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Cancer tissues generally displayed moderate cytoplasmic immunoreactivity. Several cases of squamous cell carcinomas, gliomas and lymphomas were weakly stained or negative.
GENE INFORMATION
Gene name
PPP1R9B (HGNC Symbol)
Synonyms
PPP1R6, PPP1R9, SPINO, Spn
Description
Protein phosphatase 1, regulatory subunit 9B (HGNC Symbol)
Entrez gene summary
This gene encodes a scaffold protein that functions as a regulatory subunit of protein phosphatase 1a. Expression of this gene is particularly high in dendritic spines, suggesting that the encoded protein may play a role in receiving signals from the central nervous system. The encoded protein has putative tumor suppressor function and decreased expression has been observed in tumors. [provided by RefSeq, Feb 2014]