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HLF

GENERAL INFORMATION

Gene name

 HLF

Gene description

 Hepatic leukemia factor

Protein class

 Cancer-related genes
Disease related genes
Predicted intracellular proteins
Transcription factors

Predicted localization

 Intracellular

Number of transcripts

 5
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HUMAN PROTEIN ATLAS INFORMATION

RNA category
TCGA (cancer tissue):Tissue enhanced (liver cancer)
HPA (cell line):Group enriched (HDLM-2, Hep G2)
HPA (normal tissue):Mixed

Protein evidence

 Evidence at protein level

ANTIBODY IHC RELIABILITY

Reliability score

 Pending cancer tissue analysis.

PROGNOSTIC SUMMARY
Prognostic marker in lung cancer (favourable), renal cancer (favourable) and head and neck cancer (favourable).
Lung cancer p<0.001
Renal cancer p<0.001
Head and neck cancer p<0.001
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RNA EXPRESSION OVERVIEW
TCGA dataset
RNA cancer category: Tissue enhanced (liver cancer)

PROTEIN EXPRESSION

Pending cancer tissue analysis

STAINING SUMMARY

 

GENE INFORMATION

Gene name

 HLF (HGNC Symbol)

Synonyms

 MGC33822

Description

 Hepatic leukemia factor (HGNC Symbol)

Entrez gene summary

 This gene encodes a member of the proline and acidic-rich (PAR) protein family, a subset of the bZIP transcription factors. The encoded protein forms homodimers or heterodimers with other PAR family members and binds sequence-specific promoter elements to activate transcription. Chromosomal translocations fusing portions of this gene with the E2A gene cause a subset of childhood B-lineage acute lymphoid leukemias. Alternatively spliced transcript variants have been described, but their biological validity has not been determined. [provided by RefSeq, Jul 2008]

Chromosome

 17

Cytoband

 q22

Chromosome location (bp)

 55265012 - 55325065

Protein evidence

 Evidence at protein level (all genes)

Ensembl

 ENSG00000108924 (version 83.38)

Entrez gene

 3131

UniProt

 Q16534 (UniProt - Evidence at transcript level)

neXtProt

 NX_Q16534

Antibodypedia

 HLF antibodies

PROTEIN BROWSER
HLF-001
HLF-002
HLF-003
HLF-005
HLF-011

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)
HLF-001
ENSP00000226067
ENST00000226067
Q16534 [Direct mapping]
Hepatic leukemia factor
Show all
Predicted intracellular proteins
Transcription factors
   Basic domains
Cancer-related genes
   COSMIC somatic mutations in cancer genes
   COSMIC Somatic Mutations
   COSMIC Translocations
Disease related genes
Show all
GO:0003677 [DNA binding]
GO:0003690 [double-stranded DNA binding]
GO:0003700 [transcription factor activity, sequence-specific DNA binding]
GO:0005634 [nucleus]
GO:0006355 [regulation of transcription, DNA-templated]
GO:0006366 [transcription from RNA polymerase II promoter]
GO:0007275 [multicellular organismal development]
GO:0035914 [skeletal muscle cell differentiation]
GO:0043565 [sequence-specific DNA binding]
GO:0048511 [rhythmic process]
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 295 aa
33.2 kDa 		No 0
HLF-002
ENSP00000402496
ENST00000430986
Q16534 [Direct mapping]
Hepatic leukemia factor
Show all
Predicted intracellular proteins
Transcription factors
   Basic domains
Cancer-related genes
   COSMIC somatic mutations in cancer genes
   COSMIC Somatic Mutations
   COSMIC Translocations
Disease related genes
Show all
GO:0003677 [DNA binding]
GO:0003690 [double-stranded DNA binding]
GO:0003700 [transcription factor activity, sequence-specific DNA binding]
GO:0005634 [nucleus]
GO:0006355 [regulation of transcription, DNA-templated]
GO:0006366 [transcription from RNA polymerase II promoter]
GO:0007275 [multicellular organismal development]
GO:0043565 [sequence-specific DNA binding]
GO:0048511 [rhythmic process]
Show all
 210 aa
23.5 kDa 		No 0
HLF-003
ENSP00000460296
ENST00000573945
Q16534 [Direct mapping]
Hepatic leukemia factor
Show all
Predicted intracellular proteins
Transcription factors
   Basic domains
Cancer-related genes
   COSMIC somatic mutations in cancer genes
   COSMIC Somatic Mutations
   COSMIC Translocations
Disease related genes
Show all
GO:0003677 [DNA binding]
GO:0003690 [double-stranded DNA binding]
GO:0003700 [transcription factor activity, sequence-specific DNA binding]
GO:0005634 [nucleus]
GO:0006355 [regulation of transcription, DNA-templated]
GO:0006366 [transcription from RNA polymerase II promoter]
GO:0007275 [multicellular organismal development]
GO:0043565 [sequence-specific DNA binding]
GO:0048511 [rhythmic process]
Show all
 210 aa
23.5 kDa 		No 0
HLF-005
ENSP00000460572
ENST00000575345
Q16534 [Direct mapping]
Hepatic leukemia factor
Show all
Predicted intracellular proteins
Transcription factors
   Basic domains
Cancer-related genes
   COSMIC somatic mutations in cancer genes
   COSMIC Somatic Mutations
   COSMIC Translocations
Disease related genes
Show all
GO:0003677 [DNA binding]
GO:0003690 [double-stranded DNA binding]
GO:0003700 [transcription factor activity, sequence-specific DNA binding]
GO:0005634 [nucleus]
GO:0006355 [regulation of transcription, DNA-templated]
GO:0006366 [transcription from RNA polymerase II promoter]
GO:0007275 [multicellular organismal development]
GO:0043565 [sequence-specific DNA binding]
GO:0048511 [rhythmic process]
Show all
 210 aa
23.5 kDa 		No 0
HLF-011
ENSP00000461455
ENST00000572002
I3L4R4 [Direct mapping]
Hepatic leukemia factor
Show all
Predicted intracellular proteins
Cancer-related genes
   COSMIC somatic mutations in cancer genes
   COSMIC Somatic Mutations
   COSMIC Translocations
Show all
GO:0003700 [transcription factor activity, sequence-specific DNA binding]
GO:0006355 [regulation of transcription, DNA-templated]
GO:0043565 [sequence-specific DNA binding]
Show all
 236 aa
26.5 kDa 		No 0

Contact

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.