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NCAPG

GENERAL INFORMATION

Gene name

 NCAPG

Gene description

 Non-SMC condensin I complex, subunit G

Protein class

 Predicted intracellular proteins

Predicted localization

 Intracellular

Number of transcripts

 2
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HUMAN PROTEIN ATLAS INFORMATION

RNA category
TCGA (cancer tissue):Mixed
HPA (cell line):Expressed in all
HPA (normal tissue):Mixed

Protein evidence

 Evidence at protein level

Protein expression
normal tissue

 Cytoplasmic expression in several different tissues.

ANTIBODY IHC RELIABILITY

Data reliability
description

 Presumed off target binding observed and disregarded. Pending external verification.

Reliability score

 Uncertain based on 1 antibody.
HPA039613
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PROGNOSTIC SUMMARY
Prognostic marker in liver cancer (unfavourable), pancreatic cancer (unfavourable) and endometrial cancer (unfavourable).
Liver cancer p<0.001
Pancreatic cancer p<0.001
Endometrial cancer p<0.001
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RNA EXPRESSION OVERVIEW
TCGA dataset
RNA cancer category: Mixed

PROTEIN EXPRESSION
Colorectal cancer
Breast cancer
Prostate cancer
Lung cancer

STAINING SUMMARY
HPA039613

GENE INFORMATION

Gene name

 NCAPG (HGNC Symbol)

Synonyms

 CAP-G, FLJ12450, hCAP-G, YCG1

Description

 Non-SMC condensin I complex, subunit G (HGNC Symbol)

Entrez gene summary

 This gene encodes a subunit of the condensin complex, which is responsible for the condensation and stabilization of chromosomes during mitosis and meiosis. Phosphorylation of the encoded protein activates the condensin complex. There are pseudogenes for this gene on chromosomes 8 and 15. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Aug 2012]

Chromosome

 4

Cytoband

 p15.31

Chromosome location (bp)

 17810902 - 17844862

Protein evidence

 Evidence at protein level (all genes)

Ensembl

 ENSG00000109805 (version 83.38)

Entrez gene

 64151

UniProt

 Q9BPX3 (UniProt - Evidence at protein level)

neXtProt

 NX_Q9BPX3

Antibodypedia

 NCAPG antibodies

PROTEIN BROWSER
NCAPG-001
NCAPG-005

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)
NCAPG-001
ENSP00000251496
ENST00000251496
Q9BPX3 [Direct mapping]
Condensin complex subunit 3
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   MEMSAT3 predicted membrane proteins
   THUMBUP predicted membrane proteins
Predicted intracellular proteins
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
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GO:0000278 [mitotic cell cycle]
GO:0000793 [condensed chromosome]
GO:0000796 [condensin complex]
GO:0005488 [binding]
GO:0005515 [protein binding]
GO:0005634 [nucleus]
GO:0005737 [cytoplasm]
GO:0005813 [centrosome]
GO:0005829 [cytosol]
GO:0007076 [mitotic chromosome condensation]
GO:0015629 [actin cytoskeleton]
GO:0016020 [membrane]
GO:0051301 [cell division]
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 1015 aa
114.3 kDa 		No 0
NCAPG-005
ENSP00000425625
ENST00000510063
H0Y9Z8 [Direct mapping]
Condensin complex subunit 3
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Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
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GO:0000796 [condensin complex]
GO:0005488 [binding]
GO:0005737 [cytoplasm]
GO:0007076 [mitotic chromosome condensation]
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 269 aa
30.3 kDa 		No 0

Contact

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.