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Weak to moderate cytoplasmic positivity was observed in several cases of most cancers. Gliomas, liver, ovarian, cervical and endometrial cancers were mainly negative.
GENE INFORMATION
Gene name
SMURF2
Synonyms
Description
SMAD specific E3 ubiquitin protein ligase 2 (HGNC Symbol)
MEMSAT-SVM predicted membrane proteins SPOCTOPUS predicted membrane proteins Predicted intracellular proteins Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014)
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GO:0000122 [negative regulation of transcription from RNA polymerase II promoter] GO:0000151 [ubiquitin ligase complex] GO:0004842 [ubiquitin-protein transferase activity] GO:0005160 [transforming growth factor beta receptor binding] GO:0005515 [protein binding] GO:0005634 [nucleus] GO:0005654 [nucleoplasm] GO:0005829 [cytosol] GO:0005886 [plasma membrane] GO:0006351 [transcription, DNA-templated] GO:0006367 [transcription initiation from RNA polymerase II promoter] GO:0006511 [ubiquitin-dependent protein catabolic process] GO:0007179 [transforming growth factor beta receptor signaling pathway] GO:0010467 [gene expression] GO:0016874 [ligase activity] GO:0017015 [regulation of transforming growth factor beta receptor signaling pathway] GO:0030509 [BMP signaling pathway] GO:0030512 [negative regulation of transforming growth factor beta receptor signaling pathway] GO:0030514 [negative regulation of BMP signaling pathway] GO:0030579 [ubiquitin-dependent SMAD protein catabolic process] GO:0042787 [protein ubiquitination involved in ubiquitin-dependent protein catabolic process] GO:0042802 [identical protein binding] GO:0045121 [membrane raft] GO:0045892 [negative regulation of transcription, DNA-templated] GO:0046332 [SMAD binding] GO:0061630 [ubiquitin protein ligase activity] GO:0090263 [positive regulation of canonical Wnt signaling pathway] GO:1901165 [positive regulation of trophoblast cell migration]