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Thyroid cancers and several cases of malignant melanomas, prostate, endometrial and liver cancers showed moderate to strong cytoplasmic positivity combined with a granular pattern in a few cases. Remaining cancer tissues were in general weakly stained or negative.
GENE INFORMATION
Gene name
RAB34 (HGNC Symbol)
Synonyms
RAB39, RAH
Description
RAB34, member RAS oncogene family (HGNC Symbol)
Entrez gene summary
This gene encodes a protein belonging to the RAB family of proteins, which are small GTPases involved in protein transport. This family member is a Golgi-bound member of the secretory pathway that is involved in the repositioning of lysosomes and the activation of macropinocytosis. Alternative splicing of this gene results in multiple transcript variants. This gene overlaps and shares exon structure with the nine-amino acid residue-repeats (NARR) gene, which encodes a functionally distinct nucleolar protein from a different reading frame. [provided by RefSeq, Jan 2012]