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TNFAIP1

GENERAL INFORMATION

Gene name

 TNFAIP1

Gene description

 Tumor necrosis factor, alpha-induced protein 1 (endothelial)

Protein class

 Predicted intracellular proteins

Predicted localization

 Intracellular

Number of transcripts

 5
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HUMAN PROTEIN ATLAS INFORMATION

RNA category
TCGA (cancer tissue):Expressed in all
HPA (cell line):Expressed in all
HPA (normal tissue):Expressed in all

Protein evidence

 Evidence at protein level

Protein expression
normal tissue

 Cytoplasmic expression in several tissues, including smooth muscle.

ANTIBODY IHC RELIABILITY

Data reliability
description

 Antibody staining mainly not consistent with RNA expression data. Pending external verification.

Reliability score

 Uncertain based on 2 antibodies.
HPA013333 , HPA014641
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PROGNOSTIC SUMMARY
Prognostic marker in endometrial cancer (unfavourable).
Endometrial cancer p<0.001
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RNA EXPRESSION OVERVIEW
TCGA dataset
RNA cancer category: Expressed in all

PROTEIN EXPRESSION
Colorectal cancer
Breast cancer
Prostate cancer
Lung cancer

STAINING SUMMARY
HPA013333
HPA014641

GENE INFORMATION

Gene name

 TNFAIP1 (HGNC Symbol)

Synonyms

 B12, B61, BTBD34, EDP1, MGC2317

Description

 Tumor necrosis factor, alpha-induced protein 1 (endothelial) (HGNC Symbol)

Entrez gene summary

 This gene was identified as a gene whose expression can be induced by the tumor necrosis factor alpha (TNF) in umbilical vein endothelial cells. Studies of a similar gene in mouse suggest that the expression of this gene is developmentally regulated in a tissue-specific manner. [provided by RefSeq, Jul 2008]

Chromosome

 17

Cytoband

 q11.2

Chromosome location (bp)

 28335602 - 28347009

Protein evidence

 Evidence at protein level (all genes)

Ensembl

 ENSG00000109079 (version 83.38)

Entrez gene

 7126

UniProt

 Q13829 (UniProt - Evidence at protein level)

neXtProt

 NX_Q13829

Antibodypedia

 TNFAIP1 antibodies

PROTEIN BROWSER
TNFAIP1-001
TNFAIP1-002
TNFAIP1-004
TNFAIP1-006
TNFAIP1-007

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)
TNFAIP1-001
ENSP00000226225
ENST00000226225
Q13829 [Direct mapping]
BTB/POZ domain-containing adapter for CUL3-mediated RhoA degradation protein 2
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Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
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GO:0004842 [ubiquitin-protein transferase activity]
GO:0005515 [protein binding]
GO:0005730 [nucleolus]
GO:0005737 [cytoplasm]
GO:0005768 [endosome]
GO:0006260 [DNA replication]
GO:0006915 [apoptotic process]
GO:0006955 [immune response]
GO:0009790 [embryo development]
GO:0016477 [cell migration]
GO:0016567 [protein ubiquitination]
GO:0017049 [GTP-Rho binding]
GO:0019904 [protein domain specific binding]
GO:0031463 [Cul3-RING ubiquitin ligase complex]
GO:0035024 [negative regulation of Rho protein signal transduction]
GO:0043149 [stress fiber assembly]
GO:0043161 [proteasome-mediated ubiquitin-dependent protein catabolic process]
GO:0045740 [positive regulation of DNA replication]
GO:0051260 [protein homooligomerization]
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 316 aa
36.2 kDa 		No 0
TNFAIP1-002
ENSP00000440749
ENST00000544907
Q13829 [Direct mapping]
BTB/POZ domain-containing adapter for CUL3-mediated RhoA degradation protein 2
Show all
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0004842 [ubiquitin-protein transferase activity]
GO:0005515 [protein binding]
GO:0005730 [nucleolus]
GO:0005737 [cytoplasm]
GO:0005768 [endosome]
GO:0006260 [DNA replication]
GO:0006915 [apoptotic process]
GO:0006955 [immune response]
GO:0009790 [embryo development]
GO:0016477 [cell migration]
GO:0016567 [protein ubiquitination]
GO:0017049 [GTP-Rho binding]
GO:0031463 [Cul3-RING ubiquitin ligase complex]
GO:0035024 [negative regulation of Rho protein signal transduction]
GO:0043149 [stress fiber assembly]
GO:0043161 [proteasome-mediated ubiquitin-dependent protein catabolic process]
GO:0051260 [protein homooligomerization]
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 212 aa
24.7 kDa 		No 0
TNFAIP1-004
ENSP00000464515
ENST00000582302
J3QS43 [Direct mapping]
BTB/POZ domain-containing adapter for CUL3-mediated RhoA degradation protein 2
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Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
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GO:0005515 [protein binding]
GO:0051260 [protein homooligomerization]
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 125 aa
13.9 kDa 		No 0
TNFAIP1-006
ENSP00000466301
ENST00000577535
K7EM01 [Direct mapping]
BTB/POZ domain-containing adapter for CUL3-mediated RhoA degradation protein 2
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Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
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 157 aa
17.8 kDa 		No 0
TNFAIP1-007
ENSP00000464637
ENST00000578158
J3QSD4 [Direct mapping]
BTB/POZ domain-containing adapter for CUL3-mediated RhoA degradation protein 2
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Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0005515 [protein binding]
GO:0051260 [protein homooligomerization]
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 107 aa
11.8 kDa 		No 0

Contact

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.