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CTSC

GENERAL INFORMATION

Gene name

 CTSC

Gene description

 Cathepsin C

Protein class

 Disease related genes
Enzymes
Plasma proteins
Potential drug targets
Predicted intracellular proteins
Predicted secreted proteins

Predicted localization

 Intracellular,Secreted

Number of transcripts

 5
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HUMAN PROTEIN ATLAS INFORMATION

RNA category
TCGA (cancer tissue):Expressed in all
HPA (cell line):Expressed in all
HPA (normal tissue):Expressed in all

Protein evidence

 Evidence at protein level

Protein expression
normal tissue

 General cytoplasmic expression with a granular a pattern.

ANTIBODY IHC RELIABILITY

Data reliability
description

 Antibody staining mainly consistent with RNA expression data.

Reliability score

 Supported based on 1 antibody.
CAB025364
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PROGNOSTIC SUMMARY
Prognostic marker in liver cancer (unfavourable) and renal cancer (favourable).
Liver cancer p<0.001
Renal cancer p<0.001
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RNA EXPRESSION OVERVIEW
TCGA dataset
RNA cancer category: Expressed in all

PROTEIN EXPRESSION
Colorectal cancer
Breast cancer
Prostate cancer
Lung cancer
Liver cancer

STAINING SUMMARY
CAB025364

GENE INFORMATION

Gene name

 CTSC (HGNC Symbol)

Synonyms

 DPP1, PALS, PLS

Description

 Cathepsin C (HGNC Symbol)

Entrez gene summary

 This gene encodes a member of the peptidase C1 family and lysosomal cysteine proteinase that appears to be a central coordinator for activation of many serine proteinases in cells of the immune system. Alternative splicing results in multiple transcript variants, at least one of which encodes a preproprotein that is proteolytically processed to generate heavy and light chains that form a disulfide-linked dimer. A portion of the propeptide acts as an intramolecular chaperone for the folding and stabilization of the mature enzyme. This enzyme requires chloride ions for activity and can degrade glucagon. Defects in the encoded protein have been shown to be a cause of Papillon-Lefevre syndrome, an autosomal recessive disorder characterized by palmoplantar keratosis and periodontitis. [provided by RefSeq, Nov 2015]

Chromosome

 11

Cytoband

 q14.2

Chromosome location (bp)

 88293592 - 88337787

Protein evidence

 Evidence at protein level (all genes)

Ensembl

 ENSG00000109861 (version 83.38)

Entrez gene

 1075

UniProt

 P53634 (UniProt - Evidence at protein level)

neXtProt

 NX_P53634

Antibodypedia

 CTSC antibodies

PROTEIN BROWSER
CTSC-001
CTSC-002
CTSC-003
CTSC-004
CTSC-009

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)
CTSC-001
ENSP00000227266
ENST00000227266
P53634 [Direct mapping]
Dipeptidyl peptidase 1 Dipeptidyl peptidase 1 exclusion domain chain Dipeptidyl peptidase 1 heavy chain Dipeptidyl peptidase 1 light chain
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Enzymes
   ENZYME proteins
   Hydrolases
   Peptidases
   Cysteine-type peptidases
Predicted secreted proteins
   Secreted proteins predicted by MDSEC
   SignalP predicted secreted proteins
   Phobius predicted secreted proteins
   SPOCTOPUS predicted secreted proteins
Plasma proteins
Disease related genes
Potential drug targets
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000139 [Golgi membrane]
GO:0001913 [T cell mediated cytotoxicity]
GO:0004197 [cysteine-type endopeptidase activity]
GO:0004252 [serine-type endopeptidase activity]
GO:0005515 [protein binding]
GO:0005615 [extracellular space]
GO:0005764 [lysosome]
GO:0005783 [endoplasmic reticulum]
GO:0005788 [endoplasmic reticulum lumen]
GO:0005794 [Golgi apparatus]
GO:0006508 [proteolysis]
GO:0006888 [ER to Golgi vesicle-mediated transport]
GO:0006915 [apoptotic process]
GO:0006919 [activation of cysteine-type endopeptidase activity involved in apoptotic process]
GO:0006955 [immune response]
GO:0007568 [aging]
GO:0008234 [cysteine-type peptidase activity]
GO:0008656 [cysteine-type endopeptidase activator activity involved in apoptotic process]
GO:0010033 [response to organic substance]
GO:0010952 [positive regulation of peptidase activity]
GO:0016020 [membrane]
GO:0016505 [peptidase activator activity involved in apoptotic process]
GO:0018279 [protein N-linked glycosylation via asparagine]
GO:0019902 [phosphatase binding]
GO:0030134 [ER to Golgi transport vesicle]
GO:0031404 [chloride ion binding]
GO:0033116 [endoplasmic reticulum-Golgi intermediate compartment membrane]
GO:0042802 [identical protein binding]
GO:0043621 [protein self-association]
GO:0043687 [post-translational protein modification]
GO:0044267 [cellular protein metabolic process]
GO:0048208 [COPII vesicle coating]
GO:0051087 [chaperone binding]
GO:0051603 [proteolysis involved in cellular protein catabolic process]
GO:0061024 [membrane organization]
GO:0070062 [extracellular exosome]
GO:1903052 [positive regulation of proteolysis involved in cellular protein catabolic process]
GO:2001235 [positive regulation of apoptotic signaling pathway]
Show all
 463 aa
51.9 kDa 		Yes 0
CTSC-002
ENSP00000432541
ENST00000524463
P53634 [Direct mapping]
Dipeptidyl peptidase 1 Dipeptidyl peptidase 1 exclusion domain chain Dipeptidyl peptidase 1 heavy chain Dipeptidyl peptidase 1 light chain
Show all
Enzymes
   ENZYME proteins
   Hydrolases
   Peptidases
   Cysteine-type peptidases
Predicted secreted proteins
   Secreted proteins predicted by MDSEC
   SignalP predicted secreted proteins
   Phobius predicted secreted proteins
   SPOCTOPUS predicted secreted proteins
Plasma proteins
Disease related genes
Potential drug targets
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000139 [Golgi membrane]
GO:0004197 [cysteine-type endopeptidase activity]
GO:0005515 [protein binding]
GO:0005615 [extracellular space]
GO:0005764 [lysosome]
GO:0005788 [endoplasmic reticulum lumen]
GO:0006508 [proteolysis]
GO:0006888 [ER to Golgi vesicle-mediated transport]
GO:0006919 [activation of cysteine-type endopeptidase activity involved in apoptotic process]
GO:0006955 [immune response]
GO:0008234 [cysteine-type peptidase activity]
GO:0008656 [cysteine-type endopeptidase activator activity involved in apoptotic process]
GO:0010952 [positive regulation of peptidase activity]
GO:0016020 [membrane]
GO:0018279 [protein N-linked glycosylation via asparagine]
GO:0019902 [phosphatase binding]
GO:0030134 [ER to Golgi transport vesicle]
GO:0033116 [endoplasmic reticulum-Golgi intermediate compartment membrane]
GO:0043687 [post-translational protein modification]
GO:0044267 [cellular protein metabolic process]
GO:0048208 [COPII vesicle coating]
GO:0051087 [chaperone binding]
GO:0051603 [proteolysis involved in cellular protein catabolic process]
GO:0061024 [membrane organization]
GO:0070062 [extracellular exosome]
GO:1903052 [positive regulation of proteolysis involved in cellular protein catabolic process]
GO:2001235 [positive regulation of apoptotic signaling pathway]
Show all
 137 aa
15.2 kDa 		Yes 0
CTSC-003
ENSP00000433539
ENST00000529974
P53634 [Direct mapping]
Dipeptidyl peptidase 1 Dipeptidyl peptidase 1 exclusion domain chain Dipeptidyl peptidase 1 heavy chain Dipeptidyl peptidase 1 light chain
Show all
Enzymes
   ENZYME proteins
   Hydrolases
   Peptidases
   Cysteine-type peptidases
Predicted secreted proteins
   Secreted proteins predicted by MDSEC
   SignalP predicted secreted proteins
   Phobius predicted secreted proteins
   SPOCTOPUS predicted secreted proteins
Plasma proteins
Disease related genes
Potential drug targets
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000139 [Golgi membrane]
GO:0004197 [cysteine-type endopeptidase activity]
GO:0005515 [protein binding]
GO:0005615 [extracellular space]
GO:0005764 [lysosome]
GO:0005788 [endoplasmic reticulum lumen]
GO:0006508 [proteolysis]
GO:0006888 [ER to Golgi vesicle-mediated transport]
GO:0006919 [activation of cysteine-type endopeptidase activity involved in apoptotic process]
GO:0006955 [immune response]
GO:0008234 [cysteine-type peptidase activity]
GO:0008656 [cysteine-type endopeptidase activator activity involved in apoptotic process]
GO:0010952 [positive regulation of peptidase activity]
GO:0016020 [membrane]
GO:0018279 [protein N-linked glycosylation via asparagine]
GO:0019902 [phosphatase binding]
GO:0030134 [ER to Golgi transport vesicle]
GO:0033116 [endoplasmic reticulum-Golgi intermediate compartment membrane]
GO:0043687 [post-translational protein modification]
GO:0044267 [cellular protein metabolic process]
GO:0048208 [COPII vesicle coating]
GO:0051087 [chaperone binding]
GO:0051603 [proteolysis involved in cellular protein catabolic process]
GO:0061024 [membrane organization]
GO:0070062 [extracellular exosome]
GO:1903052 [positive regulation of proteolysis involved in cellular protein catabolic process]
GO:2001235 [positive regulation of apoptotic signaling pathway]
Show all
 141 aa
15.7 kDa 		Yes 0
CTSC-004
ENSP00000432556
ENST00000527018
H0YCY8 [Direct mapping]
Dipeptidyl peptidase 1
Show all
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0004197 [cysteine-type endopeptidase activity]
GO:0006508 [proteolysis]
GO:0006919 [activation of cysteine-type endopeptidase activity involved in apoptotic process]
GO:0008234 [cysteine-type peptidase activity]
GO:0008656 [cysteine-type endopeptidase activator activity involved in apoptotic process]
GO:0010952 [positive regulation of peptidase activity]
GO:0051603 [proteolysis involved in cellular protein catabolic process]
GO:2001235 [positive regulation of apoptotic signaling pathway]
Show all
 245 aa
27.8 kDa 		No 0
CTSC-009
ENSP00000433229
ENST00000528020
H0YDA2 [Direct mapping]
Dipeptidyl peptidase 1
Show all
   Phobius predicted membrane proteins
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0004197 [cysteine-type endopeptidase activity]
GO:0006919 [activation of cysteine-type endopeptidase activity involved in apoptotic process]
GO:0008656 [cysteine-type endopeptidase activator activity involved in apoptotic process]
GO:0010952 [positive regulation of peptidase activity]
GO:0051603 [proteolysis involved in cellular protein catabolic process]
GO:2001235 [positive regulation of apoptotic signaling pathway]
Show all
 36 aa
4.1 kDa 		No 0

Contact

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.