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DHX15

GENERAL INFORMATION

Gene name

 DHX15

Gene description

 DEAH (Asp-Glu-Ala-His) box helicase 15

Protein class

 Enzymes
Plasma proteins
Predicted intracellular proteins

Predicted localization

 Intracellular

Number of transcripts

 1
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HUMAN PROTEIN ATLAS INFORMATION

RNA category
TCGA (cancer tissue):Expressed in all
HPA (cell line):Expressed in all
HPA (normal tissue):Expressed in all

Protein evidence

 Evidence at protein level

Protein expression
normal tissue

 Nuclear and nucleolar expression in several tissues.

ANTIBODY IHC RELIABILITY

Data reliability
description

 Antibody staining mainly not consistent with RNA expression data. Pending external verification. Cytoplasmic staining observed and disregarded.

Reliability score

 Approved based on 1 antibody.
HPA047047
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PROGNOSTIC SUMMARY
Prognostic marker in colorectal cancer (favourable).
Colorectal cancer p<0.001
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RNA EXPRESSION OVERVIEW
TCGA dataset
RNA cancer category: Expressed in all

PROTEIN EXPRESSION
Colorectal cancer
Breast cancer
Prostate cancer
Lung cancer
Liver cancer

STAINING SUMMARY
HPA047047

GENE INFORMATION

Gene name

 DHX15 (HGNC Symbol)

Synonyms

 DBP1, DDX15, HRH2, PRP43, PRPF43, PrPp43p

Description

 DEAH (Asp-Glu-Ala-His) box helicase 15 (HGNC Symbol)

Entrez gene summary

 The protein encoded by this gene is a putative ATP-dependent RNA helicase implicated in pre-mRNA splicing. [provided by RefSeq, Jul 2008]

Chromosome

 4

Cytoband

 p15.2

Chromosome location (bp)

 24517441 - 24584550

Protein evidence

 Evidence at protein level (all genes)

Ensembl

 ENSG00000109606 (version 83.38)

Entrez gene

 1665

UniProt

 O43143 (UniProt - Evidence at protein level)

neXtProt

 NX_O43143

Antibodypedia

 DHX15 antibodies

PROTEIN BROWSER
DHX15-001

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)
DHX15-001
ENSP00000336741
ENST00000336812
O43143 [Direct mapping]
Pre-mRNA-splicing factor ATP-dependent RNA helicase DHX15
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Enzymes
   ENZYME proteins
   Hydrolases
   SPOCTOPUS predicted membrane proteins
Predicted intracellular proteins
Plasma proteins
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
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GO:0003676 [nucleic acid binding]
GO:0003724 [RNA helicase activity]
GO:0003725 [double-stranded RNA binding]
GO:0004004 [ATP-dependent RNA helicase activity]
GO:0004386 [helicase activity]
GO:0005515 [protein binding]
GO:0005524 [ATP binding]
GO:0005634 [nucleus]
GO:0005654 [nucleoplasm]
GO:0005689 [U12-type spliceosomal complex]
GO:0005730 [nucleolus]
GO:0005737 [cytoplasm]
GO:0006397 [mRNA processing]
GO:0008026 [ATP-dependent helicase activity]
GO:0008380 [RNA splicing]
GO:0009636 [response to toxic substance]
GO:0043279 [response to alkaloid]
GO:0044822 [poly(A) RNA binding]
GO:0071008 [U2-type post-mRNA release spliceosomal complex]
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 795 aa
90.9 kDa 		No 0

Contact

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.