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PANX1

GENERAL INFORMATION

Gene name

 PANX1

Gene description

 Pannexin 1

Protein class

 Predicted membrane proteins
Transporters

Predicted localization

 Membrane

Number of transcripts

 2
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HUMAN PROTEIN ATLAS INFORMATION

RNA category
TCGA (cancer tissue):Expressed in all
HPA (cell line):Expressed in all
HPA (normal tissue):Expressed in all

Protein evidence

 Evidence at protein level

Protein expression
normal tissue

 Cytoplasmic expression in several tissues.

ANTIBODY IHC RELIABILITY

Data reliability
description

 Antibody staining mainly not consistent with RNA expression data. Pending external verification.

Reliability score

 Uncertain based on 1 antibody.
HPA016930
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PROGNOSTIC SUMMARY
Prognostic marker in renal cancer (unfavourable), lung cancer (unfavourable) and endometrial cancer (unfavourable).
Renal cancer p<0.001
Lung cancer p<0.001
Endometrial cancer p<0.001
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RNA EXPRESSION OVERVIEW
TCGA dataset
RNA cancer category: Expressed in all

PROTEIN EXPRESSION
Colorectal cancer
Breast cancer
Prostate cancer
Lung cancer
Liver cancer

STAINING SUMMARY
HPA016930

GENE INFORMATION

Gene name

 PANX1 (HGNC Symbol)

Synonyms

 MRS1, PX1, UNQ2529

Description

 Pannexin 1 (HGNC Symbol)

Entrez gene summary

 The protein encoded by this gene belongs to the innexin family. Innexin family members are the structural components of gap junctions. This protein and pannexin 2 are abundantly expressed in central nerve system (CNS) and are coexpressed in various neuronal populations. Studies in Xenopus oocytes suggest that this protein alone and in combination with pannexin 2 may form cell type-specific gap junctions with distinct properties. [provided by RefSeq, Jul 2008]

Chromosome

 11

Cytoband

 q21

Chromosome location (bp)

 94128928 - 94181972

Protein evidence

 Evidence at protein level (all genes)

Ensembl

 ENSG00000110218 (version 83.38)

Entrez gene

 24145

UniProt

 Q96RD7 (UniProt - Evidence at protein level)

neXtProt

 NX_Q96RD7

Antibodypedia

 PANX1 antibodies

PROTEIN BROWSER
PANX1-001
PANX1-002

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)
PANX1-001
ENSP00000227638
ENST00000227638
Q96RD7 [Direct mapping]
Pannexin-1
A0A024R397 [Target identity:100%; Query identity:100%]
Pannexin
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Transporters
   Transporter channels and pores
Predicted membrane proteins
   Prediction method-based
   Membrane proteins predicted by MDM
   MEMSAT3 predicted membrane proteins
   MEMSAT-SVM predicted membrane proteins
   Phobius predicted membrane proteins
   SCAMPI predicted membrane proteins
   SPOCTOPUS predicted membrane proteins
   THUMBUP predicted membrane proteins
   TMHMM predicted membrane proteins
   # TM segments-based
   4TM proteins predicted by MDM
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
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GO:0002020 [protease binding]
GO:0002931 [response to ischemia]
GO:0003779 [actin binding]
GO:0005102 [receptor binding]
GO:0005243 [gap junction channel activity]
GO:0005262 [calcium channel activity]
GO:0005515 [protein binding]
GO:0005783 [endoplasmic reticulum]
GO:0005789 [endoplasmic reticulum membrane]
GO:0005886 [plasma membrane]
GO:0005921 [gap junction]
GO:0006812 [cation transport]
GO:0006816 [calcium ion transport]
GO:0007267 [cell-cell signaling]
GO:0007268 [synaptic transmission]
GO:0015267 [channel activity]
GO:0016020 [membrane]
GO:0016021 [integral component of membrane]
GO:0022840 [leak channel activity]
GO:0032059 [bleb]
GO:0033198 [response to ATP]
GO:0034214 [protein hexamerization]
GO:0035872 [nucleotide-binding domain, leucine rich repeat containing receptor signaling pathway]
GO:0043234 [protein complex]
GO:0044325 [ion channel binding]
GO:0045087 [innate immune response]
GO:0046982 [protein heterodimerization activity]
GO:0050715 [positive regulation of cytokine secretion]
GO:0050717 [positive regulation of interleukin-1 alpha secretion]
GO:0050718 [positive regulation of interleukin-1 beta secretion]
GO:0051015 [actin filament binding]
GO:0055077 [gap junction hemi-channel activity]
GO:0055085 [transmembrane transport]
GO:0070588 [calcium ion transmembrane transport]
GO:0097110 [scaffold protein binding]
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 426 aa
48 kDa 		No 4
PANX1-002
ENSP00000411461
ENST00000436171
Q96RD7 [Direct mapping]
Pannexin-1
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Transporters
   Transporter channels and pores
Predicted membrane proteins
   Prediction method-based
   Membrane proteins predicted by MDM
   MEMSAT3 predicted membrane proteins
   MEMSAT-SVM predicted membrane proteins
   Phobius predicted membrane proteins
   SCAMPI predicted membrane proteins
   SPOCTOPUS predicted membrane proteins
   THUMBUP predicted membrane proteins
   TMHMM predicted membrane proteins
   # TM segments-based
   4TM proteins predicted by MDM
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0005102 [receptor binding]
GO:0005262 [calcium channel activity]
GO:0005783 [endoplasmic reticulum]
GO:0005789 [endoplasmic reticulum membrane]
GO:0005886 [plasma membrane]
GO:0005921 [gap junction]
GO:0006812 [cation transport]
GO:0006816 [calcium ion transport]
GO:0007267 [cell-cell signaling]
GO:0007268 [synaptic transmission]
GO:0016020 [membrane]
GO:0016021 [integral component of membrane]
GO:0022840 [leak channel activity]
GO:0032059 [bleb]
GO:0034214 [protein hexamerization]
GO:0035872 [nucleotide-binding domain, leucine rich repeat containing receptor signaling pathway]
GO:0045087 [innate immune response]
GO:0050718 [positive regulation of interleukin-1 beta secretion]
GO:0055077 [gap junction hemi-channel activity]
GO:0070588 [calcium ion transmembrane transport]
Show all
 422 aa
47.6 kDa 		No 4

Contact

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.