Expression of TMEM109 in cancer - Summary

GENERAL INFORMATION
Gene name	TMEM109
Gene description	Transmembrane protein 109
Protein class	Predicted membrane proteins Transporters
Predicted localization	Membrane
Number of transcripts	2
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HUMAN PROTEIN ATLAS INFORMATION

RNA category

TCGA (cancer tissue):	Expressed in all
HPA (cell line):	Expressed in all
HPA (normal tissue):	Expressed in all

Protein evidence

Evidence at protein level

Protein expression
normal tissue

General cytoplasmic expression, including additional nuclear membranous expression in several tissues.

ANTIBODY IHC RELIABILITY
Data reliability description	Antibody staining mainly consistent with RNA expression data. Pending external verification.
Reliability score	Approved based on 1 antibody. HPA011785
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PROGNOSTIC SUMMARY
Prognostic marker in urothelial cancer (unfavourable).
Urothelial cancer p<0.001 Show all

RNA EXPRESSION OVERVIEW
TCGA dataset RNA cancer category: Expressed in all

PROTEIN EXPRESSION

STAINING SUMMARY

HPA011785

GENE INFORMATION
Gene name	TMEM109 (HGNC Symbol)
Synonyms	MGC5508
Description	Transmembrane protein 109 (HGNC Symbol)
Entrez gene summary
Chromosome	11
Cytoband	q12.2
Chromosome location (bp)	60913874 - 60923443
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000110108 (version 83.38)
Entrez gene	79073
UniProt	Q9BVC6 (UniProt - Evidence at protein level)
neXtProt	NX_Q9BVC6
Antibodypedia	TMEM109 antibodies

PROTEIN BROWSER

TMEM109-001	TMEM109-003

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
TMEM109-001 ENSP00000227525 ENST00000227525	Q9BVC6 [Direct mapping] Transmembrane protein 109 Show all	Transporters Transporter channels and pores Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 4TM proteins predicted by MDM Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0003674 [molecular_function] GO:0005244 [voltage-gated ion channel activity] GO:0005515 [protein binding] GO:0005640 [nuclear outer membrane] GO:0006811 [ion transport] GO:0016021 [integral component of membrane] GO:0033017 [sarcoplasmic reticulum membrane] GO:0034765 [regulation of ion transmembrane transport] GO:0042771 [intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator] GO:0060548 [negative regulation of cell death] GO:0070062 [extracellular exosome] GO:0071480 [cellular response to gamma radiation] Show all	243 aa 26.2 kDa	Yes	4
TMEM109-003 ENSP00000443990 ENST00000536171	Q9BVC6 [Direct mapping] Transmembrane protein 109 Show all	Transporters Transporter channels and pores Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 4TM proteins predicted by MDM Protein evidence (Ezkurdia et al 2014) Show all	GO:0003674 [molecular_function] GO:0005244 [voltage-gated ion channel activity] GO:0005640 [nuclear outer membrane] GO:0006811 [ion transport] GO:0016021 [integral component of membrane] GO:0033017 [sarcoplasmic reticulum membrane] GO:0034765 [regulation of ion transmembrane transport] GO:0060548 [negative regulation of cell death] GO:0070062 [extracellular exosome] GO:0071480 [cellular response to gamma radiation] Show all	243 aa 26.2 kDa	Yes	4