Expression of NMU in cancer - Summary - The Human Protein Atlas

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NMU

TISSUE

CELL

PATHOLOGY

PATHOLOGY ATLAS

GENE/PROTEIN

Antibody validation

Dictionary


Level of antibody staining/expression
	High Medium Low Not detected

GENERAL INFORMATION
Gene name	NMU
Gene description	Neuromedin U
Protein class	Predicted secreted proteins
Predicted localization	Secreted
Number of transcripts	4
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HUMAN PROTEIN ATLAS INFORMATION

RNA category

TCGA (cancer tissue):	Mixed
HPA (cell line):	Cell line enhanced (HaCaT, K-562)
HPA (normal tissue):	Group enriched (esophagus, skin)

Protein evidence

Evidence at protein level

Protein expression
normal tissue

Estimation of protein expression could not be performed. View primary data.

ANTIBODY IHC RELIABILITY
Data reliability description	RNA-based expert annotation gave inconclusive results. Secreted protein, tissue location of RNA and protein might differ and correlation is complex. Pending external verification.
Reliability score	Uncertain based on 1 antibody. HPA025926
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PROGNOSTIC SUMMARY
Prognostic marker in renal cancer (unfavourable) and endometrial cancer (unfavourable).
Renal cancer p<0.001 Endometrial cancer p<0.001 Show all

RNA EXPRESSION OVERVIEW
TCGA dataset RNA cancer category: Mixed

PROTEIN EXPRESSION

Colorectal cancer

Prostate cancer

STAINING SUMMARY

HPA025926

GENE INFORMATION
Gene name	NMU
Synonyms
Description	Neuromedin U (HGNC Symbol)
Entrez gene summary	This gene encodes a member of the neuromedin family of neuropeptides. The encoded protein is a precursor that is proteolytically processed to generate a biologically active neuropeptide that plays a role in pain, stress, immune-mediated inflammatory diseases and feeding regulation. Increased expression of this gene was observed in renal, pancreatic and lung cancers. Alternative splicing results in multiple transcript variants encoding different isoforms. Some of these isoforms may undergo similar processing to generate the mature peptide. [provided by RefSeq, Jul 2015]
Chromosome	4
Cytoband	q12
Chromosome location (bp)	55595229 - 55636698
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000109255 (version 83.38)
Entrez gene	10874
UniProt	P48645 (UniProt - Evidence at protein level)
neXtProt	NX_P48645
Antibodypedia	NMU antibodies

PROTEIN BROWSER

NMU-001	NMU-002	NMU-003	NMU-005

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
NMU-001 ENSP00000264218 ENST00000264218	P48645 [Direct mapping] Neuromedin-U Neuromedin-U-25 Show all	MEMSAT3 predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins Predicted secreted proteins Secreted proteins predicted by MDSEC SignalP predicted secreted proteins Phobius predicted secreted proteins SPOCTOPUS predicted secreted proteins Show all	GO:0001696 [gastric acid secretion] GO:0005102 [receptor binding] GO:0005515 [protein binding] GO:0005576 [extracellular region] GO:0006940 [regulation of smooth muscle contraction] GO:0007165 [signal transduction] GO:0007186 [G-protein coupled receptor signaling pathway] GO:0007218 [neuropeptide signaling pathway] GO:0007586 [digestion] GO:0009648 [photoperiodism] GO:0019233 [sensory perception of pain] GO:0042755 [eating behavior] GO:0042922 [neuromedin U receptor binding] GO:0043195 [terminal bouton] GO:0045987 [positive regulation of smooth muscle contraction] GO:0046887 [positive regulation of hormone secretion] GO:0050806 [positive regulation of synaptic transmission] Show all	174 aa 19.7 kDa	Yes	0
NMU-002 ENSP00000422399 ENST00000511469	A0A0B4J202 [Direct mapping] Neuromedin-U Show all	MEMSAT3 predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins Predicted secreted proteins Secreted proteins predicted by MDSEC SignalP predicted secreted proteins Phobius predicted secreted proteins SPOCTOPUS predicted secreted proteins Show all	GO:0006940 [regulation of smooth muscle contraction] Show all	158 aa 18 kDa	Yes	0
NMU-003 ENSP00000422870 ENST00000507338	E9PDJ7 [Direct mapping] Neuromedin-U Show all	MEMSAT3 predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins Predicted secreted proteins Secreted proteins predicted by MDSEC SignalP predicted secreted proteins Phobius predicted secreted proteins SPOCTOPUS predicted secreted proteins Show all	GO:0006940 [regulation of smooth muscle contraction] Show all	149 aa 16.7 kDa	Yes	0
NMU-005 ENSP00000424246 ENST00000505262	D6RBC9 [Direct mapping] Neuromedin U, isoform CRA_a; Neuromedin-U Show all	MEMSAT3 predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins Predicted secreted proteins Secreted proteins predicted by MDSEC SignalP predicted secreted proteins Phobius predicted secreted proteins SPOCTOPUS predicted secreted proteins Show all	GO:0006940 [regulation of smooth muscle contraction] Show all	147 aa 16.5 kDa	Yes	0

Contact

contact@proteinatlas.org

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.