Expression of LRRC59 in cancer - Summary - The Human Protein Atlas

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LRRC59

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TISSUE

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CELL

PATHOLOGY

PATHOLOGY ATLAS

GENE/PROTEIN

Antibody validation

Dictionary


Level of antibody staining/expression
	High Medium Low Not detected

GENERAL INFORMATION
Gene name	LRRC59
Gene description	Leucine rich repeat containing 59
Protein class	Predicted intracellular proteins Predicted membrane proteins
Predicted localization	Intracellular,Membrane
Number of transcripts	3
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HUMAN PROTEIN ATLAS INFORMATION

RNA category

TCGA (cancer tissue):	Expressed in all
HPA (cell line):	Expressed in all
HPA (normal tissue):	Expressed in all

Protein evidence

Evidence at protein level

Protein expression
normal tissue

Cytoplasmic expression of varying intensity in most tissues.

ANTIBODY IHC RELIABILITY
Data reliability description	Antibody staining mainly consistent with RNA expression data.
Reliability score	Supported based on 2 antibodies. HPA030827 , HPA030829
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PROGNOSTIC SUMMARY
Prognostic marker in renal cancer (unfavourable), liver cancer (unfavourable), head and neck cancer (unfavourable), urothelial cancer (unfavourable), colorectal cancer (favourable) and pancreatic cancer (unfavourable).
Renal cancer p<0.001 Liver cancer p<0.001 Head and neck cancer p<0.001 Urothelial cancer p<0.001 Colorectal cancer p<0.001 Pancreatic cancer p<0.001 Show all

RNA EXPRESSION OVERVIEW
TCGA dataset RNA cancer category: Expressed in all

PROTEIN EXPRESSION

Colorectal cancer

Prostate cancer

STAINING SUMMARY

HPA030827	HPA030829

GENE INFORMATION
Gene name	LRRC59 (HGNC Symbol)
Synonyms	FLJ21675, PRO1855
Description	Leucine rich repeat containing 59 (HGNC Symbol)
Entrez gene summary
Chromosome	17
Cytoband	q21.33
Chromosome location (bp)	50375059 - 50397553
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000108829 (version 83.38)
Entrez gene	55379
UniProt	Q96AG4 (UniProt - Evidence at protein level)
neXtProt	NX_Q96AG4
Antibodypedia	LRRC59 antibodies

PROTEIN BROWSER

LRRC59-001	LRRC59-002	LRRC59-003

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
LRRC59-001 ENSP00000225972 ENST00000225972	Q96AG4 [Direct mapping] Leucine-rich repeat-containing protein 59 Show all	Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 1TM proteins predicted by MDM Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0005515 [protein binding] GO:0005635 [nuclear envelope] GO:0005783 [endoplasmic reticulum] GO:0005789 [endoplasmic reticulum membrane] GO:0016020 [membrane] GO:0016021 [integral component of membrane] GO:0042645 [mitochondrial nucleoid] GO:0044822 [poly(A) RNA binding] Show all	307 aa 34.9 kDa	No	1
LRRC59-002 ENSP00000459305 ENST00000576448	I3L223 [Direct mapping] Leucine-rich repeat-containing protein 59 Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all		62 aa 6.7 kDa	No	0
LRRC59-003 ENSP00000459616 ENST00000503118	I3L2E8 [Direct mapping] Leucine-rich repeat-containing protein 59 Show all	SPOCTOPUS predicted secreted proteins Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all		57 aa 5.8 kDa	No	0

Contact

contact@proteinatlas.org

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.