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SIAE

GENERAL INFORMATION

Gene name

 SIAE

Gene description

 Sialic acid acetylesterase

Protein class

 Disease related genes
Enzymes
Potential drug targets
Predicted intracellular proteins
Predicted secreted proteins

Predicted localization

 Intracellular,Secreted

Number of transcripts

 3
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HUMAN PROTEIN ATLAS INFORMATION

RNA category
TCGA (cancer tissue):Expressed in all
HPA (cell line):Mixed
HPA (normal tissue):Expressed in all

Protein evidence

 Evidence at protein level

Protein expression
normal tissue

 Cytoplasmic expression in several tissues.

ANTIBODY IHC RELIABILITY

Data reliability
description

 Antibody staining mainly not consistent with RNA expression data. Pending external verification.

Reliability score

 Approved based on 2 antibodies.
HPA038052 , HPA038053
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PROGNOSTIC SUMMARY
Prognostic marker in renal cancer (favourable) and endometrial cancer (favourable).
Renal cancer p<0.001
Endometrial cancer p<0.001
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RNA EXPRESSION OVERVIEW
TCGA dataset
RNA cancer category: Expressed in all

PROTEIN EXPRESSION
Colorectal cancer
Breast cancer
Prostate cancer
Lung cancer
Liver cancer

STAINING SUMMARY
HPA038052
HPA038053

GENE INFORMATION

Gene name

 SIAE (HGNC Symbol)

Synonyms

 CSE-C, LSE, MGC87009, YSG2

Description

 Sialic acid acetylesterase (HGNC Symbol)

Entrez gene summary

 This gene encodes an enzyme which removes 9-O-acetylation modifications from sialic acids. Mutations in this gene are associated with susceptibility to autoimmune disease 6. Multiple transcript variants encoding different isoforms, found either in the cytosol or in the lysosome, have been found for this gene.[provided by RefSeq, Feb 2011]

Chromosome

 11

Cytoband

 q24.2

Chromosome location (bp)

 124633113 - 124695707

Protein evidence

 Evidence at protein level (all genes)

Ensembl

 ENSG00000110013 (version 83.38)

Entrez gene

 54414

UniProt

 Q9HAT2 (UniProt - Evidence at protein level)

neXtProt

 NX_Q9HAT2

Antibodypedia

 SIAE antibodies

PROTEIN BROWSER
SIAE-001
SIAE-005
SIAE-201

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)
SIAE-001
ENSP00000263593
ENST00000263593
Q9HAT2 [Direct mapping]
Sialate O-acetylesterase
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Enzymes
   ENZYME proteins
   Hydrolases
   MEMSAT3 predicted membrane proteins
Predicted secreted proteins
   Secreted proteins predicted by MDSEC
   SignalP predicted secreted proteins
   Phobius predicted secreted proteins
   SPOCTOPUS predicted secreted proteins
Disease related genes
Potential drug targets
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0001681 [sialate O-acetylesterase activity]
GO:0002682 [regulation of immune system process]
GO:0005615 [extracellular space]
GO:0005764 [lysosome]
GO:0005975 [carbohydrate metabolic process]
GO:0070062 [extracellular exosome]
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 523 aa
58.3 kDa 		Yes 0
SIAE-005
ENSP00000478211
ENST00000618733
Q9HAT2 [Direct mapping]
Sialate O-acetylesterase
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Enzymes
   ENZYME proteins
   Hydrolases
Predicted intracellular proteins
Disease related genes
Potential drug targets
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0001681 [sialate O-acetylesterase activity]
GO:0002682 [regulation of immune system process]
GO:0005615 [extracellular space]
GO:0005764 [lysosome]
GO:0005975 [carbohydrate metabolic process]
GO:0070062 [extracellular exosome]
Show all
 488 aa
54.6 kDa 		No 0
SIAE-201
ENSP00000437877
ENST00000545756
Q9HAT2 [Direct mapping]
Sialate O-acetylesterase
Show all
Enzymes
   ENZYME proteins
   Hydrolases
Predicted intracellular proteins
Disease related genes
Potential drug targets
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0001681 [sialate O-acetylesterase activity]
GO:0002682 [regulation of immune system process]
GO:0005615 [extracellular space]
GO:0005764 [lysosome]
GO:0005975 [carbohydrate metabolic process]
GO:0070062 [extracellular exosome]
Show all
 488 aa
54.6 kDa 		No 0

Contact

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.