Expression of UGT2B10 in cancer - Summary - The Human Protein Atlas

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UGT2B10

TISSUE

CELL

PATHOLOGY

PATHOLOGY ATLAS

GENE/PROTEIN

Antibody validation

Dictionary


Level of antibody staining/expression
	High Medium Low Not detected

GENERAL INFORMATION
Gene name	UGT2B10
Gene description	UDP glucuronosyltransferase 2 family, polypeptide B10
Protein class	Enzymes Predicted membrane proteins
Predicted localization	Membrane
Number of transcripts	2
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HUMAN PROTEIN ATLAS INFORMATION

RNA category

TCGA (cancer tissue):	Tissue enriched (liver cancer)
HPA (cell line):	Cell line enriched (Hep G2)
HPA (normal tissue):	Tissue enriched (liver)

Protein evidence

Evidence at protein level

Protein expression
normal tissue

Estimation of protein expression could not be performed. View primary data.

ANTIBODY IHC RELIABILITY
Data reliability description	RNA-based expert annotation gave inconclusive results. Pending external verification. Caution, targets protein from more than one gene. Antibody staining not consistent with RNA expression data.
Reliability score	Uncertain based on 1 antibody. HPA045108
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PROGNOSTIC SUMMARY
Gene product is not prognostic.
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RNA EXPRESSION OVERVIEW
TCGA dataset RNA cancer category: Tissue enriched (liver cancer)

PROTEIN EXPRESSION

Colorectal cancer

Prostate cancer

STAINING SUMMARY

HPA045108

GENE INFORMATION
Gene name	UGT2B10
Synonyms
Description	UDP glucuronosyltransferase 2 family, polypeptide B10 (HGNC Symbol)
Entrez gene summary
Chromosome	4
Cytoband	q13.2
Chromosome location (bp)	68815993 - 68831196
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000109181 (version 83.38)
Entrez gene	7365
UniProt	P36537 (UniProt - Evidence at protein level)
neXtProt	NX_P36537
Antibodypedia	UGT2B10 antibodies

PROTEIN BROWSER

UGT2B10-001	UGT2B10-002

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
UGT2B10-001 ENSP00000265403 ENST00000265403	P36537 [Direct mapping] UDP-glucuronosyltransferase 2B10 Show all	Enzymes ENZYME proteins Transferases Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 1TM proteins predicted by MDM Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0005789 [endoplasmic reticulum membrane] GO:0006629 [lipid metabolic process] GO:0008152 [metabolic process] GO:0009813 [flavonoid biosynthetic process] GO:0015020 [glucuronosyltransferase activity] GO:0016021 [integral component of membrane] GO:0016758 [transferase activity, transferring hexosyl groups] GO:0032870 [cellular response to hormone stimulus] GO:0043231 [intracellular membrane-bounded organelle] GO:0052696 [flavonoid glucuronidation] Show all	528 aa 60.8 kDa	Yes	1
UGT2B10-002 ENSP00000413420 ENST00000458688	P36537 [Direct mapping] UDP-glucuronosyltransferase 2B10 Show all	Enzymes ENZYME proteins Transferases Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 1TM proteins predicted by MDM Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0005789 [endoplasmic reticulum membrane] GO:0006629 [lipid metabolic process] GO:0008152 [metabolic process] GO:0009813 [flavonoid biosynthetic process] GO:0015020 [glucuronosyltransferase activity] GO:0016021 [integral component of membrane] GO:0016758 [transferase activity, transferring hexosyl groups] GO:0032870 [cellular response to hormone stimulus] GO:0043231 [intracellular membrane-bounded organelle] GO:0052696 [flavonoid glucuronidation] Show all	444 aa 50.7 kDa	Yes	1

Contact

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The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.