Expression of CCDC86 in cancer - Summary - The Human Protein Atlas

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CCDC86

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TISSUE

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CELL

PATHOLOGY

PATHOLOGY ATLAS

GENE/PROTEIN

Antibody validation

Dictionary


Level of antibody staining/expression
	High Medium Low Not detected

GENERAL INFORMATION
Gene name	CCDC86
Gene description	Coiled-coil domain containing 86
Protein class	Predicted intracellular proteins
Predicted localization	Intracellular
Number of transcripts	2
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HUMAN PROTEIN ATLAS INFORMATION

RNA category

TCGA (cancer tissue):	Expressed in all
HPA (cell line):	Expressed in all
HPA (normal tissue):	Tissue enriched (parathyroid gland)

Protein evidence

Evidence at protein level

Protein expression
normal tissue

General nuclear and nucleolar expression.

ANTIBODY IHC RELIABILITY
Data reliability description	Antibody staining mainly consistent with RNA expression data.
Reliability score	Supported based on 2 antibodies. HPA041117 , HPA041540
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PROGNOSTIC SUMMARY
Prognostic marker in head and neck cancer (unfavourable) and liver cancer (unfavourable).
Head and neck cancer p<0.001 Liver cancer p<0.001 Show all

RNA EXPRESSION OVERVIEW
TCGA dataset RNA cancer category: Expressed in all

PROTEIN EXPRESSION

Colorectal cancer

Prostate cancer

STAINING SUMMARY

HPA041117	HPA041540

GENE INFORMATION
Gene name	CCDC86 (HGNC Symbol)
Synonyms	MGC2574
Description	Coiled-coil domain containing 86 (HGNC Symbol)
Entrez gene summary
Chromosome	11
Cytoband	q12.2
Chromosome location (bp)	60842071 - 60851081
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000110104 (version 83.38)
Entrez gene	79080
UniProt	Q9H6F5 (UniProt - Evidence at protein level)
neXtProt	NX_Q9H6F5
Antibodypedia	CCDC86 antibodies

PROTEIN BROWSER

CCDC86-001	CCDC86-005

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
CCDC86-001 ENSP00000227520 ENST00000227520	Q9H6F5 [Direct mapping] Coiled-coil domain-containing protein 86 Show all	Predicted intracellular proteins Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0005515 [protein binding] GO:0005634 [nucleus] GO:0005654 [nucleoplasm] GO:0005730 [nucleolus] GO:0016032 [viral process] GO:0044822 [poly(A) RNA binding] Show all	360 aa 40.2 kDa	No	0
CCDC86-005 ENSP00000440906 ENST00000545580	Q9H6F5 [Direct mapping] Coiled-coil domain-containing protein 86 Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0005515 [protein binding] GO:0005634 [nucleus] GO:0005654 [nucleoplasm] GO:0005730 [nucleolus] GO:0016032 [viral process] GO:0044822 [poly(A) RNA binding] Show all	104 aa 12.7 kDa	No	0

Contact

contact@proteinatlas.org

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.