Expression of MFSD10 in cancer - Summary - The Human Protein Atlas

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MFSD10

TISSUE

CELL

PATHOLOGY

PATHOLOGY ATLAS

GENE/PROTEIN

Antibody validation

Dictionary


Level of antibody staining/expression
	High Medium Low Not detected

GENERAL INFORMATION
Gene name	MFSD10
Gene description	Major facilitator superfamily domain containing 10
Protein class	Predicted membrane proteins
Predicted localization	Membrane
Number of transcripts	5
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HUMAN PROTEIN ATLAS INFORMATION

RNA category

TCGA (cancer tissue):	Expressed in all
HPA (cell line):	Expressed in all
HPA (normal tissue):	Expressed in all

Protein evidence

Evidence at protein level

Protein expression
normal tissue

Nuclear expression at variable levels in several different tissues.

ANTIBODY IHC RELIABILITY
Data reliability description	Pending external verification.
Reliability score	Uncertain based on 1 antibody. HPA043209
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PROGNOSTIC SUMMARY
Prognostic marker in renal cancer (unfavourable) and liver cancer (unfavourable).
Renal cancer p<0.001 Liver cancer p<0.001 Show all

RNA EXPRESSION OVERVIEW
TCGA dataset RNA cancer category: Expressed in all

PROTEIN EXPRESSION

Colorectal cancer

Prostate cancer

STAINING SUMMARY

HPA043209

GENE INFORMATION
Gene name	MFSD10 (HGNC Symbol)
Synonyms	IT10C3, TETRAN
Description	Major facilitator superfamily domain containing 10 (HGNC Symbol)
Entrez gene summary	This gene encodes a member of the major facilitator superfamily of transporter proteins. The encoded protein likely functions in efflux of organic anions, including the non-steroidal anti-inflammatory drugs indomethacin and diclofenac. Alternatively spliced transcript variants have been described. [provided by RefSeq, Mar 2009]
Chromosome	4
Cytoband	p16.3
Chromosome location (bp)	2930561 - 2934859
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000109736 (version 83.38)
Entrez gene	10227
UniProt	Q14728 (UniProt - Evidence at protein level)
neXtProt	NX_Q14728
Antibodypedia	MFSD10 antibodies

PROTEIN BROWSER

MFSD10-001	MFSD10-002	MFSD10-004	MFSD10-007	MFSD10-010

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
MFSD10-001 ENSP00000347619 ENST00000355443	Q14728 [Direct mapping] Major facilitator superfamily domain-containing protein 10 Show all	Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based >9TM proteins predicted by MDM Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0006810 [transport] GO:0006915 [apoptotic process] GO:0008493 [tetracycline transporter activity] GO:0008514 [organic anion transmembrane transporter activity] GO:0015904 [tetracycline transport] GO:0016021 [integral component of membrane] GO:0022891 [substrate-specific transmembrane transporter activity] GO:0030659 [cytoplasmic vesicle membrane] GO:0031526 [brush border membrane] GO:0043252 [sodium-independent organic anion transport] GO:0055085 [transmembrane transport] Show all	455 aa 48.3 kDa	No	>9
MFSD10-002 ENSP00000423402 ENST00000507555	D6RA47 [Direct mapping] Major facilitator superfamily domain-containing protein 10 Show all	Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 7TM proteins predicted by MDM Protein evidence (Ezkurdia et al 2014) Show all	GO:0016021 [integral component of membrane] GO:0055085 [transmembrane transport] Show all	366 aa 39.2 kDa	No	7
MFSD10-004 ENSP00000425757 ENST00000508221	D6RIZ4 [Direct mapping] Major facilitator superfamily domain-containing protein 10 Show all	Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 8TM proteins predicted by MDM Protein evidence (Ezkurdia et al 2014) Show all	GO:0016021 [integral component of membrane] GO:0055085 [transmembrane transport] Show all	356 aa 38.2 kDa	No	8
MFSD10-007 ENSP00000426907 ENST00000514800	D6RE79 [Direct mapping] Major facilitator superfamily domain-containing protein 10 Show all	Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based >9TM proteins predicted by MDM Protein evidence (Ezkurdia et al 2014) Show all	GO:0016021 [integral component of membrane] GO:0055085 [transmembrane transport] Show all	480 aa 50.4 kDa	No	>9
MFSD10-010 ENSP00000332646 ENST00000329687	Q14728 [Direct mapping] Major facilitator superfamily domain-containing protein 10 Show all	Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based >9TM proteins predicted by MDM Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0006810 [transport] GO:0006915 [apoptotic process] GO:0008493 [tetracycline transporter activity] GO:0008514 [organic anion transmembrane transporter activity] GO:0015904 [tetracycline transport] GO:0016021 [integral component of membrane] GO:0022891 [substrate-specific transmembrane transporter activity] GO:0030659 [cytoplasmic vesicle membrane] GO:0031526 [brush border membrane] GO:0043252 [sodium-independent organic anion transport] GO:0055085 [transmembrane transport] Show all	455 aa 48.3 kDa	No	>9

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The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.