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Gene name

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Chromosome

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In atlas

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RAPGEF2
  • TISSUE

  • CELL

  • PATHOLOGY

TISSUE ATLAS

GENE/PROTEIN

Dictionary


Tissue proteome

GENERAL INFORMATION

Gene name

RAPGEF2

Gene description

Rap guanine nucleotide exchange factor (GEF) 2

Protein class

Predicted intracellular proteins

Predicted localization

Intracellular

Number of transcripts

9
SHOW MORE

HUMAN PROTEIN ATLAS INFORMATION

RNA tissue category

HPA:Expressed in all
GTEx:Expressed in all
FANTOM5:Tissue enhanced (brain, caudate)

Protein evidence

Evidence at protein level

DATA RELIABILITY

Reliability score

Pending normal tissue annotation.

RNA AND PROTEIN EXPRESSION SUMMARY

RNA expression (TPM) Protein expression (score)
Brain
N/A
Cerebral cortex
N/A
Hippocampus
N/A
N/A
Caudate
N/A
N/A
Cerebellum
N/A
N/A
Endocrine tissues
N/A
Thyroid gland
N/A
Parathyroid gland
N/A
Adrenal gland
N/A
Bone marrow & immune system
N/A
Appendix
N/A
Bone marrow
N/A
Lymph node
N/A
Tonsil
N/A
Spleen
N/A
Muscle tissues
N/A
Heart muscle
N/A
Skeletal muscle
N/A
Smooth muscle
N/A
Lung
N/A
Nasopharynx
N/A
N/A
Bronchus
N/A
N/A
Lung
N/A
Liver & gallbladder
N/A
Liver
N/A
Gallbladder
N/A
Pancreas
N/A
Pancreas
N/A
Gastrointestinal tract
N/A
Oral mucosa
N/A
N/A
Salivary gland
N/A
Esophagus
N/A
Stomach
N/A
Duodenum
N/A
Small intestine
N/A
Colon
N/A
Rectum
N/A
Kidney & urinary bladder
N/A
Kidney
N/A
Urinary bladder
N/A
Male tissues
N/A
Testis
N/A
Epididymis
N/A
Prostate
N/A
Seminal vesicle
N/A
Female tissues
N/A
Breast
N/A
Vagina
N/A
N/A
Cervix, uterine
N/A
Endometrium
N/A
Fallopian tube
N/A
Ovary
N/A
Placenta
N/A
Adipose & soft tissue
N/A
Adipose tissue
N/A
Soft tissue
N/A
N/A
Skin
N/A
Skin
N/A

PROTEIN EXPRESSION OVERVIEW

Pending normal tissue annotation.

RNA EXPRESSION OVERVIEW

HPA dataset
Organ
Expression
Alphabetical
RNA tissue category: Expressed in all
GTEx dataset
Organ
Expression
Alphabetical
RNA tissue category: Expressed in all
FANTOM5 dataset
Organ
Expression
Alphabetical
RNA tissue category: Tissue enhanced (brain, caudate)

GENE INFORMATION

Gene name

RAPGEF2 (HGNC Symbol)

Synonyms

DKFZP586O1422, KIAA0313, PDZ-GEF1, PDZGEF1, RA-GEF

Description

Rap guanine nucleotide exchange factor (GEF) 2 (HGNC Symbol)

Entrez gene summary

Members of the RAS (see HRAS; MIM 190020) subfamily of GTPases function in signal transduction as GTP/GDP-regulated switches that cycle between inactive GDP- and active GTP-bound states. Guanine nucleotide exchange factors (GEFs), such as RAPGEF2, serve as RAS activators by promoting acquisition of GTP to maintain the active GTP-bound state and are the key link between cell surface receptors and RAS activation (Rebhun et al., 2000 [PubMed 10934204]).[supplied by OMIM, Mar 2008]

Chromosome

4

Cytoband

q32.1

Chromosome location (bp)

159104178 - 159360169

Protein evidence

Evidence at protein level (all genes)

Ensembl

ENSG00000109756 (version 83.38)

Entrez gene

9693

UniProt

Q9Y4G8 (UniProt - Evidence at protein level)

neXtProt

NX_Q9Y4G8

Antibodypedia

RAPGEF2 antibodies

PROTEIN BROWSER

RAPGEF2-001
RAPGEF2-003
RAPGEF2-006
RAPGEF2-007
RAPGEF2-008
RAPGEF2-009
RAPGEF2-010
RAPGEF2-011
RAPGEF2-013

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)

RAPGEF2-001
ENSP00000264431
ENST00000264431
Q9Y4G8 [Direct mapping]
Rap guanine nucleotide exchange factor 2
Show all
Predicted intracellular proteins
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000165 [MAPK cascade]
GO:0000186 [activation of MAPKK activity]
GO:0001568 [blood vessel development]
GO:0001764 [neuron migration]
GO:0004871 [signal transducer activity]
GO:0005085 [guanyl-nucleotide exchange factor activity]
GO:0005088 [Ras guanyl-nucleotide exchange factor activity]
GO:0005096 [GTPase activator activity]
GO:0005509 [calcium ion binding]
GO:0005515 [protein binding]
GO:0005737 [cytoplasm]
GO:0005770 [late endosome]
GO:0005829 [cytosol]
GO:0005886 [plasma membrane]
GO:0005887 [integral component of plasma membrane]
GO:0005911 [cell-cell junction]
GO:0005923 [bicellular tight junction]
GO:0007165 [signal transduction]
GO:0007173 [epidermal growth factor receptor signaling pathway]
GO:0007186 [G-protein coupled receptor signaling pathway]
GO:0007218 [neuropeptide signaling pathway]
GO:0007264 [small GTPase mediated signal transduction]
GO:0007265 [Ras protein signal transduction]
GO:0007411 [axon guidance]
GO:0008285 [negative regulation of cell proliferation]
GO:0008286 [insulin receptor signaling pathway]
GO:0008543 [fibroblast growth factor receptor signaling pathway]
GO:0010976 [positive regulation of neuron projection development]
GO:0016020 [membrane]
GO:0016324 [apical plasma membrane]
GO:0017034 [Rap guanyl-nucleotide exchange factor activity]
GO:0019933 [cAMP-mediated signaling]
GO:0019992 [diacylglycerol binding]
GO:0021591 [ventricular system development]
GO:0021884 [forebrain neuron development]
GO:0030033 [microvillus assembly]
GO:0030139 [endocytic vesicle]
GO:0030165 [PDZ domain binding]
GO:0030552 [cAMP binding]
GO:0031175 [neuron projection development]
GO:0031547 [brain-derived neurotrophic factor receptor signaling pathway]
GO:0031697 [beta-1 adrenergic receptor binding]
GO:0032092 [positive regulation of protein binding]
GO:0032486 [Rap protein signal transduction]
GO:0035556 [intracellular signal transduction]
GO:0038095 [Fc-epsilon receptor signaling pathway]
GO:0038180 [nerve growth factor signaling pathway]
GO:0043005 [neuron projection]
GO:0043025 [neuronal cell body]
GO:0043234 [protein complex]
GO:0043547 [positive regulation of GTPase activity]
GO:0043950 [positive regulation of cAMP-mediated signaling]
GO:0045087 [innate immune response]
GO:0045202 [synapse]
GO:0045860 [positive regulation of protein kinase activity]
GO:0048010 [vascular endothelial growth factor receptor signaling pathway]
GO:0048011 [neurotrophin TRK receptor signaling pathway]
GO:0048022 [negative regulation of melanin biosynthetic process]
GO:0048167 [regulation of synaptic plasticity]
GO:0048471 [perinuclear region of cytoplasm]
GO:0050699 [WW domain binding]
GO:0050774 [negative regulation of dendrite morphogenesis]
GO:0061028 [establishment of endothelial barrier]
GO:0070300 [phosphatidic acid binding]
GO:0070374 [positive regulation of ERK1 and ERK2 cascade]
GO:0071320 [cellular response to cAMP]
GO:0071321 [cellular response to cGMP]
GO:0071880 [adenylate cyclase-activating adrenergic receptor signaling pathway]
GO:0072659 [protein localization to plasma membrane]
GO:0090557 [establishment of endothelial intestinal barrier]
GO:1901888 [regulation of cell junction assembly]
GO:1990090 [cellular response to nerve growth factor stimulus]
GO:2000481 [positive regulation of cAMP-dependent protein kinase activity]
GO:2000670 [positive regulation of dendritic cell apoptotic process]
GO:2001214 [positive regulation of vasculogenesis]
GO:2001224 [positive regulation of neuron migration]
Show all
1499 aa
167.4 kDa
No 0
RAPGEF2-003
ENSP00000422707
ENST00000505478
H0Y905 [Direct mapping]
Rap guanine nucleotide exchange factor 2
Show all
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
279 aa
31.9 kDa
No 0
RAPGEF2-006
ENSP00000422361
ENST00000514565
D6RC78 [Direct mapping]
Rap guanine nucleotide exchange factor 2
Show all
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
154 aa
17 kDa
No 0
RAPGEF2-007
ENSP00000421602
ENST00000511336
D6REY8 [Direct mapping]
Rap guanine nucleotide exchange factor 2
Show all
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
116 aa
13 kDa
No 0
RAPGEF2-008
ENSP00000421740
ENST00000510510
D6RAK0 [Direct mapping]
Rap guanine nucleotide exchange factor 2
Show all
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
155 aa
17.2 kDa
No 0
RAPGEF2-009
ENSP00000422098
ENST00000502485
H0Y8T6 [Direct mapping]
Rap guanine nucleotide exchange factor 2
Show all
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
182 aa
20.1 kDa
No 0
RAPGEF2-010
ENSP00000421083
ENST00000510253
H0Y8H7 [Direct mapping]
Rap guanine nucleotide exchange factor 2
Show all
   SCAMPI predicted membrane proteins
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
266 aa
28.6 kDa
No 0
RAPGEF2-011
ENSP00000427334
ENST00000505026
H0YAJ8 [Direct mapping]
Rap guanine nucleotide exchange factor 2
Show all
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
324 aa
34.5 kDa
No 0
RAPGEF2-013
ENSP00000421624
ENST00000512056
H0Y8N8 [Direct mapping]
Rap guanine nucleotide exchange factor 2
Show all
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0005515 [protein binding]
Show all
189 aa
20.8 kDa
No 0

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The Human Protein Atlas project is funded
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