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MAPK10

GENERAL INFORMATION

Gene name

 MAPK10

Gene description

 Mitogen-activated protein kinase 10

Protein class

 Disease related genes
Enzymes
Potential drug targets
Predicted intracellular proteins
RAS pathway related proteins

Predicted localization

 Intracellular

Number of transcripts

 19
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HUMAN PROTEIN ATLAS INFORMATION

RNA category
TCGA (cancer tissue):Mixed
HPA (cell line):Cell line enriched (AF22)
HPA (normal tissue):Tissue enhanced (cerebral cortex)

Protein evidence

 Evidence at protein level

Protein expression
normal tissue

 Neuronal expression in cerebral cortex.

ANTIBODY IHC RELIABILITY

Data reliability
description

 Antibody staining mainly not consistent with RNA expression data.

Reliability score

 Approved based on 1 antibody.
CAB022625
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PROGNOSTIC SUMMARY
Prognostic marker in renal cancer (favourable) and urothelial cancer (favourable).
Renal cancer p<0.001
Urothelial cancer p<0.001
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RNA EXPRESSION OVERVIEW
TCGA dataset
RNA cancer category: Mixed

PROTEIN EXPRESSION
Colorectal cancer
Breast cancer
Prostate cancer
Lung cancer
Liver cancer

STAINING SUMMARY
CAB022625

GENE INFORMATION

Gene name

 MAPK10 (HGNC Symbol)

Synonyms

 JNK3, p493F12, p54bSAPK, PRKM10

Description

 Mitogen-activated protein kinase 10 (HGNC Symbol)

Entrez gene summary

 The protein encoded by this gene is a member of the MAP kinase family. MAP kinases act as an integration point for multiple biochemical signals, and are involved in a wide variety of cellular processes such as proliferation, differentiation, transcription regulation and development. This protein is a neuronal-specific form of c-Jun N-terminal kinases (JNKs). Through its phosphorylation and nuclear localization, this kinase plays regulatory roles in the signaling pathways during neuronal apoptosis. Beta-arrestin 2, a receptor-regulated MAP kinase scaffold protein, is found to interact with, and stimulate the phosphorylation of this kinase by MAP kinase kinase 4 (MKK4). Cyclin-dependent kianse 5 can phosphorylate, and inhibit the activity of this kinase, which may be important in preventing neuronal apoptosis. Four alternatively spliced transcript variants encoding distinct isoforms have been reported. [provided by RefSeq, Jul 2008]

Chromosome

 4

Cytoband

 q21.3

Chromosome location (bp)

 86015123 - 86594131

Protein evidence

 Evidence at protein level (all genes)

Ensembl

 ENSG00000109339 (version 83.38)

Entrez gene

 5602

UniProt

 P53779 (UniProt - Evidence at protein level)

neXtProt

 NX_P53779

Antibodypedia

 MAPK10 antibodies

PROTEIN BROWSER
«
MAPK10-001
MAPK10-002
MAPK10-004
MAPK10-005
MAPK10-012
MAPK10-014
MAPK10-015
MAPK10-017
MAPK10-018
MAPK10-020
MAPK10-021
MAPK10-025
MAPK10-026
MAPK10-027
MAPK10-028
MAPK10-029
MAPK10-030
MAPK10-201
MAPK10-202
»

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)
MAPK10-001
ENSP00000378598
ENST00000395169
P53779 [Direct mapping]
Mitogen-activated protein kinase 10
Show all
Enzymes
   ENZYME proteins
   Transferases
   Kinases
   CMGC Ser/Thr protein kinases
   MEMSAT-SVM predicted membrane proteins
Predicted intracellular proteins
RAS pathway related proteins
Disease related genes
Potential drug targets
Protein evidence (Kim et al 2014)
Show all
GO:0000187 [activation of MAPK activity]
GO:0002224 [toll-like receptor signaling pathway]
GO:0002755 [MyD88-dependent toll-like receptor signaling pathway]
GO:0002756 [MyD88-independent toll-like receptor signaling pathway]
GO:0004672 [protein kinase activity]
GO:0004705 [JUN kinase activity]
GO:0004707 [MAP kinase activity]
GO:0004708 [MAP kinase kinase activity]
GO:0005515 [protein binding]
GO:0005524 [ATP binding]
GO:0005654 [nucleoplasm]
GO:0005737 [cytoplasm]
GO:0005739 [mitochondrion]
GO:0005829 [cytosol]
GO:0005886 [plasma membrane]
GO:0006468 [protein phosphorylation]
GO:0007165 [signal transduction]
GO:0007254 [JNK cascade]
GO:0009416 [response to light stimulus]
GO:0034134 [toll-like receptor 2 signaling pathway]
GO:0034138 [toll-like receptor 3 signaling pathway]
GO:0034142 [toll-like receptor 4 signaling pathway]
GO:0034146 [toll-like receptor 5 signaling pathway]
GO:0034162 [toll-like receptor 9 signaling pathway]
GO:0034166 [toll-like receptor 10 signaling pathway]
GO:0035666 [TRIF-dependent toll-like receptor signaling pathway]
GO:0038095 [Fc-epsilon receptor signaling pathway]
GO:0038123 [toll-like receptor TLR1:TLR2 signaling pathway]
GO:0038124 [toll-like receptor TLR6:TLR2 signaling pathway]
GO:0042752 [regulation of circadian rhythm]
GO:0045087 [innate immune response]
GO:0048511 [rhythmic process]
GO:0051090 [regulation of sequence-specific DNA binding transcription factor activity]
GO:0051403 [stress-activated MAPK cascade]
Show all
 426 aa
48.1 kDa 		No 0
MAPK10-002
ENSP00000378595
ENST00000395166
P53779 [Direct mapping]
Mitogen-activated protein kinase 10
Show all
Enzymes
   ENZYME proteins
   Transferases
   Kinases
   CMGC Ser/Thr protein kinases
   MEMSAT-SVM predicted membrane proteins
Predicted intracellular proteins
RAS pathway related proteins
Disease related genes
Potential drug targets
Show all
GO:0000187 [activation of MAPK activity]
GO:0002224 [toll-like receptor signaling pathway]
GO:0002755 [MyD88-dependent toll-like receptor signaling pathway]
GO:0002756 [MyD88-independent toll-like receptor signaling pathway]
GO:0004672 [protein kinase activity]
GO:0004705 [JUN kinase activity]
GO:0004707 [MAP kinase activity]
GO:0004708 [MAP kinase kinase activity]
GO:0005515 [protein binding]
GO:0005524 [ATP binding]
GO:0005654 [nucleoplasm]
GO:0005737 [cytoplasm]
GO:0005739 [mitochondrion]
GO:0005829 [cytosol]
GO:0005886 [plasma membrane]
GO:0006468 [protein phosphorylation]
GO:0007165 [signal transduction]
GO:0007254 [JNK cascade]
GO:0009416 [response to light stimulus]
GO:0034134 [toll-like receptor 2 signaling pathway]
GO:0034138 [toll-like receptor 3 signaling pathway]
GO:0034142 [toll-like receptor 4 signaling pathway]
GO:0034146 [toll-like receptor 5 signaling pathway]
GO:0034162 [toll-like receptor 9 signaling pathway]
GO:0034166 [toll-like receptor 10 signaling pathway]
GO:0035666 [TRIF-dependent toll-like receptor signaling pathway]
GO:0038095 [Fc-epsilon receptor signaling pathway]
GO:0038123 [toll-like receptor TLR1:TLR2 signaling pathway]
GO:0038124 [toll-like receptor TLR6:TLR2 signaling pathway]
GO:0042752 [regulation of circadian rhythm]
GO:0045087 [innate immune response]
GO:0048511 [rhythmic process]
GO:0051090 [regulation of sequence-specific DNA binding transcription factor activity]
GO:0051403 [stress-activated MAPK cascade]
Show all
 426 aa
48.1 kDa 		No 0
MAPK10-004
ENSP00000378589
ENST00000395160
P53779 [Direct mapping]
Mitogen-activated protein kinase 10
Show all
Enzymes
   ENZYME proteins
   Transferases
   Kinases
   CMGC Ser/Thr protein kinases
   MEMSAT-SVM predicted membrane proteins
Predicted intracellular proteins
RAS pathway related proteins
Disease related genes
Potential drug targets
Protein evidence (Kim et al 2014)
Show all
GO:0000187 [activation of MAPK activity]
GO:0002224 [toll-like receptor signaling pathway]
GO:0002755 [MyD88-dependent toll-like receptor signaling pathway]
GO:0002756 [MyD88-independent toll-like receptor signaling pathway]
GO:0004672 [protein kinase activity]
GO:0004705 [JUN kinase activity]
GO:0004708 [MAP kinase kinase activity]
GO:0005515 [protein binding]
GO:0005524 [ATP binding]
GO:0005654 [nucleoplasm]
GO:0005737 [cytoplasm]
GO:0005739 [mitochondrion]
GO:0005829 [cytosol]
GO:0005886 [plasma membrane]
GO:0006468 [protein phosphorylation]
GO:0007165 [signal transduction]
GO:0007254 [JNK cascade]
GO:0009416 [response to light stimulus]
GO:0034134 [toll-like receptor 2 signaling pathway]
GO:0034138 [toll-like receptor 3 signaling pathway]
GO:0034142 [toll-like receptor 4 signaling pathway]
GO:0034146 [toll-like receptor 5 signaling pathway]
GO:0034162 [toll-like receptor 9 signaling pathway]
GO:0034166 [toll-like receptor 10 signaling pathway]
GO:0035666 [TRIF-dependent toll-like receptor signaling pathway]
GO:0038095 [Fc-epsilon receptor signaling pathway]
GO:0038123 [toll-like receptor TLR1:TLR2 signaling pathway]
GO:0038124 [toll-like receptor TLR6:TLR2 signaling pathway]
GO:0042752 [regulation of circadian rhythm]
GO:0045087 [innate immune response]
GO:0048511 [rhythmic process]
GO:0051090 [regulation of sequence-specific DNA binding transcription factor activity]
GO:0051403 [stress-activated MAPK cascade]
Show all
 277 aa
31.9 kDa 		No 0
MAPK10-005
ENSP00000355297
ENST00000361569
P53779 [Direct mapping]
Mitogen-activated protein kinase 10
Show all
Enzymes
   ENZYME proteins
   Transferases
   Kinases
   CMGC Ser/Thr protein kinases
   MEMSAT-SVM predicted membrane proteins
Predicted intracellular proteins
RAS pathway related proteins
Disease related genes
Potential drug targets
Protein evidence (Kim et al 2014)
Show all
GO:0000187 [activation of MAPK activity]
GO:0002224 [toll-like receptor signaling pathway]
GO:0002755 [MyD88-dependent toll-like receptor signaling pathway]
GO:0002756 [MyD88-independent toll-like receptor signaling pathway]
GO:0004672 [protein kinase activity]
GO:0004705 [JUN kinase activity]
GO:0004707 [MAP kinase activity]
GO:0004708 [MAP kinase kinase activity]
GO:0005515 [protein binding]
GO:0005524 [ATP binding]
GO:0005654 [nucleoplasm]
GO:0005737 [cytoplasm]
GO:0005739 [mitochondrion]
GO:0005829 [cytosol]
GO:0005886 [plasma membrane]
GO:0006468 [protein phosphorylation]
GO:0007165 [signal transduction]
GO:0007254 [JNK cascade]
GO:0009416 [response to light stimulus]
GO:0034134 [toll-like receptor 2 signaling pathway]
GO:0034138 [toll-like receptor 3 signaling pathway]
GO:0034142 [toll-like receptor 4 signaling pathway]
GO:0034146 [toll-like receptor 5 signaling pathway]
GO:0034162 [toll-like receptor 9 signaling pathway]
GO:0034166 [toll-like receptor 10 signaling pathway]
GO:0035666 [TRIF-dependent toll-like receptor signaling pathway]
GO:0038095 [Fc-epsilon receptor signaling pathway]
GO:0038123 [toll-like receptor TLR1:TLR2 signaling pathway]
GO:0038124 [toll-like receptor TLR6:TLR2 signaling pathway]
GO:0042752 [regulation of circadian rhythm]
GO:0045087 [innate immune response]
GO:0048511 [rhythmic process]
GO:0051090 [regulation of sequence-specific DNA binding transcription factor activity]
GO:0051403 [stress-activated MAPK cascade]
Show all
 422 aa
48.6 kDa 		No 0
MAPK10-012
ENSP00000352157
ENST00000359221
P53779 [Direct mapping]
Mitogen-activated protein kinase 10
Show all
Enzymes
   ENZYME proteins
   Transferases
   Kinases
   CMGC Ser/Thr protein kinases
   MEMSAT-SVM predicted membrane proteins
Predicted intracellular proteins
RAS pathway related proteins
Disease related genes
Potential drug targets
Protein evidence (Kim et al 2014)
Show all
GO:0000187 [activation of MAPK activity]
GO:0002224 [toll-like receptor signaling pathway]
GO:0002755 [MyD88-dependent toll-like receptor signaling pathway]
GO:0002756 [MyD88-independent toll-like receptor signaling pathway]
GO:0004672 [protein kinase activity]
GO:0004705 [JUN kinase activity]
GO:0004707 [MAP kinase activity]
GO:0004708 [MAP kinase kinase activity]
GO:0005515 [protein binding]
GO:0005524 [ATP binding]
GO:0005654 [nucleoplasm]
GO:0005737 [cytoplasm]
GO:0005739 [mitochondrion]
GO:0005829 [cytosol]
GO:0005886 [plasma membrane]
GO:0006468 [protein phosphorylation]
GO:0007165 [signal transduction]
GO:0007254 [JNK cascade]
GO:0009416 [response to light stimulus]
GO:0034134 [toll-like receptor 2 signaling pathway]
GO:0034138 [toll-like receptor 3 signaling pathway]
GO:0034142 [toll-like receptor 4 signaling pathway]
GO:0034146 [toll-like receptor 5 signaling pathway]
GO:0034162 [toll-like receptor 9 signaling pathway]
GO:0034166 [toll-like receptor 10 signaling pathway]
GO:0035666 [TRIF-dependent toll-like receptor signaling pathway]
GO:0038095 [Fc-epsilon receptor signaling pathway]
GO:0038123 [toll-like receptor TLR1:TLR2 signaling pathway]
GO:0038124 [toll-like receptor TLR6:TLR2 signaling pathway]
GO:0042752 [regulation of circadian rhythm]
GO:0045087 [innate immune response]
GO:0048511 [rhythmic process]
GO:0051090 [regulation of sequence-specific DNA binding transcription factor activity]
GO:0051403 [stress-activated MAPK cascade]
GO:0097481 [neuronal postsynaptic density]
Show all
 464 aa
52.6 kDa 		No 0
MAPK10-014
ENSP00000378586
ENST00000395157
A8MWW6 [Direct mapping]
MAPK10 protein; Mitogen-activated protein kinase 10
Show all
   MEMSAT-SVM predicted membrane proteins
Predicted intracellular proteins
RAS pathway related proteins
Show all
GO:0000165 [MAPK cascade]
GO:0004672 [protein kinase activity]
GO:0004707 [MAP kinase activity]
GO:0005524 [ATP binding]
GO:0005622 [intracellular]
GO:0006468 [protein phosphorylation]
Show all
 319 aa
36 kDa 		No 0
MAPK10-015
ENSP00000424154
ENST00000515400
H0Y9H3 [Direct mapping]
Mitogen-activated protein kinase 10
Show all
   MEMSAT-SVM predicted membrane proteins
   SPOCTOPUS predicted membrane proteins
Predicted intracellular proteins
RAS pathway related proteins
Show all
GO:0000165 [MAPK cascade]
GO:0004672 [protein kinase activity]
GO:0004707 [MAP kinase activity]
GO:0005524 [ATP binding]
GO:0005622 [intracellular]
GO:0006468 [protein phosphorylation]
Show all
 335 aa
38.4 kDa 		No 0
MAPK10-017
ENSP00000420987
ENST00000513186
D6RDG1 [Direct mapping]
Mitogen-activated protein kinase 10
Show all
Predicted intracellular proteins
RAS pathway related proteins
Show all
 48 aa
5.6 kDa 		No 0
MAPK10-018
ENSP00000423918
ENST00000502302
D6RC26 [Direct mapping]
Mitogen-activated protein kinase 10
Show all
Predicted intracellular proteins
RAS pathway related proteins
Show all
 33 aa
3.8 kDa 		No 0
MAPK10-020
ENSP00000421409
ENST00000503911
D6RFX8 [Direct mapping]
Mitogen-activated protein kinase 10
Show all
Predicted intracellular proteins
RAS pathway related proteins
Show all
 51 aa
6 kDa 		No 0
MAPK10-021
ENSP00000421762
ENST00000511328
D6RAJ0 [Direct mapping]
Mitogen-activated protein kinase 10
Show all
Predicted intracellular proteins
RAS pathway related proteins
Show all
GO:0004672 [protein kinase activity]
GO:0005524 [ATP binding]
GO:0006468 [protein phosphorylation]
Show all
 117 aa
13.4 kDa 		No 0
MAPK10-025
ENSP00000425654
ENST00000512689
D6RJF9 [Direct mapping]
Mitogen-activated protein kinase 10
Show all
Predicted intracellular proteins
RAS pathway related proteins
Show all
 52 aa
5.7 kDa 		No 0
MAPK10-026
ENSP00000421359
ENST00000506773
D6RFZ7 [Direct mapping]
Mitogen-activated protein kinase 10
Show all
Predicted intracellular proteins
RAS pathway related proteins
Show all
 91 aa
10.2 kDa 		No 0
MAPK10-027
ENSP00000424755
ENST00000512017
D6RAU3 [Direct mapping]
Mitogen-activated protein kinase 10
Show all
Predicted intracellular proteins
RAS pathway related proteins
Show all
GO:0004672 [protein kinase activity]
GO:0005524 [ATP binding]
GO:0006468 [protein phosphorylation]
Show all
 141 aa
16.2 kDa 		No 0
MAPK10-028
ENSP00000422985
ENST00000512564
D6R9C1 [Direct mapping]
Mitogen-activated protein kinase 10
Show all
Predicted intracellular proteins
RAS pathway related proteins
Show all
GO:0004672 [protein kinase activity]
GO:0005524 [ATP binding]
GO:0006468 [protein phosphorylation]
Show all
 84 aa
9.5 kDa 		No 0
MAPK10-029
ENSP00000422277
ENST00000511167
D6RCB1 [Direct mapping]
Mitogen-activated protein kinase 10
Show all
Predicted intracellular proteins
RAS pathway related proteins
Show all
GO:0004672 [protein kinase activity]
GO:0005524 [ATP binding]
GO:0006468 [protein phosphorylation]
Show all
 121 aa
13.8 kDa 		No 0
MAPK10-030
ENSP00000424128
ENST00000509464
D6RBH2 [Direct mapping]
Mitogen-activated protein kinase 10
Show all
Predicted intracellular proteins
RAS pathway related proteins
Show all
GO:0004672 [protein kinase activity]
GO:0005524 [ATP binding]
GO:0006468 [protein phosphorylation]
Show all
 74 aa
8.3 kDa 		No 0
MAPK10-201
ENSP00000378590
ENST00000395161
Q499Y8 [Direct mapping]
MAPK10 protein; Mitogen-activated protein kinase 10
Show all
   MEMSAT3 predicted membrane proteins
   MEMSAT-SVM predicted membrane proteins
   SPOCTOPUS predicted membrane proteins
Predicted intracellular proteins
RAS pathway related proteins
Show all
GO:0000165 [MAPK cascade]
GO:0004672 [protein kinase activity]
GO:0004707 [MAP kinase activity]
GO:0005515 [protein binding]
GO:0005524 [ATP binding]
GO:0005622 [intracellular]
GO:0006468 [protein phosphorylation]
Show all
 319 aa
35.7 kDa 		No 0
MAPK10-202
ENSP00000414469
ENST00000449047
Q499Y8 [Direct mapping]
MAPK10 protein; Mitogen-activated protein kinase 10
Show all
   MEMSAT3 predicted membrane proteins
   MEMSAT-SVM predicted membrane proteins
   SPOCTOPUS predicted membrane proteins
Predicted intracellular proteins
RAS pathway related proteins
Show all
GO:0000165 [MAPK cascade]
GO:0004672 [protein kinase activity]
GO:0004707 [MAP kinase activity]
GO:0005515 [protein binding]
GO:0005524 [ATP binding]
GO:0005622 [intracellular]
GO:0006468 [protein phosphorylation]
Show all
 319 aa
35.7 kDa 		No 0

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The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.