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MYH1

GENERAL INFORMATION

Gene name

 MYH1

Gene description

 Myosin, heavy chain 1, skeletal muscle, adult

Protein class

 Plasma proteins
Predicted intracellular proteins

Predicted localization

 Intracellular

Number of transcripts

 1
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HUMAN PROTEIN ATLAS INFORMATION

RNA category
TCGA (cancer tissue):Tissue enriched (head and neck cancer)
HPA (cell line):Not detected
HPA (normal tissue):Tissue enriched (skeletal muscle)

Protein evidence

 Evidence at protein level

Protein expression
normal tissue

 Selective cytoplasmic expression in heart and skeletal muscle.

ANTIBODY IHC RELIABILITY

Data reliability
description

 Antibody staining mainly consistent with RNA expression data. Caution, targets protein from more than one gene.

Reliability score

 Supported based on 2 antibodies.
HPA001349 , CAB010759
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PROGNOSTIC SUMMARY
Gene product is not prognostic.
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RNA EXPRESSION OVERVIEW
TCGA dataset
RNA cancer category: Tissue enriched (head and neck cancer)

PROTEIN EXPRESSION
Colorectal cancer
Breast cancer
Prostate cancer
Lung cancer
Liver cancer

STAINING SUMMARY
HPA001349
CAB010759

GENE INFORMATION

Gene name

 MYH1 (HGNC Symbol)

Synonyms

 MGC133384, MYHa, MyHC-2X/D, MYHSA1

Description

 Myosin, heavy chain 1, skeletal muscle, adult (HGNC Symbol)

Entrez gene summary

 Myosin is a major contractile protein which converts chemical energy into mechanical energy through the hydrolysis of ATP. Myosin is a hexameric protein composed of a pair of myosin heavy chains (MYH) and two pairs of nonidentical light chains. Myosin heavy chains are encoded by a multigene family. In mammals at least 10 different myosin heavy chain (MYH) isoforms have been described from striated, smooth, and nonmuscle cells. These isoforms show expression that is spatially and temporally regulated during development. [provided by RefSeq, Jul 2008]

Chromosome

 17

Cytoband

 p13.1

Chromosome location (bp)

 10492307 - 10518543

Protein evidence

 Evidence at protein level (all genes)

Ensembl

 ENSG00000109061 (version 83.38)

Entrez gene

 4619

UniProt

 P12882 (UniProt - Evidence at protein level)

neXtProt

 NX_P12882

Antibodypedia

 MYH1 antibodies

PROTEIN BROWSER
MYH1-001

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)
MYH1-001
ENSP00000226207
ENST00000226207
P12882 [Direct mapping]
Myosin-1
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Predicted intracellular proteins
Plasma proteins
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
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GO:0003774 [motor activity]
GO:0003779 [actin binding]
GO:0005515 [protein binding]
GO:0005516 [calmodulin binding]
GO:0005524 [ATP binding]
GO:0005859 [muscle myosin complex]
GO:0008152 [metabolic process]
GO:0014704 [intercalated disc]
GO:0016459 [myosin complex]
GO:0031672 [A band]
GO:0032982 [myosin filament]
GO:0036464 [cytoplasmic ribonucleoprotein granule]
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 1939 aa
223.1 kDa 		No 0

Contact

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.