Expression of INPP4B in cancer - Summary - The Human Protein Atlas

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INPP4B

TISSUE

CELL

PATHOLOGY

PATHOLOGY ATLAS

GENE/PROTEIN

Antibody validation

Dictionary


Level of antibody staining/expression
	High Medium Low Not detected

GENERAL INFORMATION
Gene name	INPP4B
Gene description	Inositol polyphosphate-4-phosphatase type II B
Protein class	Enzymes Predicted intracellular proteins Predicted membrane proteins
Predicted localization	Intracellular,Membrane
Number of transcripts	12
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HUMAN PROTEIN ATLAS INFORMATION

RNA category

TCGA (cancer tissue):	Mixed
HPA (cell line):	Cell line enhanced (CAPAN-2)
HPA (normal tissue):	Mixed

Protein evidence

Evidence at protein level

Protein expression
normal tissue

Cytoplasmic expression of varying intensity in several tissues.

ANTIBODY IHC RELIABILITY
Data reliability description	Antibody staining mainly consistent with RNA expression data.
Reliability score	Approved based on 2 antibodies. HPA037681 , HPA037682
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PROGNOSTIC SUMMARY
Prognostic marker in pancreatic cancer (unfavourable).
Pancreatic cancer p<0.001 Show all

RNA EXPRESSION OVERVIEW
TCGA dataset RNA cancer category: Mixed

PROTEIN EXPRESSION

Colorectal cancer

Prostate cancer

STAINING SUMMARY

HPA037681	HPA037682

GENE INFORMATION
Gene name	INPP4B
Synonyms
Description	Inositol polyphosphate-4-phosphatase type II B (HGNC Symbol)
Entrez gene summary	INPP4B encodes the inositol polyphosphate 4-phosphatase type II, one of the enzymes involved in phosphatidylinositol signaling pathways. This enzyme removes the phosphate group at position 4 of the inositol ring from inositol 3,4-bisphosphate. There is limited data to suggest that the human type II enzyme is subject to alternative splicing, as has been established for the type I enzyme. [provided by RefSeq, Jul 2008]
Chromosome	4
Cytoband	q31.21
Chromosome location (bp)	142023160 - 142847432
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000109452 (version 83.38)
Entrez gene	8821
UniProt	O15327 (UniProt - Evidence at transcript level)
neXtProt	NX_O15327
Antibodypedia	INPP4B antibodies

PROTEIN BROWSER

INPP4B-001	INPP4B-002	INPP4B-004	INPP4B-005	INPP4B-006	INPP4B-007	INPP4B-008	INPP4B-009	INPP4B-011	INPP4B-013	INPP4B-201	INPP4B-202

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
INPP4B-001 ENSP00000425487 ENST00000513000	O15327 [Direct mapping] Type II inositol 3,4-bisphosphate 4-phosphatase Show all	Enzymes ENZYME proteins Hydrolases SPOCTOPUS predicted membrane proteins Predicted intracellular proteins Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0005515 [protein binding] GO:0005623 [cell] GO:0005829 [cytosol] GO:0006644 [phospholipid metabolic process] GO:0006661 [phosphatidylinositol biosynthetic process] GO:0006874 [cellular calcium ion homeostasis] GO:0007165 [signal transduction] GO:0008289 [lipid binding] GO:0016311 [dephosphorylation] GO:0016316 [phosphatidylinositol-3,4-bisphosphate 4-phosphatase activity] GO:0034593 [phosphatidylinositol bisphosphate phosphatase activity] GO:0034594 [phosphatidylinositol trisphosphate phosphatase activity] GO:0034597 [phosphatidylinositol-4,5-bisphosphate 4-phosphatase activity] GO:0036092 [phosphatidylinositol-3-phosphate biosynthetic process] GO:0043647 [inositol phosphate metabolic process] GO:0044281 [small molecule metabolic process] GO:0045671 [negative regulation of osteoclast differentiation] GO:0046822 [regulation of nucleocytoplasmic transport] GO:0046850 [regulation of bone remodeling] GO:0051896 [regulation of protein kinase B signaling] Show all	924 aa 104.7 kDa	No	0
INPP4B-002 ENSP00000422793 ENST00000509777	E7EQN9 [Direct mapping] Type II inositol 3,4-bisphosphate 4-phosphatase Show all	Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 2TM proteins predicted by MDM Protein evidence (Ezkurdia et al 2014) Show all	GO:0005515 [protein binding] GO:0016021 [integral component of membrane] Show all	938 aa 106 kDa	No	2
INPP4B-004 ENSP00000426207 ENST00000511838	E9PCZ3 [Direct mapping] Type II inositol 3,4-bisphosphate 4-phosphatase Show all	SPOCTOPUS predicted membrane proteins Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all		688 aa 78.2 kDa	No	0
INPP4B-005 ENSP00000421065 ENST00000514525	E9PHC0 [Direct mapping] Type II inositol 3,4-bisphosphate 4-phosphatase Show all	SPOCTOPUS predicted membrane proteins Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all		686 aa 77.5 kDa	No	0
INPP4B-006 ENSP00000427250 ENST00000510812	D6RJC3 [Direct mapping] Type II inositol 3,4-bisphosphate 4-phosphatase Show all	SPOCTOPUS predicted membrane proteins Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0005515 [protein binding] Show all	817 aa 92.1 kDa	No	0
INPP4B-007 ENSP00000423954 ENST00000508116	O15327 [Direct mapping] Type II inositol 3,4-bisphosphate 4-phosphatase Show all	Enzymes ENZYME proteins Hydrolases SPOCTOPUS predicted membrane proteins Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0005515 [protein binding] GO:0005829 [cytosol] GO:0006644 [phospholipid metabolic process] GO:0006661 [phosphatidylinositol biosynthetic process] GO:0007165 [signal transduction] GO:0016311 [dephosphorylation] GO:0016316 [phosphatidylinositol-3,4-bisphosphate 4-phosphatase activity] GO:0034597 [phosphatidylinositol-4,5-bisphosphate 4-phosphatase activity] GO:0036092 [phosphatidylinositol-3-phosphate biosynthetic process] GO:0043647 [inositol phosphate metabolic process] GO:0044281 [small molecule metabolic process] Show all	924 aa 104.7 kDa	No	0
INPP4B-008 ENSP00000426897 ENST00000507861	Q9BS68 [Direct mapping] INPP4B protein; Type II inositol 3,4-bisphosphate 4-phosphatase Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all		53 aa 6 kDa	No	0
INPP4B-009 ENSP00000424057 ENST00000506217	O15327 [Direct mapping] Type II inositol 3,4-bisphosphate 4-phosphatase Show all	Enzymes ENZYME proteins Hydrolases Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0005515 [protein binding] GO:0005829 [cytosol] GO:0006644 [phospholipid metabolic process] GO:0006661 [phosphatidylinositol biosynthetic process] GO:0007165 [signal transduction] GO:0016311 [dephosphorylation] GO:0016316 [phosphatidylinositol-3,4-bisphosphate 4-phosphatase activity] GO:0034597 [phosphatidylinositol-4,5-bisphosphate 4-phosphatase activity] GO:0036092 [phosphatidylinositol-3-phosphate biosynthetic process] GO:0043647 [inositol phosphate metabolic process] GO:0044281 [small molecule metabolic process] Show all	131 aa 14.7 kDa	No	0
INPP4B-011 ENSP00000426957 ENST00000506788	D6RE59 [Direct mapping] Type II inositol 3,4-bisphosphate 4-phosphatase Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all		84 aa 9.4 kDa	No	0
INPP4B-013 ENSP00000422052 ENST00000503927	D6R9J5 [Direct mapping] Type II inositol 3,4-bisphosphate 4-phosphatase Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all		39 aa 4.3 kDa	No	0
INPP4B-201 ENSP00000262992 ENST00000262992	O15327 [Direct mapping] Type II inositol 3,4-bisphosphate 4-phosphatase Show all	Enzymes ENZYME proteins Hydrolases SPOCTOPUS predicted membrane proteins Predicted intracellular proteins Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0005515 [protein binding] GO:0005829 [cytosol] GO:0006644 [phospholipid metabolic process] GO:0006661 [phosphatidylinositol biosynthetic process] GO:0007165 [signal transduction] GO:0016311 [dephosphorylation] GO:0016316 [phosphatidylinositol-3,4-bisphosphate 4-phosphatase activity] GO:0034597 [phosphatidylinositol-4,5-bisphosphate 4-phosphatase activity] GO:0036092 [phosphatidylinositol-3-phosphate biosynthetic process] GO:0043647 [inositol phosphate metabolic process] GO:0044281 [small molecule metabolic process] Show all	924 aa 104.7 kDa	No	0
INPP4B-202 ENSP00000486368 ENST00000630044	Q9BS68 [Direct mapping] INPP4B protein; Type II inositol 3,4-bisphosphate 4-phosphatase Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all		53 aa 6 kDa	No	0

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