Expression of DHRS7B in cancer - Summary - The Human Protein Atlas

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DHRS7B

TISSUE

CELL

PATHOLOGY

PATHOLOGY ATLAS

GENE/PROTEIN

Antibody validation

Dictionary


Level of antibody staining/expression
	High Medium Low Not detected

GENERAL INFORMATION
Gene name	DHRS7B
Gene description	Dehydrogenase/reductase (SDR family) member 7B
Protein class	Predicted intracellular proteins Predicted membrane proteins
Predicted localization	Intracellular,Membrane
Number of transcripts	5
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HUMAN PROTEIN ATLAS INFORMATION

RNA category

TCGA (cancer tissue):	Expressed in all
HPA (cell line):	Expressed in all
HPA (normal tissue):	Expressed in all

Protein evidence

Evidence at protein level

Protein expression
normal tissue

Cytoplasmic expression at variable levels in several different cell types.

ANTIBODY IHC RELIABILITY
Data reliability description	Pending external verification.
Reliability score	Uncertain based on 2 antibodies. HPA012132 , HPA016873
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PROGNOSTIC SUMMARY
Prognostic marker in endometrial cancer (favourable) and renal cancer (favourable).
Endometrial cancer p<0.001 Renal cancer p<0.001 Show all

RNA EXPRESSION OVERVIEW
TCGA dataset RNA cancer category: Expressed in all

PROTEIN EXPRESSION

Colorectal cancer

Prostate cancer

Endometrial cancer

STAINING SUMMARY

HPA012132	HPA016873

GENE INFORMATION
Gene name	DHRS7B (HGNC Symbol)
Synonyms	CGI-93, DKFZp566O084, MGC8916, SDR32C1
Description	Dehydrogenase/reductase (SDR family) member 7B (HGNC Symbol)
Entrez gene summary	This gene is located within the Smith-Magenis syndrome region on chromosome 17. It encodes a protein of unknown function. [provided by RefSeq, Jul 2008]
Chromosome	17
Cytoband	p11.2
Chromosome location (bp)	21123364 - 21193265
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000109016 (version 83.38)
Entrez gene	25979
UniProt	Q6IAN0 (UniProt - Evidence at protein level)
neXtProt	NX_Q6IAN0
Antibodypedia	DHRS7B antibodies

PROTEIN BROWSER

DHRS7B-001	DHRS7B-002	DHRS7B-009	DHRS7B-010	DHRS7B-011

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
DHRS7B-001 ENSP00000378887 ENST00000395511	Q6IAN0 [Direct mapping] Dehydrogenase/reductase SDR family member 7B Show all	Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 2TM proteins predicted by MDM Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0003674 [molecular_function] GO:0005789 [endoplasmic reticulum membrane] GO:0008150 [biological_process] GO:0008152 [metabolic process] GO:0016020 [membrane] GO:0016021 [integral component of membrane] GO:0016491 [oxidoreductase activity] GO:0055114 [oxidation-reduction process] Show all	325 aa 35.1 kDa	No	2
DHRS7B-002 ENSP00000468585 ENST00000579303	A0A0C4DGQ8 [Direct mapping] Dehydrogenase/reductase SDR family member 7B Show all	Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 2TM proteins predicted by MDM Protein evidence (Ezkurdia et al 2014) Show all	GO:0008152 [metabolic process] GO:0016021 [integral component of membrane] GO:0016491 [oxidoreductase activity] GO:0055114 [oxidation-reduction process] Show all	310 aa 33.5 kDa	No	2
DHRS7B-009 ENSP00000463588 ENST00000581463	J3QLJ8 [Direct mapping] Dehydrogenase/reductase SDR family member 7B Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0008152 [metabolic process] GO:0016491 [oxidoreductase activity] GO:0055114 [oxidation-reduction process] Show all	107 aa 11.9 kDa	No	0
DHRS7B-010 ENSP00000462139 ENST00000583388	J3KRS1 [Direct mapping] Dehydrogenase/reductase SDR family member 7B Show all	Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins Phobius predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 1TM proteins predicted by MDM Protein evidence (Ezkurdia et al 2014) Show all	GO:0016021 [integral component of membrane] GO:0016491 [oxidoreductase activity] GO:0055114 [oxidation-reduction process] Show all	125 aa 13.6 kDa	No	1
DHRS7B-011 ENSP00000463221 ENST00000582161	J3QKT1 [Direct mapping] Dehydrogenase/reductase SDR family member 7B Show all	Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 1TM proteins predicted by MDM Protein evidence (Ezkurdia et al 2014) Show all	GO:0008152 [metabolic process] GO:0016021 [integral component of membrane] GO:0016491 [oxidoreductase activity] GO:0055114 [oxidation-reduction process] Show all	126 aa 13.4 kDa	No	1

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The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.