Expression of DDX25 in cancer - Summary - The Human Protein Atlas

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DDX25

TISSUE

CELL

PATHOLOGY

PATHOLOGY ATLAS

GENE/PROTEIN

Antibody validation

Dictionary


Level of antibody staining/expression
	High Medium Low Not detected

GENERAL INFORMATION
Gene name	DDX25
Gene description	DEAD (Asp-Glu-Ala-Asp) box helicase 25
Protein class	Enzymes Plasma proteins Predicted intracellular proteins Predicted secreted proteins
Predicted localization	Intracellular,Secreted
Number of transcripts	4
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HUMAN PROTEIN ATLAS INFORMATION

RNA category

TCGA (cancer tissue):	Tissue enhanced (glioma)
HPA (cell line):	Cell line enhanced (NTERA-2, SCLC-21H)
HPA (normal tissue):	Group enriched (cerebral cortex, testis)

Protein evidence

Evidence at protein level

Protein expression
normal tissue

Cytoplasmic expression in hypothalamus, cerebral cortex, testis and seminal vesicle.

ANTIBODY IHC RELIABILITY
Data reliability description	Antibody staining mainly consistent with RNA expression data. Secreted protein, tissue location of RNA and protein might differ and correlation is complex.
Reliability score	Supported based on 1 antibody. HPA020137
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PROGNOSTIC SUMMARY
Gene product is not prognostic.
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RNA EXPRESSION OVERVIEW
TCGA dataset RNA cancer category: Tissue enhanced (glioma)

PROTEIN EXPRESSION

Colorectal cancer

Prostate cancer

STAINING SUMMARY

HPA020137

GENE INFORMATION
Gene name	DDX25 (HGNC Symbol)
Synonyms	GRTH
Description	DEAD (Asp-Glu-Ala-Asp) box helicase 25 (HGNC Symbol)
Entrez gene summary	DEAD box proteins, characterized by the conserved motif Asp-Glu-Ala-Asp (DEAD), are putative RNA helicases. They are implicated in a number of cellular processes involving alteration of RNA secondary structure, such as translation initiation, nuclear and mitochondrial splicing, and ribosome and spliceosome assembly. Based on their distribution patterns, some members of the DEAD box protein family are believed to be involved in embryogenesis, spermatogenesis, and cellular growth and division. This gene encodes a member of this family. The encoded protein is a gonadotropin-regulated and developmentally expressed testicular RNA helicase. It may serve to maintain testicular functions related to steroidogenesis and spermatogenesis. [provided by RefSeq, Jul 2008]
Chromosome	11
Cytoband	q24.2
Chromosome location (bp)	125903376 - 125928829
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000109832 (version 83.38)
Entrez gene	29118
UniProt	Q9UHL0 (UniProt - Evidence at protein level)
neXtProt	NX_Q9UHL0
Antibodypedia	DDX25 antibodies

PROTEIN BROWSER

DDX25-001	DDX25-003	DDX25-004	DDX25-005

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
DDX25-001 ENSP00000263576 ENST00000263576	Q9UHL0 [Direct mapping] ATP-dependent RNA helicase DDX25 Show all	Enzymes ENZYME proteins Hydrolases Predicted intracellular proteins Plasma proteins Protein evidence (Kim et al 2014) Show all	GO:0003676 [nucleic acid binding] GO:0003723 [RNA binding] GO:0004004 [ATP-dependent RNA helicase activity] GO:0005524 [ATP binding] GO:0005634 [nucleus] GO:0005737 [cytoplasm] GO:0006406 [mRNA export from nucleus] GO:0006417 [regulation of translation] GO:0007275 [multicellular organismal development] GO:0007286 [spermatid development] GO:0010501 [RNA secondary structure unwinding] GO:0033391 [chromatoid body] Show all	483 aa 54.7 kDa	No	0
DDX25-003 ENSP00000463333 ENST00000530414	J3QL17 [Direct mapping] ATP-dependent RNA helicase DDX25 Show all	Predicted secreted proteins Secreted proteins predicted by MDSEC Phobius predicted secreted proteins SPOCTOPUS predicted secreted proteins Show all	GO:0003676 [nucleic acid binding] GO:0004004 [ATP-dependent RNA helicase activity] GO:0005524 [ATP binding] GO:0005622 [intracellular] GO:0006406 [mRNA export from nucleus] GO:0010501 [RNA secondary structure unwinding] Show all	468 aa 52.8 kDa	Yes	0
DDX25-004 ENSP00000436087 ENST00000526875	E9PR46 [Direct mapping] ATP-dependent RNA helicase DDX25 Show all	Predicted intracellular proteins Show all	GO:0003676 [nucleic acid binding] GO:0004004 [ATP-dependent RNA helicase activity] GO:0005524 [ATP binding] GO:0005622 [intracellular] GO:0006406 [mRNA export from nucleus] GO:0010501 [RNA secondary structure unwinding] Show all	407 aa 46.4 kDa	No	0
DDX25-005 ENSP00000432800 ENST00000530129	H0YD26 [Direct mapping] ATP-dependent RNA helicase DDX25 Show all	Predicted intracellular proteins Show all	GO:0003676 [nucleic acid binding] GO:0004004 [ATP-dependent RNA helicase activity] GO:0005524 [ATP binding] GO:0005622 [intracellular] GO:0006406 [mRNA export from nucleus] GO:0010501 [RNA secondary structure unwinding] Show all	191 aa 21 kDa	No	0

Contact

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The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.