Fields »
ABOUT
HELP
BLOG
PPP6R3

GENERAL INFORMATION

Gene name

 PPP6R3

Gene description

 Protein phosphatase 6, regulatory subunit 3

Protein class

 Predicted intracellular proteins

Predicted localization

 Intracellular

Number of transcripts

 16
SHOW MORE

HUMAN PROTEIN ATLAS INFORMATION

RNA tissue category
HPA:Expressed in all
GTEx:Expressed in all
FANTOM5:Expressed in all

Protein evidence

 Evidence at protein level

Protein expression

 Cytoplasmic and nuclear expression in most tissues.

DATA RELIABILITY

Data reliability
description

 Antibody staining mainly consistent with RNA expression data. Pending external verification.

Reliability score

 Supported based on 3 antibodies.
HPA038467 , HPA038468 , CAB017183
SHOW MORE

RNA AND PROTEIN EXPRESSION SUMMARY
RNA expression (TPM) Protein expression (score)
Brain
Caudate
N/A
Endocrine tissues
Bone marrow & immune system
Muscle tissues
Lung
Bronchus
N/A
Liver & gallbladder
Pancreas
Gastrointestinal tract
Kidney & urinary bladder
Male tissues
Female tissues
Vagina
N/A
Adipose & soft tissue
Skin
Cerebral cortex

Adrenal gland

Lymph node

Liver

Colon

Kidney

Testis

PROTEIN EXPRESSION OVERVIEW
Organ
Expression
Alphabetical

RNA EXPRESSION OVERVIEW
HPA dataset
Organ
Expression
Alphabetical
RNA tissue category: Expressed in all
GTEx dataset
Organ
Expression
Alphabetical
RNA tissue category: Expressed in all
FANTOM5 dataset
Organ
Expression
Alphabetical
RNA tissue category: Expressed in all

GENE INFORMATION

Gene name

 PPP6R3 (HGNC Symbol)

Synonyms

 C11orf23, DKFZp781E17107, DKFZp781E2374, DKFZp781O2362, FLJ11058, FLJ43065, KIAA1558, MGC125711, MGC125712, PP6R3, SAP190, SAPL, SAPLa, SAPS3

Description

 Protein phosphatase 6, regulatory subunit 3 (HGNC Symbol)

Entrez gene summary

 Protein phosphatase regulatory subunits, such as SAPS3, modulate the activity of protein phosphatase catalytic subunits by restricting substrate specificity, recruiting substrates, and determining the intracellular localization of the holoenzyme. SAPS3 is a regulatory subunit for the protein phosphatase-6 catalytic subunit (PPP6C; MIM 612725) (Stefansson and Brautigan, 2006 [PubMed 16769727]).[supplied by OMIM, Nov 2010]

Chromosome

 11

Cytoband

 q13.2

Chromosome location (bp)

 68460731 - 68615334

Protein evidence

 Evidence at protein level (all genes)

Ensembl

 ENSG00000110075 (version 83.38)

Entrez gene

 55291

UniProt

 Q5H9R7 (UniProt - Evidence at protein level)

neXtProt

 NX_Q5H9R7

Antibodypedia

 PPP6R3 antibodies

PROTEIN BROWSER
«
PPP6R3-001
PPP6R3-003
PPP6R3-004
PPP6R3-005
PPP6R3-007
PPP6R3-008
PPP6R3-009
PPP6R3-011
PPP6R3-012
PPP6R3-013
PPP6R3-018
PPP6R3-020
PPP6R3-021
PPP6R3-025
PPP6R3-026
PPP6R3-027
»

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)
PPP6R3-001
ENSP00000377389
ENST00000393800
Q5H9R7 [Direct mapping]
Serine/threonine-protein phosphatase 6 regulatory subunit 3
Show all
Predicted intracellular proteins
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000139 [Golgi membrane]
GO:0005488 [binding]
GO:0005515 [protein binding]
GO:0005654 [nucleoplasm]
GO:0005737 [cytoplasm]
GO:0005829 [cytosol]
GO:0005886 [plasma membrane]
GO:0006888 [ER to Golgi vesicle-mediated transport]
GO:0018279 [protein N-linked glycosylation via asparagine]
GO:0019903 [protein phosphatase binding]
GO:0043666 [regulation of phosphoprotein phosphatase activity]
GO:0043687 [post-translational protein modification]
GO:0044267 [cellular protein metabolic process]
GO:0048208 [COPII vesicle coating]
GO:0061024 [membrane organization]
Show all
 873 aa
97.7 kDa 		No 0
PPP6R3-003
ENSP00000265636
ENST00000265636
Q5H9R7 [Direct mapping]
Serine/threonine-protein phosphatase 6 regulatory subunit 3
A0A024R5F3 [Target identity:100%; Query identity:100%]
SAPS domain family, member 3, isoform CRA_c
Show all
Predicted intracellular proteins
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000139 [Golgi membrane]
GO:0005488 [binding]
GO:0005515 [protein binding]
GO:0005654 [nucleoplasm]
GO:0005737 [cytoplasm]
GO:0005829 [cytosol]
GO:0005886 [plasma membrane]
GO:0006888 [ER to Golgi vesicle-mediated transport]
GO:0018279 [protein N-linked glycosylation via asparagine]
GO:0019903 [protein phosphatase binding]
GO:0043666 [regulation of phosphoprotein phosphatase activity]
GO:0043687 [post-translational protein modification]
GO:0044267 [cellular protein metabolic process]
GO:0048208 [COPII vesicle coating]
GO:0061024 [membrane organization]
Show all
 793 aa
89 kDa 		No 0
PPP6R3-004
ENSP00000437329
ENST00000529710
Q5H9R7 [Direct mapping]
Serine/threonine-protein phosphatase 6 regulatory subunit 3
Show all
Predicted intracellular proteins
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000139 [Golgi membrane]
GO:0005488 [binding]
GO:0005515 [protein binding]
GO:0005654 [nucleoplasm]
GO:0005737 [cytoplasm]
GO:0005829 [cytosol]
GO:0005886 [plasma membrane]
GO:0006888 [ER to Golgi vesicle-mediated transport]
GO:0018279 [protein N-linked glycosylation via asparagine]
GO:0019903 [protein phosphatase binding]
GO:0043666 [regulation of phosphoprotein phosphatase activity]
GO:0043687 [post-translational protein modification]
GO:0044267 [cellular protein metabolic process]
GO:0048208 [COPII vesicle coating]
GO:0061024 [membrane organization]
Show all
 791 aa
88.9 kDa 		No 0
PPP6R3-005
ENSP00000377390
ENST00000393801
Q5H9R7 [Direct mapping]
Serine/threonine-protein phosphatase 6 regulatory subunit 3
Show all
Predicted intracellular proteins
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000139 [Golgi membrane]
GO:0005488 [binding]
GO:0005515 [protein binding]
GO:0005654 [nucleoplasm]
GO:0005737 [cytoplasm]
GO:0005829 [cytosol]
GO:0005886 [plasma membrane]
GO:0006888 [ER to Golgi vesicle-mediated transport]
GO:0018279 [protein N-linked glycosylation via asparagine]
GO:0019903 [protein phosphatase binding]
GO:0043666 [regulation of phosphoprotein phosphatase activity]
GO:0043687 [post-translational protein modification]
GO:0044267 [cellular protein metabolic process]
GO:0048208 [COPII vesicle coating]
GO:0061024 [membrane organization]
Show all
 879 aa
98.5 kDa 		No 0
PPP6R3-007
ENSP00000433058
ENST00000524904
Q5H9R7 [Direct mapping]
Serine/threonine-protein phosphatase 6 regulatory subunit 3
Show all
Predicted intracellular proteins
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000139 [Golgi membrane]
GO:0005488 [binding]
GO:0005515 [protein binding]
GO:0005654 [nucleoplasm]
GO:0005737 [cytoplasm]
GO:0005829 [cytosol]
GO:0005886 [plasma membrane]
GO:0006888 [ER to Golgi vesicle-mediated transport]
GO:0018279 [protein N-linked glycosylation via asparagine]
GO:0019903 [protein phosphatase binding]
GO:0043666 [regulation of phosphoprotein phosphatase activity]
GO:0043687 [post-translational protein modification]
GO:0044267 [cellular protein metabolic process]
GO:0048208 [COPII vesicle coating]
GO:0061024 [membrane organization]
Show all
 867 aa
97 kDa 		No 0
PPP6R3-008
ENSP00000434429
ENST00000534534
E9PQP7 [Direct mapping]
Serine/threonine-protein phosphatase 6 regulatory subunit 3
Show all
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0005654 [nucleoplasm]
GO:0005737 [cytoplasm]
GO:0005886 [plasma membrane]
Show all
 641 aa
70.8 kDa 		No 0
PPP6R3-009
ENSP00000431738
ENST00000529907
E9PK08 [Direct mapping]
Serine/threonine-protein phosphatase 6 regulatory subunit 3
Show all
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
 140 aa
16.3 kDa 		No 0
PPP6R3-011
ENSP00000433551
ENST00000529344
E9PKG4 [Direct mapping]
Serine/threonine-protein phosphatase 6 regulatory subunit 3
Show all
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
 75 aa
9 kDa 		No 0
PPP6R3-012
ENSP00000436789
ENST00000528635
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0005737 [cytoplasm]
GO:0006516 [glycoprotein catabolic process]
Show all
 8 aa
1.1 kDa 		No 0
PPP6R3-013
ENSP00000432837
ENST00000531244
E9PNN8 [Direct mapping]
Serine/threonine-protein phosphatase 6 regulatory subunit 3
Show all
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
 186 aa
21.8 kDa 		No 0
PPP6R3-018
ENSP00000436209
ENST00000534190
H0YEN2 [Direct mapping]
Serine/threonine-protein phosphatase 6 regulatory subunit 3
Show all
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0005654 [nucleoplasm]
GO:0005737 [cytoplasm]
GO:0005886 [plasma membrane]
Show all
 580 aa
63.8 kDa 		No 0
PPP6R3-020
ENSP00000433565
ENST00000527403
E9PKF6 [Direct mapping]
Serine/threonine-protein phosphatase 6 regulatory subunit 3
Show all
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0005488 [binding]
GO:0005654 [nucleoplasm]
GO:0005737 [cytoplasm]
GO:0005886 [plasma membrane]
Show all
 838 aa
93.7 kDa 		No 0
PPP6R3-021
ENSP00000265637
ENST00000265637
H7BXH2 [Direct mapping]
Serine/threonine-protein phosphatase 6 regulatory subunit 3
Show all
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0005488 [binding]
GO:0005654 [nucleoplasm]
GO:0005737 [cytoplasm]
GO:0005886 [plasma membrane]
Show all
 827 aa
92.4 kDa 		No 0
PPP6R3-025
ENSP00000433853
ENST00000530734
H0YDK9 [Direct mapping]
Serine/threonine-protein phosphatase 6 regulatory subunit 3
Show all
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
 51 aa
5 kDa 		No 0
PPP6R3-026
ENSP00000431415
ENST00000524845
Q5H9R7 [Direct mapping]
Serine/threonine-protein phosphatase 6 regulatory subunit 3
Show all
Predicted intracellular proteins
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000139 [Golgi membrane]
GO:0005488 [binding]
GO:0005515 [protein binding]
GO:0005654 [nucleoplasm]
GO:0005737 [cytoplasm]
GO:0005829 [cytosol]
GO:0005886 [plasma membrane]
GO:0006888 [ER to Golgi vesicle-mediated transport]
GO:0018279 [protein N-linked glycosylation via asparagine]
GO:0019903 [protein phosphatase binding]
GO:0043666 [regulation of phosphoprotein phosphatase activity]
GO:0043687 [post-translational protein modification]
GO:0044267 [cellular protein metabolic process]
GO:0048208 [COPII vesicle coating]
GO:0061024 [membrane organization]
Show all
 844 aa
94.4 kDa 		No 0
PPP6R3-027
ENSP00000433768
ENST00000533127
E9PJD8 [Direct mapping]
Serine/threonine-protein phosphatase 6 regulatory subunit 3
Show all
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
 39 aa
4.7 kDa 		No 0

Contact

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.