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Several cases of renal cancer showed moderate to strong nuclear and cytoplasmic positivity. A few melanomas, ovarian, cervical, colorectal, lung, testis and urothelial cancers showed weak to moderate cytoplasmic and/or nuclear positivity. Remaining cancer tissues were negative.
GENE INFORMATION
Gene name
P2RX3 (HGNC Symbol)
Synonyms
P2X3
Description
Purinergic receptor P2X, ligand gated ion channel, 3 (HGNC Symbol)
Entrez gene summary
The product of this gene belongs to the family of purinoceptors for ATP. This receptor functions as a ligand-gated ion channel and may transduce ATP-evoked nociceptor activation. Mouse studies suggest that this receptor is important for peripheral pain responses, and also participates in pathways controlling urinary bladder volume reflexes. It is possible that the development of selective antagonists for this receptor may have a therapeutic potential in pain relief and in the treatment of disorders of urine storage. [provided by RefSeq, Jul 2008]