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HTATIP2

GENERAL INFORMATION

Gene name

 HTATIP2

Gene description

 HIV-1 Tat interactive protein 2, 30kDa

Protein class

 Predicted intracellular proteins
Predicted membrane proteins
Predicted secreted proteins

Predicted localization

 Intracellular,Membrane,Secreted

Number of transcripts

 8
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HUMAN PROTEIN ATLAS INFORMATION

RNA category
TCGA (cancer tissue):Expressed in all
HPA (cell line):Mixed
HPA (normal tissue):Expressed in all

Protein evidence

 Evidence at protein level

Protein expression
normal tissue

 General cytoplasmic expression. Most abundant in the gastrointestinal tract.

ANTIBODY IHC RELIABILITY

Data reliability
description

 Antibody staining mainly consistent with RNA expression data. Pending external verification.

Reliability score

 Approved based on 2 antibodies.
HPA006417 , HPA024321
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PROGNOSTIC SUMMARY
Prognostic marker in liver cancer (unfavourable), pancreatic cancer (unfavourable) and renal cancer (unfavourable).
Liver cancer p<0.001
Pancreatic cancer p<0.001
Renal cancer p<0.001
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RNA EXPRESSION OVERVIEW
TCGA dataset
RNA cancer category: Expressed in all

PROTEIN EXPRESSION
Colorectal cancer
Breast cancer
Prostate cancer
Lung cancer
Liver cancer

STAINING SUMMARY
HPA006417
HPA024321

GENE INFORMATION

Gene name

 HTATIP2 (HGNC Symbol)

Synonyms

 CC3, FLJ26963, SDR44U1, TIP30

Description

 HIV-1 Tat interactive protein 2, 30kDa (HGNC Symbol)

Entrez gene summary

Chromosome

 11

Cytoband

 p15.1

Chromosome location (bp)

 20363685 - 20383783

Protein evidence

 Evidence at protein level (all genes)

Ensembl

 ENSG00000109854 (version 83.38)

Entrez gene

 10553

UniProt

 Q9BUP3 (UniProt - Evidence at protein level)

neXtProt

 NX_Q9BUP3

Antibodypedia

 HTATIP2 antibodies

PROTEIN BROWSER
HTATIP2-001
HTATIP2-002
HTATIP2-003
HTATIP2-004
HTATIP2-005
HTATIP2-006
HTATIP2-007
HTATIP2-009

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)
HTATIP2-001
ENSP00000392985
ENST00000419348
Q9BUP3 [Direct mapping]
Oxidoreductase HTATIP2
Show all
   SPOCTOPUS predicted membrane proteins
Predicted secreted proteins
   Secreted proteins predicted by MDSEC
   SignalP predicted secreted proteins
   Phobius predicted secreted proteins
   SPOCTOPUS predicted secreted proteins
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0001525 [angiogenesis]
GO:0003713 [transcription coactivator activity]
GO:0005515 [protein binding]
GO:0005634 [nucleus]
GO:0005635 [nuclear envelope]
GO:0005737 [cytoplasm]
GO:0006357 [regulation of transcription from RNA polymerase II promoter]
GO:0006915 [apoptotic process]
GO:0016020 [membrane]
GO:0016032 [viral process]
GO:0016491 [oxidoreductase activity]
GO:0030154 [cell differentiation]
GO:0043066 [negative regulation of apoptotic process]
GO:0045765 [regulation of angiogenesis]
GO:0051170 [nuclear import]
GO:0055114 [oxidation-reduction process]
Show all
 276 aa
30.1 kDa 		Yes 0
HTATIP2-002
ENSP00000394259
ENST00000451739
Q9BUP3 [Direct mapping]
Oxidoreductase HTATIP2
Show all
   SPOCTOPUS predicted membrane proteins
Predicted intracellular proteins
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0001525 [angiogenesis]
GO:0003713 [transcription coactivator activity]
GO:0005515 [protein binding]
GO:0005634 [nucleus]
GO:0005635 [nuclear envelope]
GO:0005737 [cytoplasm]
GO:0006357 [regulation of transcription from RNA polymerase II promoter]
GO:0006915 [apoptotic process]
GO:0016020 [membrane]
GO:0016032 [viral process]
GO:0016491 [oxidoreductase activity]
GO:0030154 [cell differentiation]
GO:0043066 [negative regulation of apoptotic process]
GO:0045765 [regulation of angiogenesis]
GO:0051170 [nuclear import]
GO:0055114 [oxidation-reduction process]
Show all
 242 aa
27 kDa 		No 0
HTATIP2-003
ENSP00000387876
ENST00000443524
Q9BUP3 [Direct mapping]
Oxidoreductase HTATIP2
Show all
   SPOCTOPUS predicted membrane proteins
Predicted intracellular proteins
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0001525 [angiogenesis]
GO:0003713 [transcription coactivator activity]
GO:0005515 [protein binding]
GO:0005634 [nucleus]
GO:0005635 [nuclear envelope]
GO:0005737 [cytoplasm]
GO:0006357 [regulation of transcription from RNA polymerase II promoter]
GO:0006915 [apoptotic process]
GO:0016020 [membrane]
GO:0016032 [viral process]
GO:0016491 [oxidoreductase activity]
GO:0030154 [cell differentiation]
GO:0043066 [negative regulation of apoptotic process]
GO:0045765 [regulation of angiogenesis]
GO:0051170 [nuclear import]
GO:0055114 [oxidation-reduction process]
Show all
 242 aa
27 kDa 		No 0
HTATIP2-004
ENSP00000397752
ENST00000421577
Q9BUP3 [Direct mapping]
Oxidoreductase HTATIP2
Show all
   SPOCTOPUS predicted membrane proteins
Predicted intracellular proteins
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0001525 [angiogenesis]
GO:0003713 [transcription coactivator activity]
GO:0005515 [protein binding]
GO:0005634 [nucleus]
GO:0005635 [nuclear envelope]
GO:0005737 [cytoplasm]
GO:0006357 [regulation of transcription from RNA polymerase II promoter]
GO:0006915 [apoptotic process]
GO:0016020 [membrane]
GO:0016032 [viral process]
GO:0016491 [oxidoreductase activity]
GO:0030154 [cell differentiation]
GO:0043066 [negative regulation of apoptotic process]
GO:0045765 [regulation of angiogenesis]
GO:0051170 [nuclear import]
GO:0055114 [oxidation-reduction process]
Show all
 242 aa
27 kDa 		No 0
HTATIP2-005
ENSP00000432338
ENST00000532505
Q9BUP3 [Direct mapping]
Oxidoreductase HTATIP2
Show all
Predicted membrane proteins
   Prediction method-based
   Membrane proteins predicted by MDM
   MEMSAT3 predicted membrane proteins
   MEMSAT-SVM predicted membrane proteins
   Phobius predicted membrane proteins
   SCAMPI predicted membrane proteins
   SPOCTOPUS predicted membrane proteins
   THUMBUP predicted membrane proteins
   TMHMM predicted membrane proteins
   # TM segments-based
   1TM proteins predicted by MDM
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0001525 [angiogenesis]
GO:0003713 [transcription coactivator activity]
GO:0005515 [protein binding]
GO:0005634 [nucleus]
GO:0005635 [nuclear envelope]
GO:0005737 [cytoplasm]
GO:0006357 [regulation of transcription from RNA polymerase II promoter]
GO:0006915 [apoptotic process]
GO:0016020 [membrane]
GO:0016032 [viral process]
GO:0016491 [oxidoreductase activity]
GO:0030154 [cell differentiation]
GO:0043066 [negative regulation of apoptotic process]
GO:0045765 [regulation of angiogenesis]
GO:0051170 [nuclear import]
GO:0055114 [oxidation-reduction process]
Show all
 133 aa
14.9 kDa 		No 1
HTATIP2-006
ENSP00000436548
ENST00000530266
Q9BUP3 [Direct mapping]
Oxidoreductase HTATIP2
Show all
Predicted membrane proteins
   Prediction method-based
   Membrane proteins predicted by MDM
   MEMSAT3 predicted membrane proteins
   MEMSAT-SVM predicted membrane proteins
   Phobius predicted membrane proteins
   SCAMPI predicted membrane proteins
   SPOCTOPUS predicted membrane proteins
   THUMBUP predicted membrane proteins
   TMHMM predicted membrane proteins
   # TM segments-based
   1TM proteins predicted by MDM
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0001525 [angiogenesis]
GO:0003713 [transcription coactivator activity]
GO:0005515 [protein binding]
GO:0005634 [nucleus]
GO:0005635 [nuclear envelope]
GO:0005737 [cytoplasm]
GO:0006357 [regulation of transcription from RNA polymerase II promoter]
GO:0006915 [apoptotic process]
GO:0016020 [membrane]
GO:0016032 [viral process]
GO:0016491 [oxidoreductase activity]
GO:0030154 [cell differentiation]
GO:0043066 [negative regulation of apoptotic process]
GO:0045765 [regulation of angiogenesis]
GO:0051170 [nuclear import]
GO:0055114 [oxidation-reduction process]
Show all
 133 aa
14.9 kDa 		No 1
HTATIP2-007
ENSP00000432107
ENST00000532081
Q9BUP3 [Direct mapping]
Oxidoreductase HTATIP2
Show all
Predicted membrane proteins
   Prediction method-based
   Membrane proteins predicted by MDM
   MEMSAT3 predicted membrane proteins
   MEMSAT-SVM predicted membrane proteins
   Phobius predicted membrane proteins
   SCAMPI predicted membrane proteins
   SPOCTOPUS predicted membrane proteins
   THUMBUP predicted membrane proteins
   TMHMM predicted membrane proteins
   # TM segments-based
   1TM proteins predicted by MDM
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0001525 [angiogenesis]
GO:0003713 [transcription coactivator activity]
GO:0005515 [protein binding]
GO:0005634 [nucleus]
GO:0005635 [nuclear envelope]
GO:0005737 [cytoplasm]
GO:0006357 [regulation of transcription from RNA polymerase II promoter]
GO:0006915 [apoptotic process]
GO:0016020 [membrane]
GO:0016032 [viral process]
GO:0016491 [oxidoreductase activity]
GO:0030154 [cell differentiation]
GO:0043066 [negative regulation of apoptotic process]
GO:0045765 [regulation of angiogenesis]
GO:0051170 [nuclear import]
GO:0055114 [oxidation-reduction process]
Show all
 133 aa
14.9 kDa 		No 1
HTATIP2-009
ENSP00000436729
ENST00000531058
E9PI87 [Direct mapping]
Oxidoreductase HTATIP2
Show all
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0005737 [cytoplasm]
GO:0016620 [oxidoreductase activity, acting on the aldehyde or oxo group of donors, NAD or NADP as acceptor]
GO:0051287 [NAD binding]
GO:0055114 [oxidation-reduction process]
Show all
 196 aa
22 kDa 		No 0

Contact

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.