Cell atlas - CLCN3 - The Human Protein Atlas

We use cookies to enhance the usability of our website. If you continue, we'll assume that you are happy to receive all cookies. More information. Don't show this again.

CLCN3

TISSUE

CELL

PATHOLOGY

CELL ATLAS RNA EXPRESSION HUMAN CELLS

GENE/PROTEIN

Antibody validation

Dictionary
	Cytosol

Human cell
	Cytosol

Please wait until image is loaded before changing channels

GENERAL INFORMATION
Gene name	CLCN3
Gene description	Chloride channel, voltage-sensitive 3
Protein class	Predicted intracellular proteins Predicted membrane proteins
Predicted localization	Intracellular,Membrane
Number of transcripts	9
	SHOW MORE

HUMAN PROTEIN ATLAS INFORMATION
Summary	Localized to the cytosol.
RNA cell category	Expressed in all
Protein evidence	Evidence at protein level
Main location	Localized to the Cytosol (approved)

DATA RELIABILITY
Reliability score	Approved based on 1 antibody. HPA044723
	SHOW MORE

ASSAYS

RNA EXPRESSION OVERVIEW
RNA cell line category: Expressed in all Organ Origin Category Expression Alphabetical Cell lines sorted after organ of phenotypic resemblance. Cell lines sorted after biological source for establishment. Cell lines sorted after the cell line category according to Cellosaurus. Cell lines sorted on descending RNA expression. Cell lines sorted alphabetically.

HUMAN CELLS

Summary

Localized to the cytosol.

Main location

Cytosol (approved)


	Toggle channels	Low High G1 S G2 M N/A

Thumbnail	Antibody	Cell line	Location	Single-cell variation	Cell cycle dependent variation
	HPA044723	A-431	Cytosol
	HPA044723	U-2 OS	Cytosol

GENE INFORMATION
Gene name	CLCN3 (HGNC Symbol)
Synonyms	ClC-3, CLC3
Description	Chloride channel, voltage-sensitive 3 (HGNC Symbol)
Entrez gene summary	This gene encodes a member of the voltage-gated chloride channel (ClC) family. The encoded protein is present in all cell types and localized in plasma membranes and in intracellular vesicles. It is a multi-pass membrane protein which contains a ClC domain and two additional C-terminal CBS (cystathionine beta-synthase) domains. The ClC domain catalyzes the selective flow of Cl- ions across cell membranes, and the CBS domain may have a regulatory function. This protein plays a role in both acidification and transmitter loading of GABAergic synaptic vesicles, and in smooth muscle cell activation and neointima formation. This protein is required for lysophosphatidic acid (LPA)-activated Cl- current activity and fibroblast-to-myofibroblast differentiation. The protein activity is regulated by Ca(2+)/calmodulin-dependent protein kinase II (CaMKII) in glioma cells. Multiple alternatively spliced transcript variants encoding different isoforms have been identified. [provided by RefSeq, Aug 2011]
Chromosome	4
Cytoband	q33
Chromosome location (bp)	169612633 - 169723673
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000109572 (version 83.38)
Entrez gene	1182
UniProt	P51790 (UniProt - Evidence at protein level)
neXtProt	NX_P51790
Antibodypedia	CLCN3 antibodies

PROTEIN BROWSER

CLCN3-001	CLCN3-002	CLCN3-004	CLCN3-005	CLCN3-006	CLCN3-007	CLCN3-009	CLCN3-201	CLCN3-202

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
CLCN3-001 ENSP00000424603 ENST00000513761	P51790 [Direct mapping] H(+)/Cl(-) exchange transporter 3 Show all	Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based >9TM proteins predicted by MDM Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0000139 [Golgi membrane] GO:0005216 [ion channel activity] GO:0005247 [voltage-gated chloride channel activity] GO:0005254 [chloride channel activity] GO:0005515 [protein binding] GO:0005524 [ATP binding] GO:0005769 [early endosome] GO:0005770 [late endosome] GO:0005794 [Golgi apparatus] GO:0005886 [plasma membrane] GO:0006810 [transport] GO:0006821 [chloride transport] GO:0006885 [regulation of pH] GO:0008021 [synaptic vesicle] GO:0009897 [external side of plasma membrane] GO:0009986 [cell surface] GO:0012506 [vesicle membrane] GO:0015297 [antiporter activity] GO:0016020 [membrane] GO:0016021 [integral component of membrane] GO:0030141 [secretory granule] GO:0030165 [PDZ domain binding] GO:0030658 [transport vesicle membrane] GO:0031410 [cytoplasmic vesicle] GO:0031901 [early endosome membrane] GO:0031902 [late endosome membrane] GO:0034220 [ion transmembrane transport] GO:0042581 [specific granule] GO:0042803 [protein homodimerization activity] GO:0044070 [regulation of anion transport] GO:0045335 [phagocytic vesicle] GO:0045794 [negative regulation of cell volume] GO:0046982 [protein heterodimerization activity] GO:0048388 [endosomal lumen acidification] GO:0055085 [transmembrane transport] GO:0072320 [volume-sensitive chloride channel activity] GO:1902476 [chloride transmembrane transport] GO:1903959 [regulation of anion transmembrane transport] Show all	818 aa 91 kDa	No	>9
CLCN3-002 ENSP00000261514 ENST00000347613	P51790 [Direct mapping] H(+)/Cl(-) exchange transporter 3 Show all	Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based >9TM proteins predicted by MDM Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0000139 [Golgi membrane] GO:0005216 [ion channel activity] GO:0005244 [voltage-gated ion channel activity] GO:0005247 [voltage-gated chloride channel activity] GO:0005254 [chloride channel activity] GO:0005515 [protein binding] GO:0005524 [ATP binding] GO:0005768 [endosome] GO:0005769 [early endosome] GO:0005770 [late endosome] GO:0005794 [Golgi apparatus] GO:0005886 [plasma membrane] GO:0006810 [transport] GO:0006811 [ion transport] GO:0006821 [chloride transport] GO:0006885 [regulation of pH] GO:0006911 [phagocytosis, engulfment] GO:0008021 [synaptic vesicle] GO:0008344 [adult locomotory behavior] GO:0009897 [external side of plasma membrane] GO:0009986 [cell surface] GO:0012506 [vesicle membrane] GO:0015297 [antiporter activity] GO:0016020 [membrane] GO:0016021 [integral component of membrane] GO:0016324 [apical plasma membrane] GO:0030141 [secretory granule] GO:0030165 [PDZ domain binding] GO:0030658 [transport vesicle membrane] GO:0031410 [cytoplasmic vesicle] GO:0031901 [early endosome membrane] GO:0031902 [late endosome membrane] GO:0034220 [ion transmembrane transport] GO:0034765 [regulation of ion transmembrane transport] GO:0035249 [synaptic transmission, glutamatergic] GO:0042581 [specific granule] GO:0042803 [protein homodimerization activity] GO:0043679 [axon terminus] GO:0044070 [regulation of anion transport] GO:0045335 [phagocytic vesicle] GO:0045494 [photoreceptor cell maintenance] GO:0045794 [negative regulation of cell volume] GO:0046982 [protein heterodimerization activity] GO:0048388 [endosomal lumen acidification] GO:0051932 [synaptic transmission, GABAergic] GO:0055085 [transmembrane transport] GO:0070050 [neuron cellular homeostasis] GO:0072320 [volume-sensitive chloride channel activity] GO:0097401 [synaptic vesicle lumen acidification] GO:1902476 [chloride transmembrane transport] GO:1903428 [positive regulation of reactive oxygen species biosynthetic process] GO:1903959 [regulation of anion transmembrane transport] Show all	866 aa 96.7 kDa	No	>9
CLCN3-004 ENSP00000353857 ENST00000360642	P51790 [Direct mapping] H(+)/Cl(-) exchange transporter 3 Show all	Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based >9TM proteins predicted by MDM Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0000139 [Golgi membrane] GO:0005216 [ion channel activity] GO:0005247 [voltage-gated chloride channel activity] GO:0005254 [chloride channel activity] GO:0005515 [protein binding] GO:0005524 [ATP binding] GO:0005769 [early endosome] GO:0005770 [late endosome] GO:0005794 [Golgi apparatus] GO:0005886 [plasma membrane] GO:0006810 [transport] GO:0006821 [chloride transport] GO:0006885 [regulation of pH] GO:0008021 [synaptic vesicle] GO:0009897 [external side of plasma membrane] GO:0009986 [cell surface] GO:0012506 [vesicle membrane] GO:0015297 [antiporter activity] GO:0016020 [membrane] GO:0016021 [integral component of membrane] GO:0030141 [secretory granule] GO:0030165 [PDZ domain binding] GO:0030658 [transport vesicle membrane] GO:0031410 [cytoplasmic vesicle] GO:0031901 [early endosome membrane] GO:0031902 [late endosome membrane] GO:0034220 [ion transmembrane transport] GO:0042581 [specific granule] GO:0042803 [protein homodimerization activity] GO:0044070 [regulation of anion transport] GO:0045335 [phagocytic vesicle] GO:0045794 [negative regulation of cell volume] GO:0046982 [protein heterodimerization activity] GO:0048388 [endosomal lumen acidification] GO:0055085 [transmembrane transport] GO:0072320 [volume-sensitive chloride channel activity] GO:1902476 [chloride transmembrane transport] GO:1903959 [regulation of anion transmembrane transport] Show all	791 aa 88.5 kDa	No	>9
CLCN3-005 ENSP00000425323 ENST00000507875	E9PE15 [Direct mapping] Chloride channel protein Show all	Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based >9TM proteins predicted by MDM Protein evidence (Ezkurdia et al 2014) Show all	GO:0005216 [ion channel activity] GO:0005247 [voltage-gated chloride channel activity] GO:0006821 [chloride transport] GO:0016020 [membrane] GO:0016021 [integral component of membrane] GO:0034220 [ion transmembrane transport] GO:0055085 [transmembrane transport] GO:1903959 [regulation of anion transmembrane transport] Show all	725 aa 80.5 kDa	No	>9
CLCN3-006 ENSP00000425160 ENST00000511092	D6RDZ6 [Direct mapping] H(+)/Cl(-) exchange transporter 3 Show all	Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 1TM proteins predicted by MDM Protein evidence (Ezkurdia et al 2014) Show all	GO:0005216 [ion channel activity] GO:0005247 [voltage-gated chloride channel activity] GO:0006821 [chloride transport] GO:0016020 [membrane] GO:0034220 [ion transmembrane transport] GO:0055085 [transmembrane transport] GO:1903959 [regulation of anion transmembrane transport] Show all	173 aa 19.4 kDa	No	1
CLCN3-007 ENSP00000425823 ENST00000512813	D6RIX3 [Direct mapping] H(+)/Cl(-) exchange transporter 3 Show all	MEMSAT3 predicted membrane proteins SPOCTOPUS predicted membrane proteins Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0005247 [voltage-gated chloride channel activity] GO:0006821 [chloride transport] GO:0016020 [membrane] GO:1903959 [regulation of anion transmembrane transport] Show all	139 aa 15.7 kDa	No	0
CLCN3-009 ENSP00000422678 ENST00000515420	H0Y8Z8 [Direct mapping] H(+)/Cl(-) exchange transporter 3 Show all	Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 6TM proteins predicted by MDM Protein evidence (Ezkurdia et al 2014) Show all	GO:0005216 [ion channel activity] GO:0005247 [voltage-gated chloride channel activity] GO:0006821 [chloride transport] GO:0016020 [membrane] GO:0016021 [integral component of membrane] GO:0034220 [ion transmembrane transport] GO:0055085 [transmembrane transport] GO:1903959 [regulation of anion transmembrane transport] Show all	245 aa 26.7 kDa	No	6
CLCN3-201 ENSP00000424540 ENST00000504131	A0A0A0MTB7 [Direct mapping] Chloride channel protein Show all	Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based >9TM proteins predicted by MDM Protein evidence (Ezkurdia et al 2014) Show all	GO:0005216 [ion channel activity] GO:0005247 [voltage-gated chloride channel activity] GO:0006821 [chloride transport] GO:0016020 [membrane] GO:0016021 [integral component of membrane] GO:0034220 [ion transmembrane transport] GO:0055085 [transmembrane transport] GO:1903959 [regulation of anion transmembrane transport] Show all	801 aa 88.8 kDa	No	>9
CLCN3-202 ENSP00000478336 ENST00000613795	A0A087WU31 [Direct mapping] Chloride channel protein Show all	Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based >9TM proteins predicted by MDM Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0005216 [ion channel activity] GO:0005247 [voltage-gated chloride channel activity] GO:0006821 [chloride transport] GO:0016020 [membrane] GO:0016021 [integral component of membrane] GO:0034220 [ion transmembrane transport] GO:0055085 [transmembrane transport] GO:1903959 [regulation of anion transmembrane transport] Show all	791 aa 87.9 kDa	No	>9

Contact

contact@proteinatlas.org

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.