Tissue expression of MPP2 - Summary - The Human Protein Atlas

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MPP2

TISSUE

CELL

PATHOLOGY

TISSUE ATLAS PRIMARY DATA

GENE/PROTEIN

Antibody validation

Dictionary


Tissue proteome

GENERAL INFORMATION
Gene name	MPP2
Gene description	Membrane protein, palmitoylated 2 (MAGUK p55 subfamily member 2)
Protein class	Predicted intracellular proteins
Predicted localization	Intracellular
Number of transcripts	20
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HUMAN PROTEIN ATLAS INFORMATION

RNA tissue category

HPA:	Tissue enhanced (cerebral cortex, epididymis, parathyroid gland)
GTEx:	Mixed
FANTOM5:	Mixed

Protein evidence

Evidence at protein level

Protein expression

Cytoplasmic expression in a few tissues, highest in a subset of neurons in CNS.

DATA RELIABILITY
Data reliability description	Antibody staining mainly consistent with RNA expression data. Pending external verification.
Reliability score	Approved based on 1 antibody. HPA026486
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RNA AND PROTEIN EXPRESSION SUMMARY

RNA expression (TPM)

Protein expression (score)

Brain

Cerebral cortex

Hippocampus

N/A

Caudate

N/A

Cerebellum

N/A

Endocrine tissues

Thyroid gland

Parathyroid gland

Adrenal gland

Bone marrow & immune system

Appendix

Bone marrow

Lymph node

Tonsil

Spleen

Muscle tissues

Heart muscle

Skeletal muscle

Smooth muscle

Lung

Nasopharynx

N/A

Bronchus

N/A

Lung

Liver & gallbladder

Liver

Gallbladder

Pancreas

Pancreas

Gastrointestinal tract

Oral mucosa

N/A

Salivary gland

Esophagus

Stomach

Duodenum

Small intestine

Colon

Rectum

Kidney & urinary bladder

Kidney

Urinary bladder

Male tissues

Testis

Epididymis

Prostate

Seminal vesicle

Female tissues

Breast

Vagina

N/A

Cervix, uterine

Endometrium

Fallopian tube

Ovary

Placenta

Adipose & soft tissue

Adipose tissue

Soft tissue

N/A

Skin

Skin

Cerebral cortex

PROTEIN EXPRESSION OVERVIEW
Organ Expression Alphabetical

RNA EXPRESSION OVERVIEW
HPA dataset Organ Expression Alphabetical RNA tissue category: Tissue enhanced (cerebral cortex, epididymis, parathyroid gland)
GTEx dataset Organ Expression Alphabetical RNA tissue category: Mixed
FANTOM5 dataset Organ Expression Alphabetical RNA tissue category: Mixed

GENE INFORMATION
Gene name	MPP2 (HGNC Symbol)
Synonyms	DKFZp761D0712, DLG2
Description	Membrane protein, palmitoylated 2 (MAGUK p55 subfamily member 2) (HGNC Symbol)
Entrez gene summary	Palmitoylated membrane protein 2 is a member of a family of membrane-associated proteins termed MAGUKs (membrane-associated guanylate kinase homologs). MAGUKs interact with the cytoskeleton and regulate cell proliferation, signaling pathways, and intracellular junctions. Palmitoylated membrane protein 2 contains a conserved sequence, called the SH3 (src homology 3) motif, found in several other proteins that associate with the cytoskeleton and are suspected to play important roles in signal transduction. [provided by RefSeq, Jul 2008]
Chromosome	17
Cytoband	q21.31
Chromosome location (bp)	43875357 - 43909711
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000108852 (version 83.38)
Entrez gene	4355
UniProt	Q14168 (UniProt - Evidence at protein level)
neXtProt	NX_Q14168
Antibodypedia	MPP2 antibodies

PROTEIN BROWSER

MPP2-001	MPP2-002	MPP2-003	MPP2-004	MPP2-005	MPP2-006	MPP2-007	MPP2-008	MPP2-011	MPP2-012	MPP2-013	MPP2-014	MPP2-015	MPP2-016	MPP2-017	MPP2-018	MPP2-201	MPP2-202	MPP2-203	MPP2-204

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
MPP2-001 ENSP00000269095 ENST00000269095	D3DX48 [Direct mapping] MAGUK p55 subfamily member 2; Membrane protein, palmitoylated 2 (MAGUK p55 subfamily member 2), isoform CRA_b Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0005515 [protein binding] Show all	552 aa 61.6 kDa	No	0
MPP2-002 ENSP00000366389 ENST00000377184	A0A0A0MRU0 [Direct mapping] MAGUK p55 subfamily member 2 Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0005515 [protein binding] Show all	569 aa 63.3 kDa	No	0
MPP2-003 ENSP00000428286 ENST00000461854	D3DX49 [Direct mapping] MAGUK p55 subfamily member 2; Membrane protein, palmitoylated 2 (MAGUK p55 subfamily member 2), isoform CRA_a Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0005515 [protein binding] Show all	576 aa 64.6 kDa	No	0
MPP2-004 ENSP00000479767 ENST00000473246	A0A087WVY2 [Direct mapping] MAGUK p55 subfamily member 2 Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0005515 [protein binding] Show all	186 aa 20.1 kDa	No	0
MPP2-005 ENSP00000428182 ENST00000518766	A0A0C4DH75 [Direct mapping] MAGUK p55 subfamily member 2 Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0005515 [protein binding] GO:0030165 [PDZ domain binding] Show all	597 aa 66.8 kDa	No	0
MPP2-006 ENSP00000428468 ENST00000523220	E5RI47 [Direct mapping] MAGUK p55 subfamily member 2 Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0005515 [protein binding] Show all	190 aa 20.6 kDa	No	0
MPP2-007 ENSP00000430540 ENST00000523501	B4DZ84 [Direct mapping] MAGUK p55 subfamily member 2; cDNA FLJ52373, highly similar to MAGUK p55 subfamily member 2 Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0005515 [protein binding] Show all	541 aa 60.5 kDa	No	0
MPP2-008 ENSP00000428136 ENST00000520305	Q14168 [Direct mapping] MAGUK p55 subfamily member 2 Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0004385 [guanylate kinase activity] GO:0005515 [protein binding] GO:0005887 [integral component of plasma membrane] GO:0007165 [signal transduction] GO:0016020 [membrane] GO:0046037 [GMP metabolic process] GO:0046710 [GDP metabolic process] Show all	413 aa 46.5 kDa	No	0
MPP2-011 ENSP00000428218 ENST00000523762	E5RJK0 [Direct mapping] MAGUK p55 subfamily member 2 Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0005515 [protein binding] Show all	140 aa 15.3 kDa	No	0
MPP2-012 ENSP00000428938 ENST00000520241	E5RK44 [Direct mapping] MAGUK p55 subfamily member 2 Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0005515 [protein binding] Show all	144 aa 15.6 kDa	No	0
MPP2-013 ENSP00000430443 ENST00000521178	E5RK50 [Direct mapping] MAGUK p55 subfamily member 2 Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0005515 [protein binding] Show all	126 aa 13.7 kDa	No	0
MPP2-014 ENSP00000430349 ENST00000522172	E5RFN8 [Direct mapping] MAGUK p55 subfamily member 2 Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0005515 [protein binding] Show all	73 aa 7.9 kDa	No	0
MPP2-015 ENSP00000429364 ENST00000518478	E5RIM9 [Direct mapping] MAGUK p55 subfamily member 2 Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all		31 aa 3.1 kDa	No	0
MPP2-016 ENSP00000428354 ENST00000520406	E5RIU3 [Direct mapping] MAGUK p55 subfamily member 2 Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0005515 [protein binding] Show all	151 aa 16.4 kDa	No	0
MPP2-017 ENSP00000430797 ENST00000523934	E5RI32 [Direct mapping] MAGUK p55 subfamily member 2 Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0005515 [protein binding] Show all	148 aa 16 kDa	No	0
MPP2-018 ENSP00000483278 ENST00000524294	A0A087X0C7 [Direct mapping] MAGUK p55 subfamily member 2 Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0005515 [protein binding] Show all	112 aa 12.2 kDa	No	0
MPP2-201 ENSP00000438012 ENST00000536246	B4DZ84 [Direct mapping] MAGUK p55 subfamily member 2; cDNA FLJ52373, highly similar to MAGUK p55 subfamily member 2 Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0005515 [protein binding] Show all	541 aa 60.5 kDa	No	0
MPP2-202 ENSP00000478528 ENST00000612133	D3DX48 [Direct mapping] MAGUK p55 subfamily member 2; Membrane protein, palmitoylated 2 (MAGUK p55 subfamily member 2), isoform CRA_b Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0005515 [protein binding] Show all	552 aa 61.6 kDa	No	0
MPP2-203 ENSP00000480071 ENST00000622681	B4DZ84 [Direct mapping] MAGUK p55 subfamily member 2; cDNA FLJ52373, highly similar to MAGUK p55 subfamily member 2 Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0005515 [protein binding] Show all	541 aa 60.5 kDa	No	0
MPP2-204 ENSP00000486553 ENST00000625880	A0A0D9SFF8 [Direct mapping] MAGUK p55 subfamily member 2 Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0005515 [protein binding] Show all	573 aa 64 kDa	No	0

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The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.