription, DNA-templated] GO:0007275 [multicellular organismal development] GO:0043565 [sequence-specific DNA binding] Show all	114 aa 12.7 kDa	No	0

Contact

contact@proteinatlas.org

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.