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AADAT

GENERAL INFORMATION

Gene name

 AADAT

Gene description

 Aminoadipate aminotransferase

Protein class

 Enzymes
Predicted intracellular proteins

Predicted localization

 Intracellular

Number of transcripts

 7
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HUMAN PROTEIN ATLAS INFORMATION

RNA category
TCGA (cancer tissue):Expressed in all
HPA (cell line):Mixed
HPA (normal tissue):Tissue enhanced (liver)

Protein evidence

 Evidence at protein level

Protein expression
normal tissue

 Cytoplasmic expression in liver, renal tubules and low expression in the gastrointestinal tract.

ANTIBODY IHC RELIABILITY

Data reliability
description

 Antibody staining mainly consistent with RNA expression data.

Reliability score

 Supported based on 1 antibody.
HPA037502
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PROGNOSTIC SUMMARY
Prognostic marker in colorectal cancer (favourable).
Colorectal cancer p<0.001
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RNA EXPRESSION OVERVIEW
TCGA dataset
RNA cancer category: Expressed in all

PROTEIN EXPRESSION
Colorectal cancer
Breast cancer
Prostate cancer
Lung cancer

STAINING SUMMARY
HPA037502

GENE INFORMATION

Gene name

 AADAT (HGNC Symbol)

Synonyms

 KAT2, KATII

Description

 Aminoadipate aminotransferase (HGNC Symbol)

Entrez gene summary

 This gene encodes a protein that is highly similar to mouse and rat kynurenine aminotransferase II. The rat protein is a homodimer with two transaminase activities. One activity is the transamination of alpha-aminoadipic acid, a final step in the saccaropine pathway which is the major pathway for L-lysine catabolism. The other activity involves the transamination of kynurenine to produce kynurenine acid, the precursor of kynurenic acid which has neuroprotective properties. Several transcript variants encoding two different isoforms have been found for this gene. [provided by RefSeq, Nov 2013]

Chromosome

 4

Cytoband

 q33

Chromosome location (bp)

 170060222 - 170091699

Protein evidence

 Evidence at protein level (all genes)

Ensembl

 ENSG00000109576 (version 83.38)

Entrez gene

 51166

UniProt

 Q8N5Z0 (UniProt - Evidence at protein level)

neXtProt

 NX_Q8N5Z0

Antibodypedia

 AADAT antibodies

PROTEIN BROWSER
AADAT-001
AADAT-002
AADAT-003
AADAT-004
AADAT-005
AADAT-006
AADAT-007

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)
AADAT-001
ENSP00000423341
ENST00000515480
Q8N5Z0 [Direct mapping]
Kynurenine/alpha-aminoadipate aminotransferase, mitochondrial
Q4W5N8 [Target identity:100%; Query identity:100%]
Aminoadipate aminotransferase, isoform CRA_b; Putative uncharacterized protein AADAT; cDNA, FLJ95590, Homo sapiens L-kynurenine/alpha-aminoadipate aminotransferase (KATII), mRNA
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Enzymes
   ENZYME proteins
   Transferases
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0005759 [mitochondrial matrix]
GO:0006103 [2-oxoglutarate metabolic process]
GO:0006536 [glutamate metabolic process]
GO:0006554 [lysine catabolic process]
GO:0006569 [tryptophan catabolic process]
GO:0009058 [biosynthetic process]
GO:0016212 [kynurenine-oxoglutarate transaminase activity]
GO:0030170 [pyridoxal phosphate binding]
GO:0033512 [L-lysine catabolic process to acetyl-CoA via saccharopine]
GO:0034641 [cellular nitrogen compound metabolic process]
GO:0042803 [protein homodimerization activity]
GO:0044281 [small molecule metabolic process]
GO:0047536 [2-aminoadipate transaminase activity]
GO:0070189 [kynurenine metabolic process]
GO:0097052 [L-kynurenine metabolic process]
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 425 aa
47.4 kDa 		No 0
AADAT-002
ENSP00000423190
ENST00000509167
Q8N5Z0 [Direct mapping]
Kynurenine/alpha-aminoadipate aminotransferase, mitochondrial
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Enzymes
   ENZYME proteins
   Transferases
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0005739 [mitochondrion]
GO:0005759 [mitochondrial matrix]
GO:0006103 [2-oxoglutarate metabolic process]
GO:0006536 [glutamate metabolic process]
GO:0006554 [lysine catabolic process]
GO:0006569 [tryptophan catabolic process]
GO:0009058 [biosynthetic process]
GO:0016212 [kynurenine-oxoglutarate transaminase activity]
GO:0019441 [tryptophan catabolic process to kynurenine]
GO:0030170 [pyridoxal phosphate binding]
GO:0033512 [L-lysine catabolic process to acetyl-CoA via saccharopine]
GO:0034641 [cellular nitrogen compound metabolic process]
GO:0042803 [protein homodimerization activity]
GO:0044281 [small molecule metabolic process]
GO:0047536 [2-aminoadipate transaminase activity]
GO:0070189 [kynurenine metabolic process]
GO:0097052 [L-kynurenine metabolic process]
Show all
 429 aa
47.8 kDa 		No 0
AADAT-003
ENSP00000226840
ENST00000353187
Q8N5Z0 [Direct mapping]
Kynurenine/alpha-aminoadipate aminotransferase, mitochondrial
Q4W5N8 [Target identity:100%; Query identity:100%]
Aminoadipate aminotransferase, isoform CRA_b; Putative uncharacterized protein AADAT; cDNA, FLJ95590, Homo sapiens L-kynurenine/alpha-aminoadipate aminotransferase (KATII), mRNA
Show all
Enzymes
   ENZYME proteins
   Transferases
Predicted intracellular proteins
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0005759 [mitochondrial matrix]
GO:0006103 [2-oxoglutarate metabolic process]
GO:0006536 [glutamate metabolic process]
GO:0006554 [lysine catabolic process]
GO:0006569 [tryptophan catabolic process]
GO:0009058 [biosynthetic process]
GO:0016212 [kynurenine-oxoglutarate transaminase activity]
GO:0030170 [pyridoxal phosphate binding]
GO:0033512 [L-lysine catabolic process to acetyl-CoA via saccharopine]
GO:0034641 [cellular nitrogen compound metabolic process]
GO:0042803 [protein homodimerization activity]
GO:0044281 [small molecule metabolic process]
GO:0047536 [2-aminoadipate transaminase activity]
GO:0070189 [kynurenine metabolic process]
GO:0097052 [L-kynurenine metabolic process]
Show all
 425 aa
47.4 kDa 		No 0
AADAT-004
ENSP00000336808
ENST00000337664
Q8N5Z0 [Direct mapping]
Kynurenine/alpha-aminoadipate aminotransferase, mitochondrial
Q4W5N8 [Target identity:100%; Query identity:100%]
Aminoadipate aminotransferase, isoform CRA_b; Putative uncharacterized protein AADAT; cDNA, FLJ95590, Homo sapiens L-kynurenine/alpha-aminoadipate aminotransferase (KATII), mRNA
Show all
Enzymes
   ENZYME proteins
   Transferases
Predicted intracellular proteins
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0005759 [mitochondrial matrix]
GO:0006103 [2-oxoglutarate metabolic process]
GO:0006536 [glutamate metabolic process]
GO:0006554 [lysine catabolic process]
GO:0006569 [tryptophan catabolic process]
GO:0009058 [biosynthetic process]
GO:0016212 [kynurenine-oxoglutarate transaminase activity]
GO:0030170 [pyridoxal phosphate binding]
GO:0033512 [L-lysine catabolic process to acetyl-CoA via saccharopine]
GO:0034641 [cellular nitrogen compound metabolic process]
GO:0042803 [protein homodimerization activity]
GO:0044281 [small molecule metabolic process]
GO:0047536 [2-aminoadipate transaminase activity]
GO:0070189 [kynurenine metabolic process]
GO:0097052 [L-kynurenine metabolic process]
Show all
 425 aa
47.4 kDa 		No 0
AADAT-005
ENSP00000423843
ENST00000502392
D6RC56 [Direct mapping]
Kynurenine/alpha-aminoadipate aminotransferase, mitochondrial
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Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0003824 [catalytic activity]
GO:0009058 [biosynthetic process]
GO:0030170 [pyridoxal phosphate binding]
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 180 aa
19.7 kDa 		No 0
AADAT-006
ENSP00000421389
ENST00000507375
D6RFY7 [Direct mapping]
Kynurenine/alpha-aminoadipate aminotransferase, mitochondrial
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Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0003824 [catalytic activity]
GO:0009058 [biosynthetic process]
GO:0030170 [pyridoxal phosphate binding]
Show all
 209 aa
22.8 kDa 		No 0
AADAT-007
ENSP00000425067
ENST00000510340
D6REB9 [Direct mapping]
Kynurenine/alpha-aminoadipate aminotransferase, mitochondrial
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Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0003824 [catalytic activity]
GO:0009058 [biosynthetic process]
GO:0030170 [pyridoxal phosphate binding]
Show all
 220 aa
24.4 kDa 		No 0

Contact

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.