Expression of SLC16A6 in cancer - Summary - The Human Protein Atlas

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SLC16A6

TISSUE

CELL

PATHOLOGY

PATHOLOGY ATLAS

GENE/PROTEIN

Antibody validation

Dictionary


Level of antibody staining/expression
	High Medium Low Not detected

GENERAL INFORMATION
Gene name	SLC16A6
Gene description	Solute carrier family 16, member 6
Protein class	Plasma proteins Predicted membrane proteins Transporters
Predicted localization	Membrane
Number of transcripts	5
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HUMAN PROTEIN ATLAS INFORMATION

RNA category

TCGA (cancer tissue):	Group enriched (breast cancer, melanoma)
HPA (cell line):	Cell line enriched (SK-MEL-30)
HPA (normal tissue):	Tissue enhanced (epididymis)

Protein evidence

Evidence at protein level

Protein expression
normal tissue

Membranous expression in a few tissues.

ANTIBODY IHC RELIABILITY
Data reliability description	Antibody staining not consistent with RNA expression data. Presumed off target binding observed and disregarded. External characterization data supports antibody staining.
Reliability score	Uncertain based on 1 antibody. HPA054459
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PROGNOSTIC SUMMARY
Gene product is not prognostic.
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RNA EXPRESSION OVERVIEW
TCGA dataset RNA cancer category: Group enriched (breast cancer, melanoma)

PROTEIN EXPRESSION

Colorectal cancer

Prostate cancer

STAINING SUMMARY

HPA054459

GENE INFORMATION
Gene name	SLC16A6 (HGNC Symbol)
Synonyms	MCT6, MCT7
Description	Solute carrier family 16, member 6 (HGNC Symbol)
Entrez gene summary
Chromosome	17
Cytoband	q24.2
Chromosome location (bp)	68267026 - 68291267
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000108932 (version 83.38)
Entrez gene	9120
UniProt	O15403 (UniProt - Evidence at protein level)
neXtProt	NX_O15403
Antibodypedia	SLC16A6 antibodies

PROTEIN BROWSER

SLC16A6-001	SLC16A6-002	SLC16A6-003	SLC16A6-004	SLC16A6-201

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
SLC16A6-001 ENSP00000462985 ENST00000580666	O15403 [Direct mapping] Monocarboxylate transporter 7 A0A024R8J3 [Target identity:100%; Query identity:100%] Solute carrier family 16 (Monocarboxylic acid transporters), member 6, isoform CRA_a Show all	Transporters Electrochemical Potential-driven transporters Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based >9TM proteins predicted by MDM Plasma proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0005887 [integral component of plasma membrane] GO:0008028 [monocarboxylic acid transmembrane transporter activity] GO:0015293 [symporter activity] GO:0015718 [monocarboxylic acid transport] GO:0016020 [membrane] GO:0016021 [integral component of membrane] GO:0034220 [ion transmembrane transport] GO:0055085 [transmembrane transport] Show all	523 aa 57.4 kDa	No	>9
SLC16A6-002 ENSP00000319991 ENST00000327268	O15403 [Direct mapping] Monocarboxylate transporter 7 A0A024R8J3 [Target identity:100%; Query identity:100%] Solute carrier family 16 (Monocarboxylic acid transporters), member 6, isoform CRA_a Show all	Transporters Electrochemical Potential-driven transporters Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based >9TM proteins predicted by MDM Plasma proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0005887 [integral component of plasma membrane] GO:0008028 [monocarboxylic acid transmembrane transporter activity] GO:0015293 [symporter activity] GO:0015718 [monocarboxylic acid transport] GO:0016020 [membrane] GO:0016021 [integral component of membrane] GO:0034220 [ion transmembrane transport] GO:0055085 [transmembrane transport] Show all	523 aa 57.4 kDa	No	>9
SLC16A6-003 ENSP00000462239 ENST00000582867	J3KS02 [Direct mapping] Monocarboxylate transporter 7 Show all	Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 2TM proteins predicted by MDM Protein evidence (Ezkurdia et al 2014) Show all	GO:0016021 [integral component of membrane] GO:0034220 [ion transmembrane transport] Show all	85 aa 9.5 kDa	No	2
SLC16A6-004 ENSP00000463070 ENST00000583477	J3KTN2 [Direct mapping] Monocarboxylate transporter 7 Show all	Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 3TM proteins predicted by MDM Protein evidence (Ezkurdia et al 2014) Show all	GO:0016021 [integral component of membrane] GO:0034220 [ion transmembrane transport] Show all	129 aa 14.4 kDa	No	3
SLC16A6-201 ENSP00000480820 ENST00000620436	A0A087WX92 [Direct mapping] Monocarboxylate transporter 7 Show all	Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based >9TM proteins predicted by MDM Protein evidence (Ezkurdia et al 2014) Show all	GO:0016021 [integral component of membrane] GO:0034220 [ion transmembrane transport] GO:0055085 [transmembrane transport] Show all	522 aa 57.5 kDa	No	>9

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The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.