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Field

Term
Gene name

Class

Subclass

Chromosome

External id

In atlas

Reliability

Reliability

Reliability

Validation

Method

Validation

Method

Validation

Method

Validation

Location

Searches

Tissue

Cell type

Expression

Tissue

Specificity

Cell line

Specificity

Cancer

Specificity

Tissue

Detectable

Cell line

Detectable

Cancer

Detectable

Cancer

Prognosis

Category

Score

Score

Score

Antibodies

Column

 
 
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HPX
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    TISSUE

  • CELL

  • PATHOLOGY

PATHOLOGY ATLAS

GENE/PROTEIN

Antibody validation

Dictionary

Level of antibody staining/expression





High
Medium
Low
Not detected

GENERAL INFORMATION

Gene name

HPX

Gene description

Hemopexin

Protein class

Candidate cardiovascular disease genes
Plasma proteins
Predicted secreted proteins

Predicted localization

Secreted

Number of transcripts

2
SHOW MORE

HUMAN PROTEIN ATLAS INFORMATION

RNA category

TCGA (cancer tissue):Tissue enriched (liver cancer)
HPA (cell line):Cell line enriched (Hep G2)
HPA (normal tissue):Tissue enriched (liver)

Protein evidence

Evidence at protein level

Protein expression
normal tissue

Positivity in plasma.

ANTIBODY IHC RELIABILITY

Data reliability
description

Secreted protein, tissue location of RNA and protein might differ and correlation is complex. Presumed off target binding observed and disregarded.

Reliability score

Supported based on 1 antibody.
CAB016725
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PROGNOSTIC SUMMARY

Prognostic marker in liver cancer (favourable).
Liver cancer p<0.001
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RNA EXPRESSION OVERVIEW

TCGA dataset
RNA cancer category: Tissue enriched (liver cancer)

PROTEIN EXPRESSION

Colorectal cancer
Breast cancer
Prostate cancer
Lung cancer
Liver cancer

STAINING SUMMARY

CAB016725

Cancer

Cancer staining

Protein
expression of
normal tissue

Breast cancer
 
Carcinoid
 
Cervical cancer
 
 
Colorectal cancer
 
 
Endometrial cancer
 
 
Glioma
 
Head and neck cancer
 
 
Liver cancer
 
 
Lung cancer
 
 
Lymphoma
 
 
 

Cancer

Cancer staining

Protein
expression of
normal tissue

Melanoma
 
Ovarian cancer
 
Pancreatic cancer
 
Prostate cancer
 
Renal cancer
 
Skin cancer
 
Stomach cancer
 
 
Testis cancer
 
Thyroid cancer
 
Urothelial cancer
 

Staining summary

Most malignancies were negative.

GENE INFORMATION

Gene name

HPX

Synonyms

Description

Hemopexin (HGNC Symbol)

Entrez gene summary

This gene encodes a plasma glycoprotein that binds heme with high affinity. The encoded protein is an acute phase protein that transports heme from the plasma to the liver and may be involved in protecting cells from oxidative stress. [provided by RefSeq, Apr 2009]

Chromosome

11

Cytoband

p15.4

Chromosome location (bp)

6431049 - 6442617

Protein evidence

Evidence at protein level (all genes)

Ensembl

ENSG00000110169 (version 83.38)

Entrez gene

3263

UniProt

P02790 (UniProt - Evidence at protein level)

neXtProt

NX_P02790

Antibodypedia

HPX antibodies

PROTEIN BROWSER

HPX-001
HPX-201

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)

HPX-001
ENSP00000265983
ENST00000265983
P02790 [Direct mapping]
Hemopexin
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   MEMSAT3 predicted membrane proteins
Predicted secreted proteins
   Secreted proteins predicted by MDSEC
   SignalP predicted secreted proteins
   Phobius predicted secreted proteins
   SPOCTOPUS predicted secreted proteins
Plasma proteins
Candidate cardiovascular disease genes
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0002639 [positive regulation of immunoglobulin production]
GO:0002925 [positive regulation of humoral immune response mediated by circulating immunoglobulin]
GO:0005515 [protein binding]
GO:0005576 [extracellular region]
GO:0005615 [extracellular space]
GO:0006879 [cellular iron ion homeostasis]
GO:0006898 [receptor-mediated endocytosis]
GO:0015232 [heme transporter activity]
GO:0015886 [heme transport]
GO:0016032 [viral process]
GO:0020027 [hemoglobin metabolic process]
GO:0042168 [heme metabolic process]
GO:0042511 [positive regulation of tyrosine phosphorylation of Stat1 protein]
GO:0046872 [metal ion binding]
GO:0051246 [regulation of protein metabolic process]
GO:0060332 [positive regulation of response to interferon-gamma]
GO:0060335 [positive regulation of interferon-gamma-mediated signaling pathway]
GO:0070062 [extracellular exosome]
GO:0071682 [endocytic vesicle lumen]
GO:0072562 [blood microparticle]
Show all
462 aa
51.7 kDa
Yes 0
HPX-201
ENSP00000479146
ENST00000615166
Q9BS19 [Direct mapping]
HPX protein; Hemopexin
Show all
   MEMSAT3 predicted membrane proteins
Predicted secreted proteins
   Secreted proteins predicted by MDSEC
   SignalP predicted secreted proteins
   Phobius predicted secreted proteins
   SPOCTOPUS predicted secreted proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0046872 [metal ion binding]
Show all
254 aa
28.6 kDa
Yes 0

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