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CACNG1

GENERAL INFORMATION

Gene name

 CACNG1

Gene description

 Calcium channel, voltage-dependent, gamma subunit 1

Protein class

 FDA approved drug targets
Predicted membrane proteins
Transporters

Predicted localization

 Membrane

Number of transcripts

 1
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HUMAN PROTEIN ATLAS INFORMATION

RNA category
TCGA (cancer tissue):Tissue enhanced (head and neck cancer)
HPA (cell line):Cell line enhanced (SH-SY5Y)
HPA (normal tissue):Tissue enriched (skeletal muscle)

Protein evidence

 Evidence at protein level

ANTIBODY IHC RELIABILITY

Reliability score

 Pending cancer tissue analysis.

PROGNOSTIC SUMMARY
Gene product is not prognostic.
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RNA EXPRESSION OVERVIEW
TCGA dataset
RNA cancer category: Tissue enhanced (head and neck cancer)

PROTEIN EXPRESSION

Pending cancer tissue analysis

STAINING SUMMARY

 

GENE INFORMATION

Gene name

 CACNG1 (HGNC Symbol)

Synonyms

 CACNLG

Description

 Calcium channel, voltage-dependent, gamma subunit 1 (HGNC Symbol)

Entrez gene summary

 Voltage-dependent calcium channels are composed of five subunits. The protein encoded by this gene represents one of these subunits, gamma, and is one of two known gamma subunit proteins. This particular gamma subunit is part of skeletal muscle 1,4-dihydropyridine-sensitive calcium channels and is an integral membrane protein that plays a role in excitation-contraction coupling. This gene is part of a functionally diverse eight-member protein subfamily of the PMP-22/EMP/MP20 family and is located in a cluster with two family members that function as transmembrane AMPA receptor regulatory proteins (TARPs). [provided by RefSeq, Dec 2010]

Chromosome

 17

Cytoband

 q24.2

Chromosome location (bp)

 67044590 - 67056797

Protein evidence

 Evidence at protein level (all genes)

Ensembl

 ENSG00000108878 (version 83.38)

Entrez gene

 786

UniProt

 Q06432 (UniProt - Evidence at protein level)

neXtProt

 NX_Q06432

Antibodypedia

 CACNG1 antibodies

PROTEIN BROWSER
CACNG1-001

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)
CACNG1-001
ENSP00000226021
ENST00000226021
Q06432 [Direct mapping]
Voltage-dependent calcium channel gamma-1 subunit
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Transporters
   Accessory Factors Involved in Transport
Predicted membrane proteins
   Prediction method-based
   Membrane proteins predicted by MDM
   MEMSAT3 predicted membrane proteins
   MEMSAT-SVM predicted membrane proteins
   Phobius predicted membrane proteins
   SCAMPI predicted membrane proteins
   SPOCTOPUS predicted membrane proteins
   THUMBUP predicted membrane proteins
   TMHMM predicted membrane proteins
   # TM segments-based
   3TM proteins predicted by MDM
FDA approved drug targets
   Small molecule drugs
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GO:0005245 [voltage-gated calcium channel activity]
GO:0005515 [protein binding]
GO:0005622 [intracellular]
GO:0005891 [voltage-gated calcium channel complex]
GO:0006810 [transport]
GO:0006936 [muscle contraction]
GO:0016021 [integral component of membrane]
GO:0034765 [regulation of ion transmembrane transport]
GO:0070296 [sarcoplasmic reticulum calcium ion transport]
GO:0070588 [calcium ion transmembrane transport]
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 222 aa
25 kDa 		Yes 3

Contact

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.