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FOLR1

GENERAL INFORMATION

Gene name

 FOLR1

Gene description

 Folate receptor 1 (adult)

Protein class

 Disease related genes
Potential drug targets
Predicted membrane proteins
Transporters

Predicted localization

 Membrane

Number of transcripts

 4
SHOW MORE

HUMAN PROTEIN ATLAS INFORMATION

RNA category
TCGA (cancer tissue):Tissue enhanced (ovarian cancer)
HPA (cell line):Group enriched (HeLa, RPTEC TERT1)
HPA (normal tissue):Tissue enhanced (cervix, uterine, fallopian tube, lung)

Protein evidence

 Evidence at protein level

ANTIBODY IHC RELIABILITY

Reliability score

 Pending cancer tissue analysis.

PROGNOSTIC SUMMARY
Prognostic marker in liver cancer (unfavourable).
Liver cancer p<0.001
Show all

RNA EXPRESSION OVERVIEW
TCGA dataset
RNA cancer category: Tissue enhanced (ovarian cancer)

PROTEIN EXPRESSION

Pending cancer tissue analysis

STAINING SUMMARY

 

GENE INFORMATION

Gene name

 FOLR1 (HGNC Symbol)

Synonyms

 FOLR

Description

 Folate receptor 1 (adult) (HGNC Symbol)

Entrez gene summary

 The protein encoded by this gene is a member of the folate receptor family. Members of this gene family bind folic acid and its reduced derivatives, and transport 5-methyltetrahydrofolate into cells. This gene product is a secreted protein that either anchors to membranes via a glycosyl-phosphatidylinositol linkage or exists in a soluble form. Mutations in this gene have been associated with neurodegeneration due to cerebral folate transport deficiency. Due to the presence of two promoters, multiple transcription start sites, and alternative splicing, multiple transcript variants encoding the same protein have been found for this gene. [provided by RefSeq, Oct 2009]

Chromosome

 11

Cytoband

 q13.4

Chromosome location (bp)

 72189558 - 72196301

Protein evidence

 Evidence at protein level (all genes)

Ensembl

 ENSG00000110195 (version 83.38)

Entrez gene

 2348

UniProt

 P15328 (UniProt - Evidence at protein level)

neXtProt

 NX_P15328

Antibodypedia

 FOLR1 antibodies

PROTEIN BROWSER
FOLR1-001
FOLR1-002
FOLR1-003
FOLR1-004

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)
FOLR1-001
ENSP00000308137
ENST00000312293
P15328 [Direct mapping]
Folate receptor alpha
A0A024R5H1 [Target identity:100%; Query identity:100%]
Folate receptor 1 (Adult), isoform CRA_a
Show all
Transporters
Predicted membrane proteins
   Prediction method-based
   Membrane proteins predicted by MDM
   MEMSAT3 predicted membrane proteins
   MEMSAT-SVM predicted membrane proteins
   Phobius predicted membrane proteins
   SCAMPI predicted membrane proteins
   SPOCTOPUS predicted membrane proteins
   THUMBUP predicted membrane proteins
   TMHMM predicted membrane proteins
   # TM segments-based
   1TM proteins predicted by MDM
Disease related genes
Potential drug targets
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000139 [Golgi membrane]
GO:0001947 [heart looping]
GO:0003147 [neural crest cell migration involved in heart formation]
GO:0003253 [cardiac neural crest cell migration involved in outflow tract morphogenesis]
GO:0004872 [receptor activity]
GO:0005542 [folic acid binding]
GO:0005634 [nucleus]
GO:0005768 [endosome]
GO:0005789 [endoplasmic reticulum membrane]
GO:0005886 [plasma membrane]
GO:0005887 [integral component of plasma membrane]
GO:0006888 [ER to Golgi vesicle-mediated transport]
GO:0006898 [receptor-mediated endocytosis]
GO:0008144 [drug binding]
GO:0008517 [folic acid transporter activity]
GO:0009986 [cell surface]
GO:0012507 [ER to Golgi transport vesicle membrane]
GO:0015884 [folic acid transport]
GO:0016020 [membrane]
GO:0016323 [basolateral plasma membrane]
GO:0016324 [apical plasma membrane]
GO:0017015 [regulation of transforming growth factor beta receptor signaling pathway]
GO:0018279 [protein N-linked glycosylation via asparagine]
GO:0030136 [clathrin-coated vesicle]
GO:0031103 [axon regeneration]
GO:0031362 [anchored component of external side of plasma membrane]
GO:0033116 [endoplasmic reticulum-Golgi intermediate compartment membrane]
GO:0043687 [post-translational protein modification]
GO:0044267 [cellular protein metabolic process]
GO:0048208 [COPII vesicle coating]
GO:0051870 [methotrexate binding]
GO:0060828 [regulation of canonical Wnt signaling pathway]
GO:0061024 [membrane organization]
GO:0061626 [pharyngeal arch artery morphogenesis]
GO:0061713 [anterior neural tube closure]
GO:0070062 [extracellular exosome]
GO:0071231 [cellular response to folic acid]
Show all
 257 aa
29.8 kDa 		Yes 1
FOLR1-002
ENSP00000377286
ENST00000393681
P15328 [Direct mapping]
Folate receptor alpha
A0A024R5H1 [Target identity:100%; Query identity:100%]
Folate receptor 1 (Adult), isoform CRA_a
Show all
Transporters
Predicted membrane proteins
   Prediction method-based
   Membrane proteins predicted by MDM
   MEMSAT3 predicted membrane proteins
   MEMSAT-SVM predicted membrane proteins
   Phobius predicted membrane proteins
   SCAMPI predicted membrane proteins
   SPOCTOPUS predicted membrane proteins
   THUMBUP predicted membrane proteins
   TMHMM predicted membrane proteins
   # TM segments-based
   1TM proteins predicted by MDM
Disease related genes
Potential drug targets
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000139 [Golgi membrane]
GO:0001947 [heart looping]
GO:0003147 [neural crest cell migration involved in heart formation]
GO:0003253 [cardiac neural crest cell migration involved in outflow tract morphogenesis]
GO:0004872 [receptor activity]
GO:0005542 [folic acid binding]
GO:0005634 [nucleus]
GO:0005768 [endosome]
GO:0005789 [endoplasmic reticulum membrane]
GO:0005886 [plasma membrane]
GO:0005887 [integral component of plasma membrane]
GO:0006888 [ER to Golgi vesicle-mediated transport]
GO:0006898 [receptor-mediated endocytosis]
GO:0008144 [drug binding]
GO:0008517 [folic acid transporter activity]
GO:0009986 [cell surface]
GO:0012507 [ER to Golgi transport vesicle membrane]
GO:0015884 [folic acid transport]
GO:0016020 [membrane]
GO:0016323 [basolateral plasma membrane]
GO:0016324 [apical plasma membrane]
GO:0017015 [regulation of transforming growth factor beta receptor signaling pathway]
GO:0018279 [protein N-linked glycosylation via asparagine]
GO:0030136 [clathrin-coated vesicle]
GO:0031103 [axon regeneration]
GO:0031362 [anchored component of external side of plasma membrane]
GO:0033116 [endoplasmic reticulum-Golgi intermediate compartment membrane]
GO:0043687 [post-translational protein modification]
GO:0044267 [cellular protein metabolic process]
GO:0048208 [COPII vesicle coating]
GO:0051870 [methotrexate binding]
GO:0060828 [regulation of canonical Wnt signaling pathway]
GO:0061024 [membrane organization]
GO:0061626 [pharyngeal arch artery morphogenesis]
GO:0061713 [anterior neural tube closure]
GO:0070062 [extracellular exosome]
GO:0071231 [cellular response to folic acid]
Show all
 257 aa
29.8 kDa 		Yes 1
FOLR1-003
ENSP00000377284
ENST00000393679
P15328 [Direct mapping]
Folate receptor alpha
A0A024R5H1 [Target identity:100%; Query identity:100%]
Folate receptor 1 (Adult), isoform CRA_a
Show all
Transporters
Predicted membrane proteins
   Prediction method-based
   Membrane proteins predicted by MDM
   MEMSAT3 predicted membrane proteins
   MEMSAT-SVM predicted membrane proteins
   Phobius predicted membrane proteins
   SCAMPI predicted membrane proteins
   SPOCTOPUS predicted membrane proteins
   THUMBUP predicted membrane proteins
   TMHMM predicted membrane proteins
   # TM segments-based
   1TM proteins predicted by MDM
Disease related genes
Potential drug targets
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000139 [Golgi membrane]
GO:0001947 [heart looping]
GO:0003147 [neural crest cell migration involved in heart formation]
GO:0003253 [cardiac neural crest cell migration involved in outflow tract morphogenesis]
GO:0004872 [receptor activity]
GO:0005542 [folic acid binding]
GO:0005634 [nucleus]
GO:0005768 [endosome]
GO:0005789 [endoplasmic reticulum membrane]
GO:0005886 [plasma membrane]
GO:0005887 [integral component of plasma membrane]
GO:0005903 [brush border]
GO:0006888 [ER to Golgi vesicle-mediated transport]
GO:0006898 [receptor-mediated endocytosis]
GO:0008144 [drug binding]
GO:0008517 [folic acid transporter activity]
GO:0009986 [cell surface]
GO:0012507 [ER to Golgi transport vesicle membrane]
GO:0015884 [folic acid transport]
GO:0016020 [membrane]
GO:0016323 [basolateral plasma membrane]
GO:0016324 [apical plasma membrane]
GO:0017015 [regulation of transforming growth factor beta receptor signaling pathway]
GO:0018279 [protein N-linked glycosylation via asparagine]
GO:0030136 [clathrin-coated vesicle]
GO:0031103 [axon regeneration]
GO:0031362 [anchored component of external side of plasma membrane]
GO:0031526 [brush border membrane]
GO:0033116 [endoplasmic reticulum-Golgi intermediate compartment membrane]
GO:0043687 [post-translational protein modification]
GO:0044267 [cellular protein metabolic process]
GO:0046655 [folic acid metabolic process]
GO:0046658 [anchored component of plasma membrane]
GO:0048208 [COPII vesicle coating]
GO:0048678 [response to axon injury]
GO:0051870 [methotrexate binding]
GO:0060828 [regulation of canonical Wnt signaling pathway]
GO:0061024 [membrane organization]
GO:0061626 [pharyngeal arch artery morphogenesis]
GO:0061713 [anterior neural tube closure]
GO:0070062 [extracellular exosome]
GO:0071231 [cellular response to folic acid]
Show all
 257 aa
29.8 kDa 		Yes 1
FOLR1-004
ENSP00000377281
ENST00000393676
P15328 [Direct mapping]
Folate receptor alpha
A0A024R5H1 [Target identity:100%; Query identity:100%]
Folate receptor 1 (Adult), isoform CRA_a
Show all
Transporters
Predicted membrane proteins
   Prediction method-based
   Membrane proteins predicted by MDM
   MEMSAT3 predicted membrane proteins
   MEMSAT-SVM predicted membrane proteins
   Phobius predicted membrane proteins
   SCAMPI predicted membrane proteins
   SPOCTOPUS predicted membrane proteins
   THUMBUP predicted membrane proteins
   TMHMM predicted membrane proteins
   # TM segments-based
   1TM proteins predicted by MDM
Disease related genes
Potential drug targets
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000139 [Golgi membrane]
GO:0001947 [heart looping]
GO:0003147 [neural crest cell migration involved in heart formation]
GO:0003253 [cardiac neural crest cell migration involved in outflow tract morphogenesis]
GO:0004872 [receptor activity]
GO:0005542 [folic acid binding]
GO:0005634 [nucleus]
GO:0005768 [endosome]
GO:0005789 [endoplasmic reticulum membrane]
GO:0005886 [plasma membrane]
GO:0005887 [integral component of plasma membrane]
GO:0006888 [ER to Golgi vesicle-mediated transport]
GO:0006898 [receptor-mediated endocytosis]
GO:0008144 [drug binding]
GO:0008517 [folic acid transporter activity]
GO:0009986 [cell surface]
GO:0012507 [ER to Golgi transport vesicle membrane]
GO:0015884 [folic acid transport]
GO:0016020 [membrane]
GO:0016323 [basolateral plasma membrane]
GO:0016324 [apical plasma membrane]
GO:0017015 [regulation of transforming growth factor beta receptor signaling pathway]
GO:0018279 [protein N-linked glycosylation via asparagine]
GO:0030136 [clathrin-coated vesicle]
GO:0031103 [axon regeneration]
GO:0031362 [anchored component of external side of plasma membrane]
GO:0033116 [endoplasmic reticulum-Golgi intermediate compartment membrane]
GO:0043687 [post-translational protein modification]
GO:0044267 [cellular protein metabolic process]
GO:0048208 [COPII vesicle coating]
GO:0051870 [methotrexate binding]
GO:0060828 [regulation of canonical Wnt signaling pathway]
GO:0061024 [membrane organization]
GO:0061626 [pharyngeal arch artery morphogenesis]
GO:0061713 [anterior neural tube closure]
GO:0070062 [extracellular exosome]
GO:0071231 [cellular response to folic acid]
Show all
 257 aa
29.8 kDa 		Yes 1

Contact

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.