Cell atlas - DUSP3 - The Human Protein Atlas

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DUSP3

TISSUE

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CELL

PATHOLOGY

CELL ATLAS RNA EXPRESSION HUMAN CELLS

GENE/PROTEIN

Antibody validation

Dictionary
	Cytosol
	Nucleoplasm

Human cell
	Cytosol
	Nucleoplasm

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GENERAL INFORMATION
Gene name	DUSP3
Gene description	Dual specificity phosphatase 3
Protein class	Enzymes Plasma proteins Predicted intracellular proteins
Predicted localization	Intracellular
Number of transcripts	3
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HUMAN PROTEIN ATLAS INFORMATION
Summary	Mainly localized to the nucleoplasm. In addition localized to the cytosol.
RNA cell category	Mixed
Protein evidence	Evidence at protein level
Main location	Localized to the Nucleoplasm (supported)
Additional location	In addition localized to the Cytosol (approved)

DATA RELIABILITY
Reliability score	Supported based on 1 antibody. HPA063616
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ASSAYS

RNA EXPRESSION OVERVIEW
RNA cell line category: Mixed Organ Origin Category Expression Alphabetical Cell lines sorted after organ of phenotypic resemblance. Cell lines sorted after biological source for establishment. Cell lines sorted after the cell line category according to Cellosaurus. Cell lines sorted on descending RNA expression. Cell lines sorted alphabetically.

HUMAN CELLS

Summary

Mainly localized to the nucleoplasm. In addition localized to the cytosol.

Main location

Nucleoplasm (supported)

Additional location

Cytosol (approved)


	Toggle channels	Low High G1 S G2 M N/A

Thumbnail	Antibody	Cell line	Location	Single-cell variation	Cell cycle dependent variation
	HPA063616	A549	Nucleoplasm
	HPA063616	A549	Cytosol
	HPA063616	PC-3	Nucleoplasm
	HPA063616	PC-3	Cytosol

GENE INFORMATION
Gene name	DUSP3 (HGNC Symbol)
Synonyms	VHR
Description	Dual specificity phosphatase 3 (HGNC Symbol)
Entrez gene summary	The protein encoded by this gene is a member of the dual specificity protein phosphatase subfamily. These phosphatases inactivate their target kinases by dephosphorylating both the phosphoserine/threonine and phosphotyrosine residues. They negatively regulate members of the mitogen-activated protein (MAP) kinase superfamily (MAPK/ERK, SAPK/JNK, p38), which are associated with cellular proliferation and differentiation. Different members of the family of dual specificity phosphatases show distinct substrate specificities for various MAP kinases, different tissue distribution and subcellular localization, and different modes of inducibility of their expression by extracellular stimuli. This gene maps in a region that contains the BRCA1 locus which confers susceptibility to breast and ovarian cancer. Although DUSP3 is expressed in both breast and ovarian tissues, mutation screening in breast cancer pedigrees and in sporadic tumors was negative, leading to the conclusion that this gene is not BRCA1. [provided by RefSeq, Jul 2008]
Chromosome	17
Cytoband	q21.31
Chromosome location (bp)	43766121 - 43778988
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000108861 (version 83.38)
Entrez gene	1845
UniProt	P51452 (UniProt - Evidence at protein level)
neXtProt	NX_P51452
Antibodypedia	DUSP3 antibodies

PROTEIN BROWSER

DUSP3-001	DUSP3-003	DUSP3-004

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
DUSP3-001 ENSP00000226004 ENST00000226004	P51452 [Direct mapping] Dual specificity protein phosphatase 3 Show all	Enzymes ENZYME proteins Hydrolases SPOCTOPUS predicted membrane proteins Predicted intracellular proteins Plasma proteins Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0000188 [inactivation of MAPK activity] GO:0001772 [immunological synapse] GO:0002224 [toll-like receptor signaling pathway] GO:0002755 [MyD88-dependent toll-like receptor signaling pathway] GO:0002756 [MyD88-independent toll-like receptor signaling pathway] GO:0004721 [phosphoprotein phosphatase activity] GO:0004725 [protein tyrosine phosphatase activity] GO:0005634 [nucleus] GO:0005654 [nucleoplasm] GO:0005737 [cytoplasm] GO:0005829 [cytosol] GO:0006470 [protein dephosphorylation] GO:0008138 [protein tyrosine/serine/threonine phosphatase activity] GO:0016311 [dephosphorylation] GO:0016791 [phosphatase activity] GO:0019901 [protein kinase binding] GO:0033549 [MAP kinase phosphatase activity] GO:0034134 [toll-like receptor 2 signaling pathway] GO:0034138 [toll-like receptor 3 signaling pathway] GO:0034142 [toll-like receptor 4 signaling pathway] GO:0034146 [toll-like receptor 5 signaling pathway] GO:0034162 [toll-like receptor 9 signaling pathway] GO:0034166 [toll-like receptor 10 signaling pathway] GO:0035335 [peptidyl-tyrosine dephosphorylation] GO:0035666 [TRIF-dependent toll-like receptor signaling pathway] GO:0038123 [toll-like receptor TLR1:TLR2 signaling pathway] GO:0038124 [toll-like receptor TLR6:TLR2 signaling pathway] GO:0043409 [negative regulation of MAPK cascade] GO:0045087 [innate immune response] GO:0045931 [positive regulation of mitotic cell cycle] GO:0046329 [negative regulation of JNK cascade] GO:0048011 [neurotrophin TRK receptor signaling pathway] GO:0050860 [negative regulation of T cell receptor signaling pathway] GO:0050868 [negative regulation of T cell activation] GO:0051403 [stress-activated MAPK cascade] GO:0070062 [extracellular exosome] GO:0070373 [negative regulation of ERK1 and ERK2 cascade] Show all	185 aa 20.5 kDa	No	0
DUSP3-003 ENSP00000468604 ENST00000590935	K7ES89 [Direct mapping] Dual-specificity protein phosphatase 3 Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0006470 [protein dephosphorylation] GO:0008138 [protein tyrosine/serine/threonine phosphatase activity] Show all	132 aa 14.2 kDa	No	0
DUSP3-004 ENSP00000466069 ENST00000590753	K7ELG5 [Direct mapping] Dual-specificity protein phosphatase 3 Show all	SCAMPI predicted membrane proteins Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0004725 [protein tyrosine phosphatase activity] GO:0006470 [protein dephosphorylation] GO:0008138 [protein tyrosine/serine/threonine phosphatase activity] GO:0016311 [dephosphorylation] GO:0016791 [phosphatase activity] GO:0035335 [peptidyl-tyrosine dephosphorylation] Show all	112 aa 12.5 kDa	No	0

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The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.