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MANBA

GENERAL INFORMATION

Gene name

 MANBA

Gene description

 Mannosidase, beta A, lysosomal

Protein class

 Disease related genes
Enzymes
Plasma proteins
Potential drug targets
Predicted secreted proteins

Predicted localization

 Secreted

Number of transcripts

 2
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HUMAN PROTEIN ATLAS INFORMATION

RNA category
TCGA (cancer tissue):Expressed in all
HPA (cell line):Expressed in all
HPA (normal tissue):Expressed in all

Protein evidence

 Evidence at protein level

Protein expression
normal tissue

 Cytoplasmic expression with a granular pattern in most tissues.

ANTIBODY IHC RELIABILITY

Data reliability
description

 Antibody staining mainly not consistent with RNA expression data. Pending external verification.

Reliability score

 Approved based on 1 antibody.
HPA053478
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PROGNOSTIC SUMMARY
Prognostic marker in liver cancer (unfavourable) and glioma (unfavourable).
Liver cancer p<0.001
Glioma p<0.001
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RNA EXPRESSION OVERVIEW
TCGA dataset
RNA cancer category: Expressed in all

PROTEIN EXPRESSION
Colorectal cancer
Breast cancer
Prostate cancer
Lung cancer
Liver cancer

STAINING SUMMARY
HPA053478

GENE INFORMATION

Gene name

 MANBA

Synonyms

Description

 Mannosidase, beta A, lysosomal (HGNC Symbol)

Entrez gene summary

 This gene encodes a member of the glycosyl hydrolase 2 family. The encoded protein localizes to the lysosome where it is the final exoglycosidase in the pathway for N-linked glycoprotein oligosaccharide catabolism. Mutations in this gene are associated with beta-mannosidosis, a lysosomal storage disease that has a wide spectrum of neurological involvement. [provided by RefSeq, Jul 2008]

Chromosome

 4

Cytoband

 q24

Chromosome location (bp)

 102631488 - 102760994

Protein evidence

 Evidence at protein level (all genes)

Ensembl

 ENSG00000109323 (version 83.38)

Entrez gene

 4126

UniProt

 O00462 (UniProt - Evidence at transcript level)

neXtProt

 NX_O00462

Antibodypedia

 MANBA antibodies

PROTEIN BROWSER
MANBA-001
MANBA-002

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)
MANBA-001
ENSP00000226578
ENST00000226578
O00462 [Direct mapping]
Beta-mannosidase
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Enzymes
   ENZYME proteins
   Hydrolases
Predicted secreted proteins
   Secreted proteins predicted by MDSEC
   SignalP predicted secreted proteins
   Phobius predicted secreted proteins
   SPOCTOPUS predicted secreted proteins
Plasma proteins
Disease related genes
Potential drug targets
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0004553 [hydrolase activity, hydrolyzing O-glycosyl compounds]
GO:0004567 [beta-mannosidase activity]
GO:0005537 [mannose binding]
GO:0005764 [lysosome]
GO:0005975 [carbohydrate metabolic process]
GO:0006464 [cellular protein modification process]
GO:0006516 [glycoprotein catabolic process]
GO:0043231 [intracellular membrane-bounded organelle]
GO:0046355 [mannan catabolic process]
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 879 aa
100.9 kDa 		Yes 0
MANBA-002
ENSP00000427322
ENST00000505239
E9PFW2 [Direct mapping]
Beta-mannosidase
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Predicted secreted proteins
   Secreted proteins predicted by MDSEC
   SignalP predicted secreted proteins
   Phobius predicted secreted proteins
   SPOCTOPUS predicted secreted proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0004553 [hydrolase activity, hydrolyzing O-glycosyl compounds]
GO:0005975 [carbohydrate metabolic process]
GO:0043231 [intracellular membrane-bounded organelle]
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 822 aa
94.4 kDa 		Yes 0

Contact

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.