Tissue expression of GAB1 - Summary - The Human Protein Atlas

GENERAL INFORMATION
Gene name	GAB1
Gene description	GRB2-associated binding protein 1
Protein class	Predicted intracellular proteins RAS pathway related proteins
Predicted localization	Intracellular
Number of transcripts	7
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HUMAN PROTEIN ATLAS INFORMATION

RNA tissue category

HPA:	Expressed in all
GTEx:	Expressed in all
FANTOM5:	Expressed in all

Protein evidence

Evidence at protein level

DATA RELIABILITY
Reliability score	Pending normal tissue annotation.

RNA AND PROTEIN EXPRESSION SUMMARY

RNA expression (TPM)

Protein expression (score)

Brain

N/A

Cerebral cortex

N/A

Hippocampus

N/A

Caudate

N/A

Cerebellum

N/A

Endocrine tissues

N/A

Thyroid gland

N/A

Parathyroid gland

N/A

Adrenal gland

N/A

Bone marrow & immune system

N/A

Appendix

N/A

Bone marrow

N/A

Lymph node

N/A

Tonsil

N/A

Spleen

N/A

Muscle tissues

N/A

Heart muscle

N/A

Skeletal muscle

N/A

Smooth muscle

N/A

Lung

N/A

Nasopharynx

N/A

Bronchus

N/A

Lung

N/A

Liver & gallbladder

N/A

Liver

N/A

Gallbladder

N/A

Pancreas

N/A

Pancreas

N/A

Gastrointestinal tract

N/A

Oral mucosa

N/A

Salivary gland

N/A

Esophagus

N/A

Stomach

N/A

Duodenum

N/A

Small intestine

N/A

Colon

N/A

Rectum

N/A

Kidney & urinary bladder

N/A

Kidney

N/A

Urinary bladder

N/A

Male tissues

N/A

Testis

N/A

Epididymis

N/A

Prostate

N/A

Seminal vesicle

N/A

Female tissues

N/A

Breast

N/A

Vagina

N/A

Cervix, uterine

N/A

Endometrium

N/A

Fallopian tube

N/A

Ovary

N/A

Placenta

N/A

Adipose & soft tissue

N/A

Adipose tissue

N/A

Soft tissue

N/A

Skin

N/A

Skin

N/A

PROTEIN EXPRESSION OVERVIEW
Pending normal tissue annotation.

RNA EXPRESSION OVERVIEW
HPA dataset Organ Expression Alphabetical RNA tissue category: Expressed in all
GTEx dataset Organ Expression Alphabetical RNA tissue category: Expressed in all
FANTOM5 dataset Organ Expression Alphabetical RNA tissue category: Expressed in all

GENE INFORMATION
Gene name	GAB1
Synonyms
Description	GRB2-associated binding protein 1 (HGNC Symbol)
Entrez gene summary	The protein encoded by this gene is a member of the IRS1-like multisubstrate docking protein family. It is an important mediator of branching tubulogenesis and plays a central role in cellular growth response, transformation and apoptosis. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Aug 2008]
Chromosome	4
Cytoband	q31.21
Chromosome location (bp)	143336762 - 143474568
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000109458 (version 83.38)
Entrez gene	2549
UniProt	Q13480 (UniProt - Evidence at protein level)
neXtProt	NX_Q13480
Antibodypedia	GAB1 antibodies

PROTEIN BROWSER

GAB1-001	GAB1-002	GAB1-003	GAB1-005	GAB1-006	GAB1-008	GAB1-009

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
GAB1-001 ENSP00000262995 ENST00000262995	Q13480 [Direct mapping] GRB2-associated-binding protein 1 Show all	Predicted intracellular proteins RAS pathway related proteins Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0000187 [activation of MAPK activity] GO:0004871 [signal transducer activity] GO:0005070 [SH3/SH2 adaptor activity] GO:0005515 [protein binding] GO:0005737 [cytoplasm] GO:0005829 [cytosol] GO:0006979 [response to oxidative stress] GO:0007165 [signal transduction] GO:0007173 [epidermal growth factor receptor signaling pathway] GO:0007257 [activation of JUN kinase activity] GO:0007507 [heart development] GO:0008283 [cell proliferation] GO:0008286 [insulin receptor signaling pathway] GO:0008543 [fibroblast growth factor receptor signaling pathway] GO:0008544 [epidermis development] GO:0030334 [regulation of cell migration] GO:0038095 [Fc-epsilon receptor signaling pathway] GO:0043410 [positive regulation of MAPK cascade] GO:0045087 [innate immune response] GO:0048008 [platelet-derived growth factor receptor signaling pathway] GO:0048011 [neurotrophin TRK receptor signaling pathway] GO:0048015 [phosphatidylinositol-mediated signaling] GO:0060711 [labyrinthine layer development] GO:0070102 [interleukin-6-mediated signaling pathway] Show all	724 aa 80 kDa	No	0
GAB1-002 ENSP00000262994 ENST00000262994	Q13480 [Direct mapping] GRB2-associated-binding protein 1 Show all	Predicted intracellular proteins RAS pathway related proteins Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0005070 [SH3/SH2 adaptor activity] GO:0005515 [protein binding] GO:0005829 [cytosol] GO:0007173 [epidermal growth factor receptor signaling pathway] GO:0008283 [cell proliferation] GO:0008286 [insulin receptor signaling pathway] GO:0008543 [fibroblast growth factor receptor signaling pathway] GO:0038095 [Fc-epsilon receptor signaling pathway] GO:0045087 [innate immune response] GO:0048011 [neurotrophin TRK receptor signaling pathway] GO:0048015 [phosphatidylinositol-mediated signaling] Show all	694 aa 76.6 kDa	No	0
GAB1-003 ENSP00000424554 ENST00000505913	B7Z3B9 [Direct mapping] GRB2-associated-binding protein 1; cDNA FLJ53999, highly similar to GRB2-associated-binding protein 1 Show all	Predicted intracellular proteins RAS pathway related proteins Protein evidence (Ezkurdia et al 2014) Show all		591 aa 64.5 kDa	No	0
GAB1-005 ENSP00000426668 ENST00000515366	D6RF42 [Direct mapping] GRB2-associated-binding protein 1 Show all	Predicted intracellular proteins RAS pathway related proteins Protein evidence (Ezkurdia et al 2014) Show all		48 aa 5.1 kDa	No	0
GAB1-006 ENSP00000425921 ENST00000509992	D6RIF8 [Direct mapping] GRB2-associated-binding protein 1 Show all	Predicted intracellular proteins RAS pathway related proteins Protein evidence (Ezkurdia et al 2014) Show all		176 aa 20 kDa	No	0
GAB1-008 ENSP00000427435 ENST00000514639	D6RIS0 [Direct mapping] GRB2-associated-binding protein 1 Show all	Predicted intracellular proteins RAS pathway related proteins Protein evidence (Ezkurdia et al 2014) Show all		239 aa 26.9 kDa	No	0
GAB1-009 ENSP00000426297 ENST00000512843	H0YA71 [Direct mapping] GRB2-associated-binding protein 1 Show all	Predicted intracellular proteins RAS pathway related proteins Protein evidence (Ezkurdia et al 2014) Show all		91 aa 9.7 kDa	No	0