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DTX4

GENERAL INFORMATION

Gene name

 DTX4

Gene description

 Deltex 4, E3 ubiquitin ligase

Protein class

 Predicted intracellular proteins

Predicted localization

 Intracellular

Number of transcripts

 2
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HUMAN PROTEIN ATLAS INFORMATION

RNA category
TCGA (cancer tissue):Expressed in all
HPA (cell line):Cell line enhanced (BEWO, RT4)
HPA (normal tissue):Mixed

Protein evidence

 Evidence at protein level

Protein expression
normal tissue

 Cytoplasmic expression in most tissues.

ANTIBODY IHC RELIABILITY

Data reliability
description

 Antibody staining mainly not consistent with RNA expression data. Pending external verification.

Reliability score

 Uncertain based on 2 antibodies.
HPA056760 , HPA059294
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PROGNOSTIC SUMMARY
Prognostic marker in thyroid cancer (favourable) and renal cancer (unfavourable).
Thyroid cancer p<0.001
Renal cancer p<0.001
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RNA EXPRESSION OVERVIEW
TCGA dataset
RNA cancer category: Expressed in all

PROTEIN EXPRESSION
Colorectal cancer
Breast cancer
Prostate cancer
Lung cancer

STAINING SUMMARY
HPA056760
HPA059294

GENE INFORMATION

Gene name

 DTX4 (HGNC Symbol)

Synonyms

 KIAA0937, RNF155

Description

 Deltex 4, E3 ubiquitin ligase (HGNC Symbol)

Entrez gene summary

Chromosome

 11

Cytoband

 q12.1

Chromosome location (bp)

 59171430 - 59208587

Protein evidence

 Evidence at protein level (all genes)

Ensembl

 ENSG00000110042 (version 83.38)

Entrez gene

 23220

UniProt

 Q9Y2E6 (UniProt - Evidence at protein level)

neXtProt

 NX_Q9Y2E6

Antibodypedia

 DTX4 antibodies

PROTEIN BROWSER
DTX4-001
DTX4-002

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)
DTX4-001
ENSP00000227451
ENST00000227451
Q9Y2E6 [Direct mapping]
E3 ubiquitin-protein ligase DTX4
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   SPOCTOPUS predicted membrane proteins
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
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GO:0005515 [protein binding]
GO:0005829 [cytosol]
GO:0007219 [Notch signaling pathway]
GO:0008270 [zinc ion binding]
GO:0016567 [protein ubiquitination]
GO:0016874 [ligase activity]
GO:0032479 [regulation of type I interferon production]
GO:0032481 [positive regulation of type I interferon production]
GO:0045087 [innate immune response]
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 619 aa
67.3 kDa 		No 0
DTX4-002
ENSP00000434055
ENST00000532982
Q9Y2E6 [Direct mapping]
E3 ubiquitin-protein ligase DTX4
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   SPOCTOPUS predicted membrane proteins
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0005515 [protein binding]
GO:0005829 [cytosol]
GO:0007219 [Notch signaling pathway]
GO:0008270 [zinc ion binding]
GO:0016567 [protein ubiquitination]
GO:0016874 [ligase activity]
GO:0032479 [regulation of type I interferon production]
GO:0032481 [positive regulation of type I interferon production]
GO:0045087 [innate immune response]
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 513 aa
55.3 kDa 		No 0

Contact

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.