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Lymphoma and a few prostate cancers displayed strong nuclear staining. Lung, stomach and pancreatic cancers displayed moderate to strong cytoplasmic staining. Most remaining cancer cells were weakly stained or negative.
Most cancer cells displayed moderate to strong cytoplasmic positivity with a granular pattern. Most lymphomas, breast, testicular and renal cancers were weakly stained or negative.
This gene encodes a component of the six subunit elongator complex, a histone acetyltransferase complex that associates directly with RNA polymerase II during transcriptional elongation. The human gene can partially complement sensitivity phenotypes of yeast ELP4 deletion mutants. This gene has also been associated with Rolandic epilepsy. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Dec 2013]
Q96EB1 [Direct mapping] Elongator complex protein 4
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MEMSAT3 predicted membrane proteins Phobius predicted secreted proteins Predicted intracellular proteins Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014)
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GO:0000123 [histone acetyltransferase complex] GO:0000993 [RNA polymerase II core binding] GO:0004402 [histone acetyltransferase activity] GO:0005515 [protein binding] GO:0005654 [nucleoplasm] GO:0005737 [cytoplasm] GO:0006325 [chromatin organization] GO:0006357 [regulation of transcription from RNA polymerase II promoter] GO:0006368 [transcription elongation from RNA polymerase II promoter] GO:0008023 [transcription elongation factor complex] GO:0008607 [phosphorylase kinase regulator activity] GO:0033588 [Elongator holoenzyme complex] GO:0043966 [histone H3 acetylation] GO:0043967 [histone H4 acetylation] GO:0045859 [regulation of protein kinase activity]