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GAR1

GENERAL INFORMATION

Gene name

 GAR1

Gene description

 GAR1 homolog, ribonucleoprotein

Protein class

 Plasma proteins
Predicted intracellular proteins

Predicted localization

 Intracellular

Number of transcripts

 2
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HUMAN PROTEIN ATLAS INFORMATION

RNA category
TCGA (cancer tissue):Expressed in all
HPA (cell line):Expressed in all
HPA (normal tissue):Expressed in all

Protein evidence

 Evidence at protein level

Protein expression
normal tissue

 Ubiquitous nuclear expression.

ANTIBODY IHC RELIABILITY

Data reliability
description

 Antibody staining mainly consistent with RNA expression data.

Reliability score

 Supported based on 1 antibody.
HPA059098
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PROGNOSTIC SUMMARY
Prognostic marker in liver cancer (unfavourable).
Liver cancer p<0.001
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RNA EXPRESSION OVERVIEW
TCGA dataset
RNA cancer category: Expressed in all

PROTEIN EXPRESSION
Colorectal cancer
Breast cancer
Prostate cancer
Lung cancer
Liver cancer

STAINING SUMMARY
HPA059098

GENE INFORMATION

Gene name

 GAR1 (HGNC Symbol)

Synonyms

 NOLA1

Description

 GAR1 homolog, ribonucleoprotein (HGNC Symbol)

Entrez gene summary

 This gene is a member of the H/ACA snoRNPs (small nucleolar ribonucleoproteins) gene family. snoRNPs are involved in various aspects of rRNA processing and modification and have been classified into two families: C/D and H/ACA. The H/ACA snoRNPs also include the DKC1, NOLA2 and NOLA3 proteins. These four H/ACA snoRNP proteins localize to the dense fibrillar components of nucleoli and to coiled (Cajal) bodies in the nucleus. Both 18S rRNA production and rRNA pseudouridylation are impaired if any one of the four proteins is depleted. These four H/ACA snoRNP proteins are also components of the telomerase complex. The encoded protein of this gene contains two glycine- and arginine-rich domains and is related to Saccharomyces cerevisiae Gar1p. Two splice variants have been found for this gene. [provided by RefSeq, Jul 2008]

Chromosome

 4

Cytoband

 q25

Chromosome location (bp)

 109815510 - 109824740

Protein evidence

 Evidence at protein level (all genes)

Ensembl

 ENSG00000109534 (version 83.38)

Entrez gene

 54433

UniProt

 Q9NY12 (UniProt - Evidence at protein level)

neXtProt

 NX_Q9NY12

Antibodypedia

 GAR1 antibodies

PROTEIN BROWSER
GAR1-001
GAR1-003

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)
GAR1-001
ENSP00000378127
ENST00000394631
Q9NY12 [Direct mapping]
H/ACA ribonucleoprotein complex subunit 1
A0A024RDJ3 [Target identity:100%; Query identity:100%]
Nucleolar protein family A, member 1 (H/ACA small nucleolar RNPs), isoform CRA_a
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Predicted intracellular proteins
Plasma proteins
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
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GO:0000784 [nuclear chromosome, telomeric region]
GO:0001522 [pseudouridine synthesis]
GO:0005261 [cation channel activity]
GO:0005634 [nucleus]
GO:0005697 [telomerase holoenzyme complex]
GO:0005730 [nucleolus]
GO:0006364 [rRNA processing]
GO:0007004 [telomere maintenance via telomerase]
GO:0031429 [box H/ACA snoRNP complex]
GO:0042254 [ribosome biogenesis]
GO:0044822 [poly(A) RNA binding]
GO:0072589 [box H/ACA scaRNP complex]
GO:0098655 [cation transmembrane transport]
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 217 aa
22.3 kDa 		No 0
GAR1-003
ENSP00000226796
ENST00000226796
Q9NY12 [Direct mapping]
H/ACA ribonucleoprotein complex subunit 1
A0A024RDJ3 [Target identity:100%; Query identity:100%]
Nucleolar protein family A, member 1 (H/ACA small nucleolar RNPs), isoform CRA_a
Show all
Predicted intracellular proteins
Plasma proteins
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000784 [nuclear chromosome, telomeric region]
GO:0001522 [pseudouridine synthesis]
GO:0005261 [cation channel activity]
GO:0005634 [nucleus]
GO:0005697 [telomerase holoenzyme complex]
GO:0005730 [nucleolus]
GO:0006364 [rRNA processing]
GO:0007004 [telomere maintenance via telomerase]
GO:0031429 [box H/ACA snoRNP complex]
GO:0042254 [ribosome biogenesis]
GO:0044822 [poly(A) RNA binding]
GO:0072589 [box H/ACA scaRNP complex]
GO:0098655 [cation transmembrane transport]
Show all
 217 aa
22.3 kDa 		No 0

Contact

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.