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UBE2D3

GENERAL INFORMATION

Gene name

 UBE2D3

Gene description

 Ubiquitin-conjugating enzyme E2D 3

Protein class

 Enzymes
Predicted intracellular proteins

Predicted localization

 Intracellular

Number of transcripts

 19
SHOW MORE

HUMAN PROTEIN ATLAS INFORMATION

RNA category
TCGA (cancer tissue):Expressed in all
HPA (cell line):Expressed in all
HPA (normal tissue):Expressed in all

Protein evidence

 Evidence at protein level

Protein expression
normal tissue

 Cytoplasmic and nuclear membranous expression in most tissues.

ANTIBODY IHC RELIABILITY

Data reliability
description

 Antibody staining mainly consistent with RNA expression data. Caution, targets protein from more than one gene.

Reliability score

 Uncertain based on 1 antibody.
HPA003920
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PROGNOSTIC SUMMARY
Prognostic marker in renal cancer (favourable).
Renal cancer p<0.001
Show all

RNA EXPRESSION OVERVIEW
TCGA dataset
RNA cancer category: Expressed in all

PROTEIN EXPRESSION
Colorectal cancer
Breast cancer
Prostate cancer
Lung cancer
Liver cancer

STAINING SUMMARY
HPA003920

GENE INFORMATION

Gene name

 UBE2D3 (HGNC Symbol)

Synonyms

 UbcH5C

Description

 Ubiquitin-conjugating enzyme E2D 3 (HGNC Symbol)

Entrez gene summary

 The modification of proteins with ubiquitin is an important cellular mechanism for targeting abnormal or short-lived proteins for degradation. Ubiquitination involves at least three classes of enzymes: ubiquitin-activating enzymes, or E1s, ubiquitin-conjugating enzymes, or E2s, and ubiquitin-protein ligases, or E3s. This gene encodes a member of the E2 ubiquitin-conjugating enzyme family. This enzyme functions in the ubiquitination of the tumor-suppressor protein p53, which is induced by an E3 ubiquitin-protein ligase. Multiple spliced transcript variants have been found for this gene, but the full-length nature of some variants has not been determined. [provided by RefSeq, Jul 2008]

Chromosome

 4

Cytoband

 q24

Chromosome location (bp)

 102794383 - 102868896

Protein evidence

 Evidence at protein level (all genes)

Ensembl

 ENSG00000109332 (version 83.38)

Entrez gene

 7323

UniProt

 P61077 (UniProt - Evidence at protein level)

neXtProt

 NX_P61077

Antibodypedia

 UBE2D3 antibodies

PROTEIN BROWSER
«
UBE2D3-001
UBE2D3-002
UBE2D3-003
UBE2D3-004
UBE2D3-005
UBE2D3-006
UBE2D3-009
UBE2D3-010
UBE2D3-011
UBE2D3-012
UBE2D3-013
UBE2D3-014
UBE2D3-015
UBE2D3-016
UBE2D3-017
UBE2D3-018
UBE2D3-019
UBE2D3-201
UBE2D3-202
»

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)
UBE2D3-001
ENSP00000396901
ENST00000453744
P61077 [Direct mapping]
Ubiquitin-conjugating enzyme E2 D3
A0A024RDH2 [Target identity:100%; Query identity:100%]
Ubiquitin-conjugating enzyme E2D 3 (UBC4/5 homolog, yeast), isoform CRA_a
Show all
Enzymes
   ENZYME proteins
   Transferases
Predicted intracellular proteins
Protein evidence (Kim et al 2014)
Show all
GO:0000122 [negative regulation of transcription from RNA polymerase II promoter]
GO:0000209 [protein polyubiquitination]
GO:0002224 [toll-like receptor signaling pathway]
GO:0002756 [MyD88-independent toll-like receptor signaling pathway]
GO:0004842 [ubiquitin-protein transferase activity]
GO:0005515 [protein binding]
GO:0005524 [ATP binding]
GO:0005654 [nucleoplasm]
GO:0005829 [cytosol]
GO:0005886 [plasma membrane]
GO:0006281 [DNA repair]
GO:0006351 [transcription, DNA-templated]
GO:0006367 [transcription initiation from RNA polymerase II promoter]
GO:0006464 [cellular protein modification process]
GO:0006511 [ubiquitin-dependent protein catabolic process]
GO:0006513 [protein monoubiquitination]
GO:0006915 [apoptotic process]
GO:0007179 [transforming growth factor beta receptor signaling pathway]
GO:0010008 [endosome membrane]
GO:0010467 [gene expression]
GO:0016567 [protein ubiquitination]
GO:0030509 [BMP signaling pathway]
GO:0032480 [negative regulation of type I interferon production]
GO:0034138 [toll-like receptor 3 signaling pathway]
GO:0034142 [toll-like receptor 4 signaling pathway]
GO:0035666 [TRIF-dependent toll-like receptor signaling pathway]
GO:0043161 [proteasome-mediated ubiquitin-dependent protein catabolic process]
GO:0045087 [innate immune response]
GO:0051865 [protein autoubiquitination]
GO:0061418 [regulation of transcription from RNA polymerase II promoter in response to hypoxia]
GO:0061631 [ubiquitin conjugating enzyme activity]
GO:0070062 [extracellular exosome]
GO:0070936 [protein K48-linked ubiquitination]
GO:0070979 [protein K11-linked ubiquitination]
GO:0071456 [cellular response to hypoxia]
GO:1903955 [positive regulation of protein targeting to mitochondrion]
Show all
 147 aa
16.7 kDa 		No 0
UBE2D3-002
ENSP00000345285
ENST00000343106
P61077 [Direct mapping]
Ubiquitin-conjugating enzyme E2 D3
Show all
Enzymes
   ENZYME proteins
   Transferases
Predicted intracellular proteins
Protein evidence (Kim et al 2014)
Show all
GO:0000122 [negative regulation of transcription from RNA polymerase II promoter]
GO:0000209 [protein polyubiquitination]
GO:0002224 [toll-like receptor signaling pathway]
GO:0002756 [MyD88-independent toll-like receptor signaling pathway]
GO:0004842 [ubiquitin-protein transferase activity]
GO:0005515 [protein binding]
GO:0005524 [ATP binding]
GO:0005654 [nucleoplasm]
GO:0005829 [cytosol]
GO:0005886 [plasma membrane]
GO:0006281 [DNA repair]
GO:0006351 [transcription, DNA-templated]
GO:0006367 [transcription initiation from RNA polymerase II promoter]
GO:0006464 [cellular protein modification process]
GO:0006511 [ubiquitin-dependent protein catabolic process]
GO:0006513 [protein monoubiquitination]
GO:0006915 [apoptotic process]
GO:0007179 [transforming growth factor beta receptor signaling pathway]
GO:0010008 [endosome membrane]
GO:0010467 [gene expression]
GO:0016567 [protein ubiquitination]
GO:0030509 [BMP signaling pathway]
GO:0032480 [negative regulation of type I interferon production]
GO:0034138 [toll-like receptor 3 signaling pathway]
GO:0034142 [toll-like receptor 4 signaling pathway]
GO:0035666 [TRIF-dependent toll-like receptor signaling pathway]
GO:0043161 [proteasome-mediated ubiquitin-dependent protein catabolic process]
GO:0045087 [innate immune response]
GO:0051865 [protein autoubiquitination]
GO:0061418 [regulation of transcription from RNA polymerase II promoter in response to hypoxia]
GO:0061631 [ubiquitin conjugating enzyme activity]
GO:0070062 [extracellular exosome]
GO:0070936 [protein K48-linked ubiquitination]
GO:0070979 [protein K11-linked ubiquitination]
GO:0071456 [cellular response to hypoxia]
GO:1903955 [positive regulation of protein targeting to mitochondrion]
Show all
 148 aa
16.8 kDa 		No 0
UBE2D3-003
ENSP00000349722
ENST00000357194
P61077 [Direct mapping]
Ubiquitin-conjugating enzyme E2 D3
Show all
Enzymes
   ENZYME proteins
   Transferases
Predicted intracellular proteins
Protein evidence (Kim et al 2014)
Show all
GO:0000122 [negative regulation of transcription from RNA polymerase II promoter]
GO:0000209 [protein polyubiquitination]
GO:0002224 [toll-like receptor signaling pathway]
GO:0002756 [MyD88-independent toll-like receptor signaling pathway]
GO:0004842 [ubiquitin-protein transferase activity]
GO:0005515 [protein binding]
GO:0005524 [ATP binding]
GO:0005654 [nucleoplasm]
GO:0005829 [cytosol]
GO:0005886 [plasma membrane]
GO:0006281 [DNA repair]
GO:0006351 [transcription, DNA-templated]
GO:0006367 [transcription initiation from RNA polymerase II promoter]
GO:0006464 [cellular protein modification process]
GO:0006511 [ubiquitin-dependent protein catabolic process]
GO:0006513 [protein monoubiquitination]
GO:0006915 [apoptotic process]
GO:0007179 [transforming growth factor beta receptor signaling pathway]
GO:0010008 [endosome membrane]
GO:0010467 [gene expression]
GO:0016567 [protein ubiquitination]
GO:0030509 [BMP signaling pathway]
GO:0032480 [negative regulation of type I interferon production]
GO:0034138 [toll-like receptor 3 signaling pathway]
GO:0034142 [toll-like receptor 4 signaling pathway]
GO:0035666 [TRIF-dependent toll-like receptor signaling pathway]
GO:0043161 [proteasome-mediated ubiquitin-dependent protein catabolic process]
GO:0045087 [innate immune response]
GO:0051865 [protein autoubiquitination]
GO:0061418 [regulation of transcription from RNA polymerase II promoter in response to hypoxia]
GO:0061631 [ubiquitin conjugating enzyme activity]
GO:0070062 [extracellular exosome]
GO:0070936 [protein K48-linked ubiquitination]
GO:0070979 [protein K11-linked ubiquitination]
GO:0071456 [cellular response to hypoxia]
GO:1903955 [positive regulation of protein targeting to mitochondrion]
Show all
 149 aa
16.9 kDa 		No 0
UBE2D3-004
ENSP00000378280
ENST00000394801
P61077 [Direct mapping]
Ubiquitin-conjugating enzyme E2 D3
A0A024RDH2 [Target identity:100%; Query identity:100%]
Ubiquitin-conjugating enzyme E2D 3 (UBC4/5 homolog, yeast), isoform CRA_a
Show all
Enzymes
   ENZYME proteins
   Transferases
Predicted intracellular proteins
Protein evidence (Kim et al 2014)
Show all
GO:0000122 [negative regulation of transcription from RNA polymerase II promoter]
GO:0000209 [protein polyubiquitination]
GO:0002224 [toll-like receptor signaling pathway]
GO:0002756 [MyD88-independent toll-like receptor signaling pathway]
GO:0004842 [ubiquitin-protein transferase activity]
GO:0005515 [protein binding]
GO:0005524 [ATP binding]
GO:0005654 [nucleoplasm]
GO:0005829 [cytosol]
GO:0005886 [plasma membrane]
GO:0006281 [DNA repair]
GO:0006351 [transcription, DNA-templated]
GO:0006367 [transcription initiation from RNA polymerase II promoter]
GO:0006464 [cellular protein modification process]
GO:0006511 [ubiquitin-dependent protein catabolic process]
GO:0006513 [protein monoubiquitination]
GO:0006915 [apoptotic process]
GO:0007179 [transforming growth factor beta receptor signaling pathway]
GO:0010008 [endosome membrane]
GO:0010467 [gene expression]
GO:0016567 [protein ubiquitination]
GO:0030509 [BMP signaling pathway]
GO:0032480 [negative regulation of type I interferon production]
GO:0034138 [toll-like receptor 3 signaling pathway]
GO:0034142 [toll-like receptor 4 signaling pathway]
GO:0035666 [TRIF-dependent toll-like receptor signaling pathway]
GO:0043161 [proteasome-mediated ubiquitin-dependent protein catabolic process]
GO:0045087 [innate immune response]
GO:0051865 [protein autoubiquitination]
GO:0061418 [regulation of transcription from RNA polymerase II promoter in response to hypoxia]
GO:0061631 [ubiquitin conjugating enzyme activity]
GO:0070062 [extracellular exosome]
GO:0070936 [protein K48-linked ubiquitination]
GO:0070979 [protein K11-linked ubiquitination]
GO:0071456 [cellular response to hypoxia]
GO:1903955 [positive regulation of protein targeting to mitochondrion]
Show all
 147 aa
16.7 kDa 		No 0
UBE2D3-005
ENSP00000378282
ENST00000394803
P61077 [Direct mapping]
Ubiquitin-conjugating enzyme E2 D3
A0A024RDH2 [Target identity:100%; Query identity:100%]
Ubiquitin-conjugating enzyme E2D 3 (UBC4/5 homolog, yeast), isoform CRA_a
Show all
Enzymes
   ENZYME proteins
   Transferases
Predicted intracellular proteins
Protein evidence (Kim et al 2014)
Show all
GO:0000122 [negative regulation of transcription from RNA polymerase II promoter]
GO:0000209 [protein polyubiquitination]
GO:0002224 [toll-like receptor signaling pathway]
GO:0002756 [MyD88-independent toll-like receptor signaling pathway]
GO:0004842 [ubiquitin-protein transferase activity]
GO:0005515 [protein binding]
GO:0005524 [ATP binding]
GO:0005654 [nucleoplasm]
GO:0005829 [cytosol]
GO:0005886 [plasma membrane]
GO:0006281 [DNA repair]
GO:0006351 [transcription, DNA-templated]
GO:0006367 [transcription initiation from RNA polymerase II promoter]
GO:0006464 [cellular protein modification process]
GO:0006511 [ubiquitin-dependent protein catabolic process]
GO:0006513 [protein monoubiquitination]
GO:0006915 [apoptotic process]
GO:0007179 [transforming growth factor beta receptor signaling pathway]
GO:0010008 [endosome membrane]
GO:0010467 [gene expression]
GO:0016567 [protein ubiquitination]
GO:0030509 [BMP signaling pathway]
GO:0032480 [negative regulation of type I interferon production]
GO:0034138 [toll-like receptor 3 signaling pathway]
GO:0034142 [toll-like receptor 4 signaling pathway]
GO:0035666 [TRIF-dependent toll-like receptor signaling pathway]
GO:0043161 [proteasome-mediated ubiquitin-dependent protein catabolic process]
GO:0045087 [innate immune response]
GO:0051865 [protein autoubiquitination]
GO:0061418 [regulation of transcription from RNA polymerase II promoter in response to hypoxia]
GO:0061631 [ubiquitin conjugating enzyme activity]
GO:0070062 [extracellular exosome]
GO:0070936 [protein K48-linked ubiquitination]
GO:0070979 [protein K11-linked ubiquitination]
GO:0071456 [cellular response to hypoxia]
GO:1903955 [positive regulation of protein targeting to mitochondrion]
Show all
 147 aa
16.7 kDa 		No 0
UBE2D3-006
ENSP00000337208
ENST00000338145
P61077 [Direct mapping]
Ubiquitin-conjugating enzyme E2 D3
A0A024RDH2 [Target identity:100%; Query identity:100%]
Ubiquitin-conjugating enzyme E2D 3 (UBC4/5 homolog, yeast), isoform CRA_a
Show all
Enzymes
   ENZYME proteins
   Transferases
Predicted intracellular proteins
Protein evidence (Kim et al 2014)
Show all
GO:0000122 [negative regulation of transcription from RNA polymerase II promoter]
GO:0000209 [protein polyubiquitination]
GO:0002224 [toll-like receptor signaling pathway]
GO:0002756 [MyD88-independent toll-like receptor signaling pathway]
GO:0004842 [ubiquitin-protein transferase activity]
GO:0005515 [protein binding]
GO:0005524 [ATP binding]
GO:0005654 [nucleoplasm]
GO:0005829 [cytosol]
GO:0005886 [plasma membrane]
GO:0006281 [DNA repair]
GO:0006351 [transcription, DNA-templated]
GO:0006367 [transcription initiation from RNA polymerase II promoter]
GO:0006464 [cellular protein modification process]
GO:0006511 [ubiquitin-dependent protein catabolic process]
GO:0006513 [protein monoubiquitination]
GO:0006915 [apoptotic process]
GO:0007179 [transforming growth factor beta receptor signaling pathway]
GO:0010008 [endosome membrane]
GO:0010467 [gene expression]
GO:0016567 [protein ubiquitination]
GO:0030509 [BMP signaling pathway]
GO:0032480 [negative regulation of type I interferon production]
GO:0034138 [toll-like receptor 3 signaling pathway]
GO:0034142 [toll-like receptor 4 signaling pathway]
GO:0035666 [TRIF-dependent toll-like receptor signaling pathway]
GO:0043161 [proteasome-mediated ubiquitin-dependent protein catabolic process]
GO:0045087 [innate immune response]
GO:0051865 [protein autoubiquitination]
GO:0061418 [regulation of transcription from RNA polymerase II promoter in response to hypoxia]
GO:0061631 [ubiquitin conjugating enzyme activity]
GO:0070062 [extracellular exosome]
GO:0070936 [protein K48-linked ubiquitination]
GO:0070979 [protein K11-linked ubiquitination]
GO:0071456 [cellular response to hypoxia]
GO:1903955 [positive regulation of protein targeting to mitochondrion]
Show all
 147 aa
16.7 kDa 		No 0
UBE2D3-009
ENSP00000423487
ENST00000508238
D6RA11 [Direct mapping]
Ubiquitin-conjugating enzyme E2 D3
Show all
Predicted intracellular proteins
Show all
GO:0005524 [ATP binding]
GO:0008152 [metabolic process]
GO:0016874 [ligase activity]
Show all
 96 aa
10.7 kDa 		No 0
UBE2D3-010
ENSP00000421310
ENST00000508249
D6RGD0 [Direct mapping]
Ubiquitin-conjugating enzyme E2 D3
Show all
Predicted intracellular proteins
Show all
 49 aa
5.3 kDa 		No 0
UBE2D3-011
ENSP00000425762
ENST00000502690
D6RIZ3 [Direct mapping]
Ubiquitin-conjugating enzyme E2 D3
Show all
Predicted intracellular proteins
Show all
 78 aa
8.8 kDa 		No 0
UBE2D3-012
ENSP00000344069
ENST00000349311
P61077 [Direct mapping]
Ubiquitin-conjugating enzyme E2 D3
A0A024RDH2 [Target identity:100%; Query identity:100%]
Ubiquitin-conjugating enzyme E2D 3 (UBC4/5 homolog, yeast), isoform CRA_a
Show all
Enzymes
   ENZYME proteins
   Transferases
Predicted intracellular proteins
Show all
GO:0000122 [negative regulation of transcription from RNA polymerase II promoter]
GO:0000209 [protein polyubiquitination]
GO:0002224 [toll-like receptor signaling pathway]
GO:0002756 [MyD88-independent toll-like receptor signaling pathway]
GO:0004842 [ubiquitin-protein transferase activity]
GO:0005515 [protein binding]
GO:0005524 [ATP binding]
GO:0005654 [nucleoplasm]
GO:0005829 [cytosol]
GO:0005886 [plasma membrane]
GO:0006281 [DNA repair]
GO:0006351 [transcription, DNA-templated]
GO:0006367 [transcription initiation from RNA polymerase II promoter]
GO:0006464 [cellular protein modification process]
GO:0006511 [ubiquitin-dependent protein catabolic process]
GO:0006513 [protein monoubiquitination]
GO:0006915 [apoptotic process]
GO:0007179 [transforming growth factor beta receptor signaling pathway]
GO:0010008 [endosome membrane]
GO:0010467 [gene expression]
GO:0016567 [protein ubiquitination]
GO:0030509 [BMP signaling pathway]
GO:0032480 [negative regulation of type I interferon production]
GO:0034138 [toll-like receptor 3 signaling pathway]
GO:0034142 [toll-like receptor 4 signaling pathway]
GO:0035666 [TRIF-dependent toll-like receptor signaling pathway]
GO:0043161 [proteasome-mediated ubiquitin-dependent protein catabolic process]
GO:0045087 [innate immune response]
GO:0051865 [protein autoubiquitination]
GO:0061418 [regulation of transcription from RNA polymerase II promoter in response to hypoxia]
GO:0061631 [ubiquitin conjugating enzyme activity]
GO:0070062 [extracellular exosome]
GO:0070936 [protein K48-linked ubiquitination]
GO:0070979 [protein K11-linked ubiquitination]
GO:0071456 [cellular response to hypoxia]
GO:1903955 [positive regulation of protein targeting to mitochondrion]
Show all
 147 aa
16.7 kDa 		No 0
UBE2D3-013
ENSP00000318494
ENST00000321805
P61077 [Direct mapping]
Ubiquitin-conjugating enzyme E2 D3
A0A024RDH2 [Target identity:100%; Query identity:100%]
Ubiquitin-conjugating enzyme E2D 3 (UBC4/5 homolog, yeast), isoform CRA_a
Show all
Enzymes
   ENZYME proteins
   Transferases
Predicted intracellular proteins
Protein evidence (Kim et al 2014)
Show all
GO:0000122 [negative regulation of transcription from RNA polymerase II promoter]
GO:0000209 [protein polyubiquitination]
GO:0002224 [toll-like receptor signaling pathway]
GO:0002756 [MyD88-independent toll-like receptor signaling pathway]
GO:0004842 [ubiquitin-protein transferase activity]
GO:0005515 [protein binding]
GO:0005524 [ATP binding]
GO:0005654 [nucleoplasm]
GO:0005829 [cytosol]
GO:0005886 [plasma membrane]
GO:0006281 [DNA repair]
GO:0006351 [transcription, DNA-templated]
GO:0006367 [transcription initiation from RNA polymerase II promoter]
GO:0006464 [cellular protein modification process]
GO:0006511 [ubiquitin-dependent protein catabolic process]
GO:0006513 [protein monoubiquitination]
GO:0006915 [apoptotic process]
GO:0007179 [transforming growth factor beta receptor signaling pathway]
GO:0010008 [endosome membrane]
GO:0010467 [gene expression]
GO:0016567 [protein ubiquitination]
GO:0030509 [BMP signaling pathway]
GO:0032480 [negative regulation of type I interferon production]
GO:0034138 [toll-like receptor 3 signaling pathway]
GO:0034142 [toll-like receptor 4 signaling pathway]
GO:0035666 [TRIF-dependent toll-like receptor signaling pathway]
GO:0043161 [proteasome-mediated ubiquitin-dependent protein catabolic process]
GO:0045087 [innate immune response]
GO:0051865 [protein autoubiquitination]
GO:0061418 [regulation of transcription from RNA polymerase II promoter in response to hypoxia]
GO:0061631 [ubiquitin conjugating enzyme activity]
GO:0070062 [extracellular exosome]
GO:0070936 [protein K48-linked ubiquitination]
GO:0070979 [protein K11-linked ubiquitination]
GO:0071456 [cellular response to hypoxia]
GO:1903955 [positive regulation of protein targeting to mitochondrion]
Show all
 147 aa
16.7 kDa 		No 0
UBE2D3-014
ENSP00000337262
ENST00000350435
H9KV45 [Direct mapping]
Ubiquitin-conjugating enzyme E2 D3
Show all
Predicted intracellular proteins
Show all
GO:0005524 [ATP binding]
GO:0008152 [metabolic process]
GO:0016874 [ligase activity]
Show all
 141 aa
15.9 kDa 		No 0
UBE2D3-015
ENSP00000426586
ENST00000505207
D6RAH7 [Direct mapping]
Ubiquitin-conjugating enzyme E2 D3
Show all
Predicted intracellular proteins
Show all
GO:0005524 [ATP binding]
GO:0008152 [metabolic process]
GO:0016874 [ligase activity]
Show all
 118 aa
13.6 kDa 		No 0
UBE2D3-016
ENSP00000424359
ENST00000507845
D6RAH7 [Direct mapping]
Ubiquitin-conjugating enzyme E2 D3
Show all
Predicted intracellular proteins
Show all
GO:0005524 [ATP binding]
GO:0008152 [metabolic process]
GO:0016874 [ligase activity]
Show all
 118 aa
13.6 kDa 		No 0
UBE2D3-017
ENSP00000421904
ENST00000502404
D6RAH7 [Direct mapping]
Ubiquitin-conjugating enzyme E2 D3
Show all
Predicted intracellular proteins
Show all
GO:0005524 [ATP binding]
GO:0008152 [metabolic process]
GO:0016874 [ligase activity]
Show all
 118 aa
13.6 kDa 		No 0
UBE2D3-018
ENSP00000424710
ENST00000508476
D6RAW0 [Direct mapping]
Ubiquitin-conjugating enzyme E2 D3
Show all
Predicted intracellular proteins
Show all
GO:0005524 [ATP binding]
GO:0008152 [metabolic process]
GO:0016874 [ligase activity]
Show all
 72 aa
8.2 kDa 		No 0
UBE2D3-019
ENSP00000426620
ENST00000504211
D6RAH7 [Direct mapping]
Ubiquitin-conjugating enzyme E2 D3
Show all
Predicted intracellular proteins
Show all
GO:0005524 [ATP binding]
GO:0008152 [metabolic process]
GO:0016874 [ligase activity]
Show all
 118 aa
13.6 kDa 		No 0
UBE2D3-201
ENSP00000378283
ENST00000394804
P61077 [Direct mapping]
Ubiquitin-conjugating enzyme E2 D3
A0A024RDH2 [Target identity:100%; Query identity:100%]
Ubiquitin-conjugating enzyme E2D 3 (UBC4/5 homolog, yeast), isoform CRA_a
Show all
Enzymes
   ENZYME proteins
   Transferases
Predicted intracellular proteins
Protein evidence (Kim et al 2014)
Show all
GO:0000122 [negative regulation of transcription from RNA polymerase II promoter]
GO:0000209 [protein polyubiquitination]
GO:0002224 [toll-like receptor signaling pathway]
GO:0002756 [MyD88-independent toll-like receptor signaling pathway]
GO:0004842 [ubiquitin-protein transferase activity]
GO:0005515 [protein binding]
GO:0005524 [ATP binding]
GO:0005654 [nucleoplasm]
GO:0005829 [cytosol]
GO:0005886 [plasma membrane]
GO:0006281 [DNA repair]
GO:0006351 [transcription, DNA-templated]
GO:0006367 [transcription initiation from RNA polymerase II promoter]
GO:0006464 [cellular protein modification process]
GO:0006511 [ubiquitin-dependent protein catabolic process]
GO:0006513 [protein monoubiquitination]
GO:0006915 [apoptotic process]
GO:0007179 [transforming growth factor beta receptor signaling pathway]
GO:0010008 [endosome membrane]
GO:0010467 [gene expression]
GO:0016567 [protein ubiquitination]
GO:0030509 [BMP signaling pathway]
GO:0032480 [negative regulation of type I interferon production]
GO:0034138 [toll-like receptor 3 signaling pathway]
GO:0034142 [toll-like receptor 4 signaling pathway]
GO:0035666 [TRIF-dependent toll-like receptor signaling pathway]
GO:0043161 [proteasome-mediated ubiquitin-dependent protein catabolic process]
GO:0045087 [innate immune response]
GO:0051865 [protein autoubiquitination]
GO:0061418 [regulation of transcription from RNA polymerase II promoter in response to hypoxia]
GO:0061631 [ubiquitin conjugating enzyme activity]
GO:0070062 [extracellular exosome]
GO:0070936 [protein K48-linked ubiquitination]
GO:0070979 [protein K11-linked ubiquitination]
GO:0071456 [cellular response to hypoxia]
GO:1903955 [positive regulation of protein targeting to mitochondrion]
Show all
 147 aa
16.7 kDa 		No 0
UBE2D3-202
ENSP00000481600
ENST00000618836
A0A087WY85 [Direct mapping]
Ubiquitin-conjugating enzyme E2 D3
Show all
Predicted intracellular proteins
Show all
GO:0005524 [ATP binding]
GO:0008152 [metabolic process]
GO:0016874 [ligase activity]
Show all
 148 aa
16.8 kDa 		No 0

Contact

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The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.