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ELF2

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GENERAL INFORMATION

Gene name

 ELF2

Gene description

 E74-like factor 2 (ets domain transcription factor)

Protein class

 Predicted intracellular proteins
Transcription factors

Predicted localization

 Intracellular

Number of transcripts

 7
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HUMAN PROTEIN ATLAS INFORMATION

Summary

 Mainly localized to the nucleoplasm. In addition localized to the nuclear bodies.

RNA cell category

 Expressed in all

Protein evidence

 Evidence at protein level

Main location

 Localized to the Nucleoplasm (supported)

Additional location

 In addition localized to the Nuclear bodies (supported)

Mouse

 Localized to the Nucleoplasm in mouse cells.

DATA RELIABILITY

Reliability score

 Supported based on 2 antibodies.
HPA006057 , HPA071166
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ASSAYS
RNA expression
Human cells
Mouse cells

RNA EXPRESSION OVERVIEW
RNA cell line category: Expressed in all
Organ
Origin
Category
Expression
Alphabetical
Cell lines sorted after organ of phenotypic resemblance.

HUMAN CELLS

Summary

 Mainly localized to the nucleoplasm. In addition localized to the nuclear bodies.

Main location

 Nucleoplasm (supported)

Additional location

 Nuclear bodies (supported)

 

 

 
Toggle channels
Low
High
G1
S
G2
M
N/A

Thumbnail

Antibody

Cell line

Location

Single-cell variation

Cell cycle dependent variation
HPA006057 A-431 Nucleoplasm
Nuclear bodies
Cytosol
HPA006057 U-2 OS Nucleoplasm
Nuclear bodies
Cytosol
HPA006057 U-251 MG Nucleoplasm
Nuclear bodies
Cytosol
HPA071166 RT4 Nucleoplasm
HPA071166 U-2 OS Nucleoplasm

MOUSE CELLS

Main location

 Nucleoplasm

Mouse gene

 ENSMUSG00000037174 (version 83)

 

 

 
Toggle channels
Low
High
G1
S
G2
M
N/A

Thumbnail

Antibody

Cell line

Location
HPA006057 NIH 3T3 Nucleoplasm

GENE INFORMATION

Gene name

 ELF2 (HGNC Symbol)

Synonyms

 EU32, NERF, NERF-1A, NERF-1B, NERF-2

Description

 E74-like factor 2 (ets domain transcription factor) (HGNC Symbol)

Entrez gene summary

Chromosome

 4

Cytoband

 q31.1

Chromosome location (bp)

 139028112 - 139177218

Protein evidence

 Evidence at protein level (all genes)

Ensembl

 ENSG00000109381 (version 83.38)

Entrez gene

 1998

UniProt

 Q15723 (UniProt - Evidence at protein level)

neXtProt

 NX_Q15723

Antibodypedia

 ELF2 antibodies

PROTEIN BROWSER
ELF2-001
ELF2-002
ELF2-006
ELF2-008
ELF2-009
ELF2-201
ELF2-202

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)
ELF2-001
ENSP00000377782
ENST00000394235
Q15723 [Direct mapping]
ETS-related transcription factor Elf-2
Show all
Predicted intracellular proteins
Transcription factors
   Helix-turn-helix domains
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000981 [RNA polymerase II transcription factor activity, sequence-specific DNA binding]
GO:0003700 [transcription factor activity, sequence-specific DNA binding]
GO:0005515 [protein binding]
GO:0005634 [nucleus]
GO:0005654 [nucleoplasm]
GO:0005737 [cytoplasm]
GO:0006351 [transcription, DNA-templated]
GO:0006355 [regulation of transcription, DNA-templated]
GO:0006357 [regulation of transcription from RNA polymerase II promoter]
GO:0030154 [cell differentiation]
GO:0043565 [sequence-specific DNA binding]
GO:0045892 [negative regulation of transcription, DNA-templated]
GO:0045893 [positive regulation of transcription, DNA-templated]
Show all
 581 aa
62.7 kDa 		No 0
ELF2-002
ENSP00000351458
ENST00000358635
Q15723 [Direct mapping]
ETS-related transcription factor Elf-2
Show all
Predicted intracellular proteins
Transcription factors
   Helix-turn-helix domains
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000981 [RNA polymerase II transcription factor activity, sequence-specific DNA binding]
GO:0003700 [transcription factor activity, sequence-specific DNA binding]
GO:0005515 [protein binding]
GO:0005634 [nucleus]
GO:0005654 [nucleoplasm]
GO:0005737 [cytoplasm]
GO:0006351 [transcription, DNA-templated]
GO:0006355 [regulation of transcription, DNA-templated]
GO:0006357 [regulation of transcription from RNA polymerase II promoter]
GO:0030154 [cell differentiation]
GO:0043565 [sequence-specific DNA binding]
GO:0045892 [negative regulation of transcription, DNA-templated]
GO:0045893 [positive regulation of transcription, DNA-templated]
Show all
 533 aa
57.4 kDa 		No 0
ELF2-006
ENSP00000426997
ENST00000510408
Q15723 [Direct mapping]
ETS-related transcription factor Elf-2
B7Z720 [Target identity:100%; Query identity:100%]
E74-like factor 2 (Ets domain transcription factor), isoform CRA_b; cDNA FLJ53930, highly similar to ETS-related transcription factor Elf-2; cDNA, FLJ79354, highly similar to ETS-related transcription factor Elf-2
Show all
Predicted intracellular proteins
Transcription factors
   Helix-turn-helix domains
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000981 [RNA polymerase II transcription factor activity, sequence-specific DNA binding]
GO:0003700 [transcription factor activity, sequence-specific DNA binding]
GO:0005515 [protein binding]
GO:0005634 [nucleus]
GO:0005654 [nucleoplasm]
GO:0005737 [cytoplasm]
GO:0006351 [transcription, DNA-templated]
GO:0006355 [regulation of transcription, DNA-templated]
GO:0006357 [regulation of transcription from RNA polymerase II promoter]
GO:0030154 [cell differentiation]
GO:0043565 [sequence-specific DNA binding]
GO:0045892 [negative regulation of transcription, DNA-templated]
GO:0045893 [positive regulation of transcription, DNA-templated]
Show all
 521 aa
56.1 kDa 		No 0
ELF2-008
ENSP00000426087
ENST00000512627
D6RHI1 [Direct mapping]
ETS-related transcription factor Elf-2
Show all
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000981 [RNA polymerase II transcription factor activity, sequence-specific DNA binding]
GO:0003700 [transcription factor activity, sequence-specific DNA binding]
GO:0005634 [nucleus]
GO:0006355 [regulation of transcription, DNA-templated]
GO:0006357 [regulation of transcription from RNA polymerase II promoter]
GO:0030154 [cell differentiation]
GO:0043565 [sequence-specific DNA binding]
Show all
 192 aa
22 kDa 		No 0
ELF2-009
ENSP00000397796
ENST00000420916
D6R9B1 [Direct mapping]
ETS-related transcription factor Elf-2
Show all
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000981 [RNA polymerase II transcription factor activity, sequence-specific DNA binding]
GO:0003700 [transcription factor activity, sequence-specific DNA binding]
GO:0005634 [nucleus]
GO:0006355 [regulation of transcription, DNA-templated]
GO:0006357 [regulation of transcription from RNA polymerase II promoter]
GO:0030154 [cell differentiation]
GO:0043565 [sequence-specific DNA binding]
Show all
 245 aa
27.6 kDa 		No 0
ELF2-201
ENSP00000368867
ENST00000379549
Q15723 [Direct mapping]
ETS-related transcription factor Elf-2
Show all
Predicted intracellular proteins
Transcription factors
   Helix-turn-helix domains
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000981 [RNA polymerase II transcription factor activity, sequence-specific DNA binding]
GO:0003700 [transcription factor activity, sequence-specific DNA binding]
GO:0005515 [protein binding]
GO:0005634 [nucleus]
GO:0005654 [nucleoplasm]
GO:0005737 [cytoplasm]
GO:0006351 [transcription, DNA-templated]
GO:0006355 [regulation of transcription, DNA-templated]
GO:0006357 [regulation of transcription from RNA polymerase II promoter]
GO:0030154 [cell differentiation]
GO:0043565 [sequence-specific DNA binding]
GO:0045892 [negative regulation of transcription, DNA-templated]
GO:0045893 [positive regulation of transcription, DNA-templated]
Show all
 504 aa
54.3 kDa 		No 0
ELF2-202
ENSP00000368868
ENST00000379550
Q15723 [Direct mapping]
ETS-related transcription factor Elf-2
Show all
Predicted intracellular proteins
Transcription factors
   Helix-turn-helix domains
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000981 [RNA polymerase II transcription factor activity, sequence-specific DNA binding]
GO:0003700 [transcription factor activity, sequence-specific DNA binding]
GO:0005515 [protein binding]
GO:0005634 [nucleus]
GO:0005654 [nucleoplasm]
GO:0005737 [cytoplasm]
GO:0006351 [transcription, DNA-templated]
GO:0006355 [regulation of transcription, DNA-templated]
GO:0006357 [regulation of transcription from RNA polymerase II promoter]
GO:0030154 [cell differentiation]
GO:0043565 [sequence-specific DNA binding]
GO:0045892 [negative regulation of transcription, DNA-templated]
GO:0045893 [positive regulation of transcription, DNA-templated]
Show all
 593 aa
64 kDa 		No 0

Contact

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.