Expression of RCVRN in cancer - Summary

GENERAL INFORMATION
Gene name	RCVRN
Gene description	Recoverin
Protein class	Plasma proteins Predicted intracellular proteins
Predicted localization	Intracellular
Number of transcripts	1
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HUMAN PROTEIN ATLAS INFORMATION

RNA category

Protein evidence

Evidence at protein level

Protein expression
normal tissue

Strong cytoplasmic and nuclear expression in photoreceptor cells and subsets of cells in inner nuclear layer.

ANTIBODY IHC RELIABILITY
Data reliability description	External characterization data supports antibody staining but no internal RNA data available for correlation. Paired antibodies with high similarity supports the protein profile.
Reliability score	Supported based on 2 antibodies. HPA015783 , CAB022363
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PROGNOSTIC SUMMARY
Gene product is not prognostic.
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RNA EXPRESSION OVERVIEW
TCGA dataset RNA cancer category: Not detected

PROTEIN EXPRESSION

STAINING SUMMARY

HPA015783	CAB022363

GENE INFORMATION
Gene name	RCVRN (HGNC Symbol)
Synonyms	RCV1
Description	Recoverin (HGNC Symbol)
Entrez gene summary	This gene encodes a member of the recoverin family of neuronal calcium sensors. The encoded protein contains three calcium-binding EF-hand domains and may prolong the termination of the phototransduction cascade in the retina by blocking the phosphorylation of photo-activated rhodopsin. Recoverin may be the antigen responsible for cancer-associated retinopathy. [provided by RefSeq, Jul 2008]
Chromosome	17
Cytoband	p13.1
Chromosome location (bp)	9896320 - 9905621
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000109047 (version 83.38)
Entrez gene	5957
UniProt	P35243 (UniProt - Evidence at protein level)
neXtProt	NX_P35243
Antibodypedia	RCVRN antibodies

PROTEIN BROWSER

RCVRN-001

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
RCVRN-001 ENSP00000226193 ENST00000226193	P35243 [Direct mapping] Recoverin Show all	Predicted intracellular proteins Plasma proteins Protein evidence (Kim et al 2014) Show all	GO:0005509 [calcium ion binding] GO:0007165 [signal transduction] GO:0007601 [visual perception] GO:0007602 [phototransduction] GO:0007603 [phototransduction, visible light] GO:0008048 [calcium sensitive guanylate cyclase activator activity] GO:0016056 [rhodopsin mediated signaling pathway] GO:0022400 [regulation of rhodopsin mediated signaling pathway] GO:0031284 [positive regulation of guanylate cyclase activity] GO:0051924 [regulation of calcium ion transport] Show all	200 aa 23.1 kDa	No	0