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KLF3

GENERAL INFORMATION

Gene name

 KLF3

Gene description

 Kruppel-like factor 3 (basic)

Protein class

 Predicted intracellular proteins
Transcription factors

Predicted localization

 Intracellular

Number of transcripts

 2
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HUMAN PROTEIN ATLAS INFORMATION

RNA category
TCGA (cancer tissue):Expressed in all
HPA (cell line):Mixed
HPA (normal tissue):Expressed in all

Protein evidence

 Evidence at protein level

Protein expression
normal tissue

 Ubiquitous nuclear expression.

ANTIBODY IHC RELIABILITY

Data reliability
description

 Antibody staining mainly consistent with RNA expression data.

Reliability score

 Supported based on 1 antibody.
HPA049512
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PROGNOSTIC SUMMARY
Prognostic marker in renal cancer (favourable).
Renal cancer p<0.001
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RNA EXPRESSION OVERVIEW
TCGA dataset
RNA cancer category: Expressed in all

PROTEIN EXPRESSION
Colorectal cancer
Breast cancer
Prostate cancer
Lung cancer
Liver cancer

STAINING SUMMARY
HPA049512

GENE INFORMATION

Gene name

 KLF3 (HGNC Symbol)

Synonyms

 BKLF

Description

 Kruppel-like factor 3 (basic) (HGNC Symbol)

Entrez gene summary

Chromosome

 4

Cytoband

 p14

Chromosome location (bp)

 38664196 - 38701042

Protein evidence

 Evidence at protein level (all genes)

Ensembl

 ENSG00000109787 (version 83.38)

Entrez gene

 51274

UniProt

 P57682 (UniProt - Evidence at protein level)

neXtProt

 NX_P57682

Antibodypedia

 KLF3 antibodies

PROTEIN BROWSER
KLF3-001
KLF3-002

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)
KLF3-001
ENSP00000261438
ENST00000261438
P57682 [Direct mapping]
Krueppel-like factor 3
A0A024R9T8 [Target identity:100%; Query identity:100%]
Kruppel-like factor 3 (Basic), isoform CRA_a
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Predicted intracellular proteins
Transcription factors
   Zinc-coordinating DNA-binding domains
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
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GO:0003677 [DNA binding]
GO:0003700 [transcription factor activity, sequence-specific DNA binding]
GO:0005515 [protein binding]
GO:0005634 [nucleus]
GO:0006351 [transcription, DNA-templated]
GO:0006355 [regulation of transcription, DNA-templated]
GO:0007275 [multicellular organismal development]
GO:0046872 [metal ion binding]
GO:1901653 [cellular response to peptide]
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 345 aa
38.8 kDa 		No 0
KLF3-002
ENSP00000421252
ENST00000514033
P57682 [Direct mapping]
Krueppel-like factor 3
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Predicted intracellular proteins
Transcription factors
   Zinc-coordinating DNA-binding domains
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0003677 [DNA binding]
GO:0003700 [transcription factor activity, sequence-specific DNA binding]
GO:0005515 [protein binding]
GO:0005634 [nucleus]
GO:0006351 [transcription, DNA-templated]
GO:0006355 [regulation of transcription, DNA-templated]
GO:0007275 [multicellular organismal development]
GO:0046872 [metal ion binding]
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 232 aa
25.4 kDa 		No 0

Contact

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.