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RAB34

GENERAL INFORMATION

Gene name

 RAB34

Gene description

 RAB34, member RAS oncogene family

Protein class

 Predicted intracellular proteins

Predicted localization

 Intracellular

Number of transcripts

 16
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HUMAN PROTEIN ATLAS INFORMATION

RNA category
TCGA (cancer tissue):Expressed in all
HPA (cell line):Mixed
HPA (normal tissue):Expressed in all

Protein evidence

 Evidence at protein level

Protein expression
normal tissue

 General cytoplasmic expression.

ANTIBODY IHC RELIABILITY

Data reliability
description

 Antibody staining mainly not consistent with RNA expression data.

Reliability score

 Approved based on 1 antibody.
HPA021366
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PROGNOSTIC SUMMARY
Prognostic marker in renal cancer (unfavourable) and thyroid cancer (favourable).
Renal cancer p<0.001
Thyroid cancer p<0.001
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RNA EXPRESSION OVERVIEW
TCGA dataset
RNA cancer category: Expressed in all

PROTEIN EXPRESSION
Colorectal cancer
Breast cancer
Prostate cancer
Lung cancer
Liver cancer

STAINING SUMMARY
HPA021366

GENE INFORMATION

Gene name

 RAB34 (HGNC Symbol)

Synonyms

 RAB39, RAH

Description

 RAB34, member RAS oncogene family (HGNC Symbol)

Entrez gene summary

 This gene encodes a protein belonging to the RAB family of proteins, which are small GTPases involved in protein transport. This family member is a Golgi-bound member of the secretory pathway that is involved in the repositioning of lysosomes and the activation of macropinocytosis. Alternative splicing of this gene results in multiple transcript variants. This gene overlaps and shares exon structure with the nine-amino acid residue-repeats (NARR) gene, which encodes a functionally distinct nucleolar protein from a different reading frame. [provided by RefSeq, Jan 2012]

Chromosome

 17

Cytoband

 q11.2

Chromosome location (bp)

 28714281 - 28718429

Protein evidence

 Evidence at protein level (all genes)

Ensembl

 ENSG00000109113 (version 83.38)

Entrez gene

 83871

UniProt

 Q9BZG1 (UniProt - Evidence at protein level)

neXtProt

 NX_Q9BZG1

Antibodypedia

 RAB34 antibodies

PROTEIN BROWSER
«
RAB34-001
RAB34-002
RAB34-003
RAB34-004
RAB34-005
RAB34-006
RAB34-007
RAB34-008
RAB34-009
RAB34-010
RAB34-018
RAB34-019
RAB34-020
RAB34-021
RAB34-022
RAB34-201
»

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)
RAB34-001
ENSP00000301043
ENST00000301043
Q9BZG1 [Direct mapping]
Ras-related protein Rab-34
A0A024QZ68 [Target identity:100%; Query identity:100%]
RAB34, member RAS oncogene family, isoform CRA_b
Show all
Predicted intracellular proteins
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0003924 [GTPase activity]
GO:0005515 [protein binding]
GO:0005525 [GTP binding]
GO:0005622 [intracellular]
GO:0005794 [Golgi apparatus]
GO:0005795 [Golgi stack]
GO:0006886 [intracellular protein transport]
GO:0006913 [nucleocytoplasmic transport]
GO:0007165 [signal transduction]
GO:0007264 [small GTPase mediated signal transduction]
GO:0015031 [protein transport]
GO:0016020 [membrane]
GO:0017160 [Ral GTPase binding]
GO:0019882 [antigen processing and presentation]
GO:0030670 [phagocytic vesicle membrane]
GO:0031982 [vesicle]
GO:0031985 [Golgi cisterna]
GO:0032418 [lysosome localization]
GO:0032482 [Rab protein signal transduction]
GO:0043001 [Golgi to plasma membrane protein transport]
GO:0045335 [phagocytic vesicle]
GO:0048471 [perinuclear region of cytoplasm]
GO:0070062 [extracellular exosome]
GO:0072659 [protein localization to plasma membrane]
GO:0090382 [phagosome maturation]
GO:0090385 [phagosome-lysosome fusion]
Show all
 259 aa
29 kDa 		No 0
RAB34-002
ENSP00000487160
ENST00000625712
Q96PJ7 [Direct mapping]
Ras-related GTP-binding protein RAB39; Ras-related protein Rab-34, isoform NARR
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Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0003924 [GTPase activity]
GO:0005525 [GTP binding]
GO:0005622 [intracellular]
GO:0007165 [signal transduction]
GO:0007264 [small GTPase mediated signal transduction]
GO:0015031 [protein transport]
GO:0016020 [membrane]
GO:0032482 [Rab protein signal transduction]
Show all
 211 aa
23.8 kDa 		No 0
RAB34-003
ENSP00000404180
ENST00000436730
Q9BZG1 [Direct mapping]
Ras-related protein Rab-34
A0A024QZ68 [Target identity:100%; Query identity:100%]
RAB34, member RAS oncogene family, isoform CRA_b
Show all
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0003924 [GTPase activity]
GO:0005515 [protein binding]
GO:0005525 [GTP binding]
GO:0005622 [intracellular]
GO:0005794 [Golgi apparatus]
GO:0005795 [Golgi stack]
GO:0006886 [intracellular protein transport]
GO:0006913 [nucleocytoplasmic transport]
GO:0007165 [signal transduction]
GO:0007264 [small GTPase mediated signal transduction]
GO:0015031 [protein transport]
GO:0016020 [membrane]
GO:0017160 [Ral GTPase binding]
GO:0019882 [antigen processing and presentation]
GO:0030670 [phagocytic vesicle membrane]
GO:0031982 [vesicle]
GO:0031985 [Golgi cisterna]
GO:0032418 [lysosome localization]
GO:0032482 [Rab protein signal transduction]
GO:0043001 [Golgi to plasma membrane protein transport]
GO:0045335 [phagocytic vesicle]
GO:0048471 [perinuclear region of cytoplasm]
GO:0070062 [extracellular exosome]
GO:0072659 [protein localization to plasma membrane]
GO:0090382 [phagosome maturation]
GO:0090385 [phagosome-lysosome fusion]
Show all
 259 aa
29 kDa 		No 0
RAB34-004
ENSP00000226259
ENST00000353676
C9JBG0 [Direct mapping]
Ras-related protein Rab-34, isoform NARR
Show all
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0003924 [GTPase activity]
GO:0005525 [GTP binding]
GO:0005622 [intracellular]
GO:0007165 [signal transduction]
GO:0007264 [small GTPase mediated signal transduction]
GO:0015031 [protein transport]
GO:0016020 [membrane]
GO:0032482 [Rab protein signal transduction]
Show all
 211 aa
23.9 kDa 		No 0
RAB34-005
ENSP00000378664
ENST00000395243
Q9BZG1 [Direct mapping]
Ras-related protein Rab-34
Show all
Predicted intracellular proteins
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0003924 [GTPase activity]
GO:0005515 [protein binding]
GO:0005525 [GTP binding]
GO:0005622 [intracellular]
GO:0005794 [Golgi apparatus]
GO:0005795 [Golgi stack]
GO:0006886 [intracellular protein transport]
GO:0006913 [nucleocytoplasmic transport]
GO:0007165 [signal transduction]
GO:0007264 [small GTPase mediated signal transduction]
GO:0015031 [protein transport]
GO:0016020 [membrane]
GO:0017160 [Ral GTPase binding]
GO:0019882 [antigen processing and presentation]
GO:0030670 [phagocytic vesicle membrane]
GO:0031982 [vesicle]
GO:0031985 [Golgi cisterna]
GO:0032418 [lysosome localization]
GO:0032482 [Rab protein signal transduction]
GO:0043001 [Golgi to plasma membrane protein transport]
GO:0045335 [phagocytic vesicle]
GO:0048471 [perinuclear region of cytoplasm]
GO:0070062 [extracellular exosome]
GO:0072659 [protein localization to plasma membrane]
GO:0090382 [phagosome maturation]
GO:0090385 [phagosome-lysosome fusion]
Show all
 251 aa
28.2 kDa 		No 0
RAB34-006
ENSP00000378663
ENST00000395242
A8MYQ9 [Direct mapping]
Ras-related protein Rab-34, isoform NARR
Show all
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0003924 [GTPase activity]
GO:0005525 [GTP binding]
GO:0005622 [intracellular]
GO:0006886 [intracellular protein transport]
GO:0006913 [nucleocytoplasmic transport]
GO:0007165 [signal transduction]
GO:0007264 [small GTPase mediated signal transduction]
GO:0015031 [protein transport]
GO:0016020 [membrane]
GO:0032482 [Rab protein signal transduction]
Show all
 260 aa
29.2 kDa 		No 0
RAB34-007
ENSP00000410279
ENST00000415040
Q9BZG1 [Direct mapping]
Ras-related protein Rab-34
Show all
Predicted intracellular proteins
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0003924 [GTPase activity]
GO:0005515 [protein binding]
GO:0005525 [GTP binding]
GO:0005622 [intracellular]
GO:0005794 [Golgi apparatus]
GO:0005795 [Golgi stack]
GO:0007165 [signal transduction]
GO:0007264 [small GTPase mediated signal transduction]
GO:0015031 [protein transport]
GO:0016020 [membrane]
GO:0017160 [Ral GTPase binding]
GO:0019882 [antigen processing and presentation]
GO:0030670 [phagocytic vesicle membrane]
GO:0031982 [vesicle]
GO:0031985 [Golgi cisterna]
GO:0032418 [lysosome localization]
GO:0032482 [Rab protein signal transduction]
GO:0043001 [Golgi to plasma membrane protein transport]
GO:0045335 [phagocytic vesicle]
GO:0048471 [perinuclear region of cytoplasm]
GO:0070062 [extracellular exosome]
GO:0072659 [protein localization to plasma membrane]
GO:0090382 [phagosome maturation]
GO:0090385 [phagosome-lysosome fusion]
Show all
 237 aa
26.7 kDa 		No 0
RAB34-008
ENSP00000391048
ENST00000450529
Q9BZG1 [Direct mapping]
Ras-related protein Rab-34
Show all
Predicted intracellular proteins
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0003924 [GTPase activity]
GO:0005515 [protein binding]
GO:0005525 [GTP binding]
GO:0005622 [intracellular]
GO:0005794 [Golgi apparatus]
GO:0005795 [Golgi stack]
GO:0006886 [intracellular protein transport]
GO:0006913 [nucleocytoplasmic transport]
GO:0007165 [signal transduction]
GO:0007264 [small GTPase mediated signal transduction]
GO:0015031 [protein transport]
GO:0016020 [membrane]
GO:0017160 [Ral GTPase binding]
GO:0019882 [antigen processing and presentation]
GO:0030670 [phagocytic vesicle membrane]
GO:0031982 [vesicle]
GO:0031985 [Golgi cisterna]
GO:0032418 [lysosome localization]
GO:0032482 [Rab protein signal transduction]
GO:0043001 [Golgi to plasma membrane protein transport]
GO:0045335 [phagocytic vesicle]
GO:0048471 [perinuclear region of cytoplasm]
GO:0070062 [extracellular exosome]
GO:0072659 [protein localization to plasma membrane]
GO:0090382 [phagosome maturation]
GO:0090385 [phagosome-lysosome fusion]
Show all
 251 aa
28.2 kDa 		No 0
RAB34-009
ENSP00000398706
ENST00000412625
C9JBG0 [Direct mapping]
Ras-related protein Rab-34, isoform NARR
Show all
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0003924 [GTPase activity]
GO:0005525 [GTP binding]
GO:0005622 [intracellular]
GO:0007165 [signal transduction]
GO:0007264 [small GTPase mediated signal transduction]
GO:0015031 [protein transport]
GO:0016020 [membrane]
GO:0032482 [Rab protein signal transduction]
Show all
 211 aa
23.9 kDa 		No 0
RAB34-010
ENSP00000407953
ENST00000430132
C9JY26 [Direct mapping]
Ras-related protein Rab-34, isoform NARR
Show all
Predicted intracellular proteins
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0003924 [GTPase activity]
GO:0005525 [GTP binding]
GO:0005622 [intracellular]
GO:0006886 [intracellular protein transport]
GO:0006913 [nucleocytoplasmic transport]
GO:0007165 [signal transduction]
GO:0007264 [small GTPase mediated signal transduction]
GO:0008152 [metabolic process]
GO:0015031 [protein transport]
GO:0016020 [membrane]
GO:0032482 [Rab protein signal transduction]
Show all
 259 aa
28.9 kDa 		No 0
RAB34-018
ENSP00000378666
ENST00000395245
Q9BZG1 [Direct mapping]
Ras-related protein Rab-34
A0A024QZ68 [Target identity:100%; Query identity:100%]
RAB34, member RAS oncogene family, isoform CRA_b
Show all
Predicted intracellular proteins
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0003924 [GTPase activity]
GO:0005515 [protein binding]
GO:0005525 [GTP binding]
GO:0005622 [intracellular]
GO:0005794 [Golgi apparatus]
GO:0005795 [Golgi stack]
GO:0006886 [intracellular protein transport]
GO:0006913 [nucleocytoplasmic transport]
GO:0007165 [signal transduction]
GO:0007264 [small GTPase mediated signal transduction]
GO:0015031 [protein transport]
GO:0016020 [membrane]
GO:0017160 [Ral GTPase binding]
GO:0019882 [antigen processing and presentation]
GO:0030670 [phagocytic vesicle membrane]
GO:0031982 [vesicle]
GO:0031985 [Golgi cisterna]
GO:0032418 [lysosome localization]
GO:0032482 [Rab protein signal transduction]
GO:0043001 [Golgi to plasma membrane protein transport]
GO:0045335 [phagocytic vesicle]
GO:0048471 [perinuclear region of cytoplasm]
GO:0070062 [extracellular exosome]
GO:0072659 [protein localization to plasma membrane]
GO:0090382 [phagosome maturation]
GO:0090385 [phagosome-lysosome fusion]
Show all
 259 aa
29 kDa 		No 0
RAB34-019
ENSP00000464723
ENST00000419712
K7EIF2 [Direct mapping]
Ras-related protein Rab-34, isoform NARR
Show all
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0003924 [GTPase activity]
GO:0005525 [GTP binding]
GO:0005622 [intracellular]
GO:0007264 [small GTPase mediated signal transduction]
GO:0015031 [protein transport]
GO:0032482 [Rab protein signal transduction]
Show all
 149 aa
16.9 kDa 		No 0
RAB34-020
ENSP00000465352
ENST00000580843
K7EJW7 [Direct mapping]
Ras-related protein Rab-34, isoform NARR
Show all
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0003924 [GTPase activity]
GO:0005622 [intracellular]
GO:0032482 [Rab protein signal transduction]
Show all
 51 aa
5.8 kDa 		No 0
RAB34-021
ENSP00000476427
ENST00000582934
V9GY61 [Direct mapping]
Ras-related protein Rab-34, isoform NARR
Show all
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0003924 [GTPase activity]
GO:0005622 [intracellular]
GO:0032482 [Rab protein signal transduction]
Show all
 49 aa
5.5 kDa 		No 0
RAB34-022
ENSP00000463488
ENST00000583538
J3QLC6 [Direct mapping]
Ras-related protein Rab-34, isoform NARR
Show all
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0003924 [GTPase activity]
GO:0005525 [GTP binding]
GO:0005622 [intracellular]
GO:0007264 [small GTPase mediated signal transduction]
GO:0015031 [protein transport]
GO:0032482 [Rab protein signal transduction]
Show all
 156 aa
17.4 kDa 		No 0
RAB34-201
ENSP00000413156
ENST00000453384
E7ES60 [Direct mapping]
Ras-related protein Rab-34, isoform NARR
Show all
Predicted intracellular proteins
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0001726 [ruffle]
GO:0003924 [GTPase activity]
GO:0005515 [protein binding]
GO:0005525 [GTP binding]
GO:0005622 [intracellular]
GO:0005769 [early endosome]
GO:0006897 [endocytosis]
GO:0007165 [signal transduction]
GO:0007264 [small GTPase mediated signal transduction]
GO:0015031 [protein transport]
GO:0016020 [membrane]
GO:0019001 [guanyl nucleotide binding]
GO:0032482 [Rab protein signal transduction]
Show all
 268 aa
29.9 kDa 		No 0

Contact

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.