Expression of ABCC3 in cancer - Summary

GENERAL INFORMATION
Gene name	ABCC3
Gene description	ATP-binding cassette, sub-family C (CFTR/MRP), member 3
Protein class	Cancer-related genes Predicted intracellular proteins Predicted membrane proteins Transporters
Predicted localization	Intracellular,Membrane
Number of transcripts	4
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HUMAN PROTEIN ATLAS INFORMATION

RNA category

TCGA (cancer tissue):	Mixed
HPA (cell line):	Cell line enhanced (A549, CAPAN-2)
HPA (normal tissue):	Mixed

Protein evidence

Evidence at protein level

Protein expression
normal tissue

Membranous and cytoplasmic expression in several tissues including adrenal gland, gastrointestinal tract and gallbladder.

ANTIBODY IHC RELIABILITY
Data reliability description	Antibody staining mainly not consistent with RNA expression data. Caution, Splice and/or transcript discrepancy exists.
Reliability score	Approved based on 2 antibodies. HPA048483 , CAB037136
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PROGNOSTIC SUMMARY
Prognostic marker in renal cancer (unfavourable) and pancreatic cancer (unfavourable).
Renal cancer p<0.001 Pancreatic cancer p<0.001 Show all

RNA EXPRESSION OVERVIEW
TCGA dataset RNA cancer category: Mixed

PROTEIN EXPRESSION

STAINING SUMMARY

HPA048483	CAB037136

GENE INFORMATION
Gene name	ABCC3 (HGNC Symbol)
Synonyms	cMOAT2, EST90757, MLP2, MOAT-D, MRP3
Description	ATP-binding cassette, sub-family C (CFTR/MRP), member 3 (HGNC Symbol)
Entrez gene summary	The protein encoded by this gene is a member of the superfamily of ATP-binding cassette (ABC) transporters. ABC proteins transport various molecules across extra- and intra-cellular membranes. ABC genes are divided into seven distinct subfamilies (ABC1, MDR/TAP, MRP, ALD, OABP, GCN20, White). This protein is a member of the MRP subfamily which is involved in multi-drug resistance. The specific function of this protein has not yet been determined; however, this protein may play a role in the transport of biliary and intestinal excretion of organic anions. Alternatively spliced variants which encode different protein isoforms have been described; however, not all variants have been fully characterized. [provided by RefSeq, Jul 2008]
Chromosome	17
Cytoband	q21.33
Chromosome location (bp)	50634777 - 50692252
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000108846 (version 83.38)
Entrez gene	8714
UniProt	O15438 (UniProt - Evidence at protein level)
neXtProt	NX_O15438
Antibodypedia	ABCC3 antibodies

PROTEIN BROWSER

ABCC3-001	ABCC3-002	ABCC3-006	ABCC3-013

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
ABCC3-001 ENSP00000285238 ENST00000285238	O15438 [Direct mapping] Canalicular multispecific organic anion transporter 2 Show all	Transporters Primary Active Transporters Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based >9TM proteins predicted by MDM Cancer-related genes Candidate cancer biomarkers Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0005215 [transporter activity] GO:0005524 [ATP binding] GO:0005886 [plasma membrane] GO:0005887 [integral component of plasma membrane] GO:0006810 [transport] GO:0008206 [bile acid metabolic process] GO:0008514 [organic anion transmembrane transporter activity] GO:0015721 [bile acid and bile salt transport] GO:0016020 [membrane] GO:0016021 [integral component of membrane] GO:0016887 [ATPase activity] GO:0042626 [ATPase activity, coupled to transmembrane movement of substances] GO:0044281 [small molecule metabolic process] GO:0055085 [transmembrane transport] Show all	1527 aa 169.3 kDa	No	>9
ABCC3-002 ENSP00000395160 ENST00000427699	O15438 [Direct mapping] Canalicular multispecific organic anion transporter 2 Show all	Transporters Primary Active Transporters Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based >9TM proteins predicted by MDM Cancer-related genes Candidate cancer biomarkers Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0005524 [ATP binding] GO:0005886 [plasma membrane] GO:0005887 [integral component of plasma membrane] GO:0006810 [transport] GO:0008206 [bile acid metabolic process] GO:0008514 [organic anion transmembrane transporter activity] GO:0015721 [bile acid and bile salt transport] GO:0016020 [membrane] GO:0016021 [integral component of membrane] GO:0042626 [ATPase activity, coupled to transmembrane movement of substances] GO:0044281 [small molecule metabolic process] GO:0055085 [transmembrane transport] Show all	572 aa 64.6 kDa	No	>9
ABCC3-006 ENSP00000422786 ENST00000515707	D6RAB7 [Direct mapping] Canalicular multispecific organic anion transporter 2 Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all		76 aa 8.2 kDa	No	0
ABCC3-013 ENSP00000421755 ENST00000513745	H0Y8Q6 [Direct mapping] Canalicular multispecific organic anion transporter 2 Show all	Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 2TM proteins predicted by MDM Protein evidence (Ezkurdia et al 2014) Show all	GO:0005524 [ATP binding] GO:0006810 [transport] GO:0016021 [integral component of membrane] GO:0042626 [ATPase activity, coupled to transmembrane movement of substances] GO:0055085 [transmembrane transport] Show all	300 aa 32.8 kDa	No	2