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MAP2K6

GENERAL INFORMATION

Gene name

 MAP2K6

Gene description

 Mitogen-activated protein kinase kinase 6

Protein class

 Enzymes
Predicted intracellular proteins

Predicted localization

 Intracellular

Number of transcripts

 5
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HUMAN PROTEIN ATLAS INFORMATION

RNA category
TCGA (cancer tissue):Mixed
HPA (cell line):Cell line enhanced (A549)
HPA (normal tissue):Mixed

Protein evidence

 Evidence at protein level

Protein expression
normal tissue

 Cytoplasmic expression in most tissues, highly abundant in glandular cells of the gastrointestinal tract, breast and endometrium.

ANTIBODY IHC RELIABILITY

Data reliability
description

 Antibody staining mainly consistent with RNA expression data.

Reliability score

 Approved based on 2 antibodies.
HPA031134 , CAB007744
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PROGNOSTIC SUMMARY
Prognostic marker in breast cancer (favourable) and pancreatic cancer (favourable).
Breast cancer p<0.001
Pancreatic cancer p<0.001
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RNA EXPRESSION OVERVIEW
TCGA dataset
RNA cancer category: Mixed

PROTEIN EXPRESSION
Colorectal cancer
Breast cancer
Prostate cancer
Lung cancer
Endometrial cancer

STAINING SUMMARY
HPA031134
CAB007744

GENE INFORMATION

Gene name

 MAP2K6 (HGNC Symbol)

Synonyms

 MAPKK6, MEK6, MKK6, PRKMK6, SAPKK3

Description

 Mitogen-activated protein kinase kinase 6 (HGNC Symbol)

Entrez gene summary

 This gene encodes a member of the dual specificity protein kinase family, which functions as a mitogen-activated protein (MAP) kinase kinase. MAP kinases, also known as extracellular signal-regulated kinases (ERKs), act as an integration point for multiple biochemical signals. This protein phosphorylates and activates p38 MAP kinase in response to inflammatory cytokines or environmental stress. As an essential component of p38 MAP kinase mediated signal transduction pathway, this gene is involved in many cellular processes such as stress induced cell cycle arrest, transcription activation and apoptosis. [provided by RefSeq, Jul 2008]

Chromosome

 17

Cytoband

 q24.3

Chromosome location (bp)

 69414698 - 69543331

Protein evidence

 Evidence at protein level (all genes)

Ensembl

 ENSG00000108984 (version 83.38)

Entrez gene

 5608

UniProt

 P52564 (UniProt - Evidence at protein level)

neXtProt

 NX_P52564

Antibodypedia

 MAP2K6 antibodies

PROTEIN BROWSER
MAP2K6-001
MAP2K6-004
MAP2K6-006
MAP2K6-008
MAP2K6-201

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)
MAP2K6-001
ENSP00000468348
ENST00000590474
P52564 [Direct mapping]
Dual specificity mitogen-activated protein kinase kinase 6
A8K3Y2 [Target identity:100%; Query identity:100%]
Mitogen-activated protein kinase kinase 6; Mitogen-activated protein kinase kinase 6, isoform CRA_b; cDNA FLJ75671, highly similar to Homo sapiens mitogen-activated protein kinase kinase 6 (MAP2K6), transcript variant 1, mRNA
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Enzymes
   ENZYME proteins
   Transferases
   Kinases
   STE Ser/Thr protein kinases
Predicted intracellular proteins
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000165 [MAPK cascade]
GO:0000187 [activation of MAPK activity]
GO:0001934 [positive regulation of protein phosphorylation]
GO:0002224 [toll-like receptor signaling pathway]
GO:0002755 [MyD88-dependent toll-like receptor signaling pathway]
GO:0002756 [MyD88-independent toll-like receptor signaling pathway]
GO:0002931 [response to ischemia]
GO:0004672 [protein kinase activity]
GO:0004674 [protein serine/threonine kinase activity]
GO:0004708 [MAP kinase kinase activity]
GO:0004713 [protein tyrosine kinase activity]
GO:0005515 [protein binding]
GO:0005524 [ATP binding]
GO:0005654 [nucleoplasm]
GO:0005737 [cytoplasm]
GO:0005829 [cytosol]
GO:0005856 [cytoskeleton]
GO:0006351 [transcription, DNA-templated]
GO:0006355 [regulation of transcription, DNA-templated]
GO:0006468 [protein phosphorylation]
GO:0006915 [apoptotic process]
GO:0006975 [DNA damage induced protein phosphorylation]
GO:0007050 [cell cycle arrest]
GO:0007165 [signal transduction]
GO:0007346 [regulation of mitotic cell cycle]
GO:0018108 [peptidyl-tyrosine phosphorylation]
GO:0019901 [protein kinase binding]
GO:0022602 [ovulation cycle process]
GO:0023014 [signal transduction by protein phosphorylation]
GO:0031098 [stress-activated protein kinase signaling cascade]
GO:0032308 [positive regulation of prostaglandin secretion]
GO:0034134 [toll-like receptor 2 signaling pathway]
GO:0034138 [toll-like receptor 3 signaling pathway]
GO:0034142 [toll-like receptor 4 signaling pathway]
GO:0034146 [toll-like receptor 5 signaling pathway]
GO:0034162 [toll-like receptor 9 signaling pathway]
GO:0034166 [toll-like receptor 10 signaling pathway]
GO:0035666 [TRIF-dependent toll-like receptor signaling pathway]
GO:0035872 [nucleotide-binding domain, leucine rich repeat containing receptor signaling pathway]
GO:0038123 [toll-like receptor TLR1:TLR2 signaling pathway]
GO:0038124 [toll-like receptor TLR6:TLR2 signaling pathway]
GO:0042493 [response to drug]
GO:0042692 [muscle cell differentiation]
GO:0042981 [regulation of apoptotic process]
GO:0043065 [positive regulation of apoptotic process]
GO:0045087 [innate immune response]
GO:0051149 [positive regulation of muscle cell differentiation]
GO:0051403 [stress-activated MAPK cascade]
GO:0051770 [positive regulation of nitric-oxide synthase biosynthetic process]
GO:0060048 [cardiac muscle contraction]
GO:0070423 [nucleotide-binding oligomerization domain containing signaling pathway]
GO:0072709 [cellular response to sorbitol]
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 334 aa
37.5 kDa 		No 0
MAP2K6-004
ENSP00000467213
ENST00000589647
P52564 [Direct mapping]
Dual specificity mitogen-activated protein kinase kinase 6
A0A024R8K3 [Target identity:100%; Query identity:100%]
Mitogen-activated protein kinase kinase 6, isoform CRA_a
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Enzymes
   ENZYME proteins
   Transferases
   Kinases
   STE Ser/Thr protein kinases
   MEMSAT-SVM predicted membrane proteins
   SPOCTOPUS predicted membrane proteins
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000187 [activation of MAPK activity]
GO:0002224 [toll-like receptor signaling pathway]
GO:0002755 [MyD88-dependent toll-like receptor signaling pathway]
GO:0002756 [MyD88-independent toll-like receptor signaling pathway]
GO:0004672 [protein kinase activity]
GO:0004674 [protein serine/threonine kinase activity]
GO:0004713 [protein tyrosine kinase activity]
GO:0005515 [protein binding]
GO:0005524 [ATP binding]
GO:0005654 [nucleoplasm]
GO:0005737 [cytoplasm]
GO:0005829 [cytosol]
GO:0005856 [cytoskeleton]
GO:0006351 [transcription, DNA-templated]
GO:0006355 [regulation of transcription, DNA-templated]
GO:0006468 [protein phosphorylation]
GO:0006975 [DNA damage induced protein phosphorylation]
GO:0007050 [cell cycle arrest]
GO:0007165 [signal transduction]
GO:0007346 [regulation of mitotic cell cycle]
GO:0018108 [peptidyl-tyrosine phosphorylation]
GO:0019901 [protein kinase binding]
GO:0023014 [signal transduction by protein phosphorylation]
GO:0031098 [stress-activated protein kinase signaling cascade]
GO:0034134 [toll-like receptor 2 signaling pathway]
GO:0034138 [toll-like receptor 3 signaling pathway]
GO:0034142 [toll-like receptor 4 signaling pathway]
GO:0034146 [toll-like receptor 5 signaling pathway]
GO:0034162 [toll-like receptor 9 signaling pathway]
GO:0034166 [toll-like receptor 10 signaling pathway]
GO:0035666 [TRIF-dependent toll-like receptor signaling pathway]
GO:0035872 [nucleotide-binding domain, leucine rich repeat containing receptor signaling pathway]
GO:0038123 [toll-like receptor TLR1:TLR2 signaling pathway]
GO:0038124 [toll-like receptor TLR6:TLR2 signaling pathway]
GO:0042692 [muscle cell differentiation]
GO:0042981 [regulation of apoptotic process]
GO:0045087 [innate immune response]
GO:0051149 [positive regulation of muscle cell differentiation]
GO:0051403 [stress-activated MAPK cascade]
GO:0070423 [nucleotide-binding oligomerization domain containing signaling pathway]
Show all
 278 aa
31.3 kDa 		No 0
MAP2K6-006
ENSP00000466143
ENST00000589295
K7ELM6 [Direct mapping]
Dual-specificity mitogen-activated protein kinase kinase 6
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Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000187 [activation of MAPK activity]
GO:0004672 [protein kinase activity]
GO:0004674 [protein serine/threonine kinase activity]
GO:0005524 [ATP binding]
GO:0005737 [cytoplasm]
GO:0006468 [protein phosphorylation]
GO:0007346 [regulation of mitotic cell cycle]
GO:0023014 [signal transduction by protein phosphorylation]
GO:0031098 [stress-activated protein kinase signaling cascade]
GO:0042981 [regulation of apoptotic process]
Show all
 84 aa
9.7 kDa 		No 0
MAP2K6-008
ENSP00000464916
ENST00000588110
K7EIW3 [Direct mapping]
Dual-specificity mitogen-activated protein kinase kinase 6
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Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000187 [activation of MAPK activity]
GO:0004672 [protein kinase activity]
GO:0004674 [protein serine/threonine kinase activity]
GO:0005524 [ATP binding]
GO:0005737 [cytoplasm]
GO:0006468 [protein phosphorylation]
GO:0007346 [regulation of mitotic cell cycle]
GO:0023014 [signal transduction by protein phosphorylation]
GO:0031098 [stress-activated protein kinase signaling cascade]
GO:0042981 [regulation of apoptotic process]
Show all
 128 aa
14.4 kDa 		No 0
MAP2K6-201
ENSP00000477701
ENST00000613873
P52564 [Direct mapping]
Dual specificity mitogen-activated protein kinase kinase 6
A0A024R8K3 [Target identity:100%; Query identity:100%]
Mitogen-activated protein kinase kinase 6, isoform CRA_a
Show all
Enzymes
   ENZYME proteins
   Transferases
   Kinases
   STE Ser/Thr protein kinases
   MEMSAT-SVM predicted membrane proteins
   SPOCTOPUS predicted membrane proteins
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000187 [activation of MAPK activity]
GO:0002224 [toll-like receptor signaling pathway]
GO:0002755 [MyD88-dependent toll-like receptor signaling pathway]
GO:0002756 [MyD88-independent toll-like receptor signaling pathway]
GO:0004672 [protein kinase activity]
GO:0004674 [protein serine/threonine kinase activity]
GO:0004713 [protein tyrosine kinase activity]
GO:0005515 [protein binding]
GO:0005524 [ATP binding]
GO:0005654 [nucleoplasm]
GO:0005737 [cytoplasm]
GO:0005829 [cytosol]
GO:0005856 [cytoskeleton]
GO:0006351 [transcription, DNA-templated]
GO:0006355 [regulation of transcription, DNA-templated]
GO:0006468 [protein phosphorylation]
GO:0006975 [DNA damage induced protein phosphorylation]
GO:0007050 [cell cycle arrest]
GO:0007165 [signal transduction]
GO:0007346 [regulation of mitotic cell cycle]
GO:0018108 [peptidyl-tyrosine phosphorylation]
GO:0019901 [protein kinase binding]
GO:0023014 [signal transduction by protein phosphorylation]
GO:0031098 [stress-activated protein kinase signaling cascade]
GO:0034134 [toll-like receptor 2 signaling pathway]
GO:0034138 [toll-like receptor 3 signaling pathway]
GO:0034142 [toll-like receptor 4 signaling pathway]
GO:0034146 [toll-like receptor 5 signaling pathway]
GO:0034162 [toll-like receptor 9 signaling pathway]
GO:0034166 [toll-like receptor 10 signaling pathway]
GO:0035666 [TRIF-dependent toll-like receptor signaling pathway]
GO:0035872 [nucleotide-binding domain, leucine rich repeat containing receptor signaling pathway]
GO:0038123 [toll-like receptor TLR1:TLR2 signaling pathway]
GO:0038124 [toll-like receptor TLR6:TLR2 signaling pathway]
GO:0042692 [muscle cell differentiation]
GO:0042981 [regulation of apoptotic process]
GO:0045087 [innate immune response]
GO:0051149 [positive regulation of muscle cell differentiation]
GO:0051403 [stress-activated MAPK cascade]
GO:0070423 [nucleotide-binding oligomerization domain containing signaling pathway]
Show all
 278 aa
31.3 kDa 		No 0

Contact

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.