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APOA5

GENERAL INFORMATION

Gene name

 APOA5

Gene description

 Apolipoprotein A-V

Protein class

 Disease related genes
Plasma proteins
Predicted secreted proteins

Predicted localization

 Secreted

Number of transcripts

 3
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HUMAN PROTEIN ATLAS INFORMATION

RNA category
TCGA (cancer tissue):Tissue enriched (liver cancer)
HPA (cell line):Cell line enriched (Hep G2)
HPA (normal tissue):Tissue enriched (liver)

Protein evidence

 Evidence at protein level

ANTIBODY IHC RELIABILITY

Reliability score

 Pending cancer tissue analysis.

PROGNOSTIC SUMMARY
Gene product is not prognostic.
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RNA EXPRESSION OVERVIEW
TCGA dataset
RNA cancer category: Tissue enriched (liver cancer)

PROTEIN EXPRESSION

Pending cancer tissue analysis

STAINING SUMMARY

 

GENE INFORMATION

Gene name

 APOA5 (HGNC Symbol)

Synonyms

 APOA-V, RAP3

Description

 Apolipoprotein A-V (HGNC Symbol)

Entrez gene summary

 The protein encoded by this gene is an apolipoprotein that plays an important role in regulating the plasma triglyceride levels, a major risk factor for coronary artery disease. It is a component of high density lipoprotein and is highly similar to a rat protein that is upregulated in response to liver injury. Mutations in this gene have been associated with hypertriglyceridemia and hyperlipoproteinemia type 5. This gene is located proximal to the apolipoprotein gene cluster on chromosome 11q23. Alternatively spliced transcript variants encoding the same protein have been identified. [provided by RefSeq, Oct 2009]

Chromosome

 11

Cytoband

 q23.3

Chromosome location (bp)

 116789367 - 116792420

Protein evidence

 Evidence at protein level (all genes)

Ensembl

 ENSG00000110243 (version 83.38)

Entrez gene

 116519

UniProt

 Q6Q788 (UniProt - Evidence at protein level)

neXtProt

 NX_Q6Q788

Antibodypedia

 APOA5 antibodies

PROTEIN BROWSER
APOA5-001
APOA5-002
APOA5-201

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)
APOA5-001
ENSP00000227665
ENST00000227665
Q6Q788 [Direct mapping]
Apolipoprotein A-V
A0A0B4RUS7 [Target identity:100%; Query identity:100%]
Apolipoprotein A-V, isoform CRA_a; Apolipoprotein A5
Show all
   MEMSAT3 predicted membrane proteins
Predicted secreted proteins
   Secreted proteins predicted by MDSEC
   SignalP predicted secreted proteins
   Phobius predicted secreted proteins
   SPOCTOPUS predicted secreted proteins
Plasma proteins
Disease related genes
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0005543 [phospholipid binding]
GO:0005576 [extracellular region]
GO:0005615 [extracellular space]
GO:0006641 [triglyceride metabolic process]
GO:0006695 [cholesterol biosynthetic process]
GO:0006869 [lipid transport]
GO:0008047 [enzyme activator activity]
GO:0008201 [heparin binding]
GO:0008289 [lipid binding]
GO:0010873 [positive regulation of cholesterol esterification]
GO:0010898 [positive regulation of triglyceride catabolic process]
GO:0010902 [positive regulation of very-low-density lipoprotein particle remodeling]
GO:0015485 [cholesterol binding]
GO:0017127 [cholesterol transporter activity]
GO:0019433 [triglyceride catabolic process]
GO:0019899 [enzyme binding]
GO:0030300 [regulation of intestinal cholesterol absorption]
GO:0031102 [neuron projection regeneration]
GO:0031210 [phosphatidylcholine binding]
GO:0033344 [cholesterol efflux]
GO:0033700 [phospholipid efflux]
GO:0034361 [very-low-density lipoprotein particle]
GO:0034364 [high-density lipoprotein particle]
GO:0034372 [very-low-density lipoprotein particle remodeling]
GO:0034380 [high-density lipoprotein particle assembly]
GO:0035473 [lipase binding]
GO:0042157 [lipoprotein metabolic process]
GO:0042246 [tissue regeneration]
GO:0042627 [chylomicron]
GO:0042632 [cholesterol homeostasis]
GO:0043691 [reverse cholesterol transport]
GO:0044255 [cellular lipid metabolic process]
GO:0044281 [small molecule metabolic process]
GO:0045723 [positive regulation of fatty acid biosynthetic process]
GO:0046470 [phosphatidylcholine metabolic process]
GO:0048260 [positive regulation of receptor-mediated endocytosis]
GO:0050750 [low-density lipoprotein particle receptor binding]
GO:0050996 [positive regulation of lipid catabolic process]
GO:0051006 [positive regulation of lipoprotein lipase activity]
GO:0055090 [acylglycerol homeostasis]
GO:0060228 [phosphatidylcholine-sterol O-acyltransferase activator activity]
GO:0060229 [lipase activator activity]
GO:0060230 [lipoprotein lipase activator activity]
GO:0070325 [lipoprotein particle receptor binding]
GO:0070328 [triglyceride homeostasis]
GO:0072562 [blood microparticle]
Show all
 366 aa
41.2 kDa 		Yes 0
APOA5-002
ENSP00000399701
ENST00000433069
C9JZZ0 [Direct mapping]
Apolipoprotein A-V
Show all
   MEMSAT3 predicted membrane proteins
Predicted secreted proteins
   Secreted proteins predicted by MDSEC
   SignalP predicted secreted proteins
   Phobius predicted secreted proteins
   SPOCTOPUS predicted secreted proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0005576 [extracellular region]
GO:0006695 [cholesterol biosynthetic process]
GO:0006869 [lipid transport]
GO:0008289 [lipid binding]
GO:0010873 [positive regulation of cholesterol esterification]
GO:0015485 [cholesterol binding]
GO:0017127 [cholesterol transporter activity]
GO:0030300 [regulation of intestinal cholesterol absorption]
GO:0031102 [neuron projection regeneration]
GO:0033344 [cholesterol efflux]
GO:0033700 [phospholipid efflux]
GO:0034372 [very-low-density lipoprotein particle remodeling]
GO:0034380 [high-density lipoprotein particle assembly]
GO:0042157 [lipoprotein metabolic process]
GO:0043085 [positive regulation of catalytic activity]
GO:0043691 [reverse cholesterol transport]
GO:0046470 [phosphatidylcholine metabolic process]
GO:0060228 [phosphatidylcholine-sterol O-acyltransferase activator activity]
GO:0072562 [blood microparticle]
Show all
 162 aa
18.5 kDa 		Yes 0
APOA5-201
ENSP00000445002
ENST00000542499
Q6Q788 [Direct mapping]
Apolipoprotein A-V
A0A0B4RUS7 [Target identity:100%; Query identity:100%]
Apolipoprotein A-V, isoform CRA_a; Apolipoprotein A5
Show all
   MEMSAT3 predicted membrane proteins
Predicted secreted proteins
   Secreted proteins predicted by MDSEC
   SignalP predicted secreted proteins
   Phobius predicted secreted proteins
   SPOCTOPUS predicted secreted proteins
Plasma proteins
Disease related genes
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0005543 [phospholipid binding]
GO:0005576 [extracellular region]
GO:0005615 [extracellular space]
GO:0006641 [triglyceride metabolic process]
GO:0006695 [cholesterol biosynthetic process]
GO:0006869 [lipid transport]
GO:0008047 [enzyme activator activity]
GO:0008201 [heparin binding]
GO:0008289 [lipid binding]
GO:0010873 [positive regulation of cholesterol esterification]
GO:0010898 [positive regulation of triglyceride catabolic process]
GO:0010902 [positive regulation of very-low-density lipoprotein particle remodeling]
GO:0015485 [cholesterol binding]
GO:0017127 [cholesterol transporter activity]
GO:0019433 [triglyceride catabolic process]
GO:0019899 [enzyme binding]
GO:0030300 [regulation of intestinal cholesterol absorption]
GO:0031102 [neuron projection regeneration]
GO:0031210 [phosphatidylcholine binding]
GO:0033344 [cholesterol efflux]
GO:0033700 [phospholipid efflux]
GO:0034361 [very-low-density lipoprotein particle]
GO:0034364 [high-density lipoprotein particle]
GO:0034370 [triglyceride-rich lipoprotein particle remodeling]
GO:0034372 [very-low-density lipoprotein particle remodeling]
GO:0034380 [high-density lipoprotein particle assembly]
GO:0035473 [lipase binding]
GO:0042157 [lipoprotein metabolic process]
GO:0042246 [tissue regeneration]
GO:0042627 [chylomicron]
GO:0042632 [cholesterol homeostasis]
GO:0043691 [reverse cholesterol transport]
GO:0044255 [cellular lipid metabolic process]
GO:0044281 [small molecule metabolic process]
GO:0045723 [positive regulation of fatty acid biosynthetic process]
GO:0046470 [phosphatidylcholine metabolic process]
GO:0048260 [positive regulation of receptor-mediated endocytosis]
GO:0050750 [low-density lipoprotein particle receptor binding]
GO:0050996 [positive regulation of lipid catabolic process]
GO:0051006 [positive regulation of lipoprotein lipase activity]
GO:0055090 [acylglycerol homeostasis]
GO:0060228 [phosphatidylcholine-sterol O-acyltransferase activator activity]
GO:0060229 [lipase activator activity]
GO:0060230 [lipoprotein lipase activator activity]
GO:0070325 [lipoprotein particle receptor binding]
GO:0070328 [triglyceride homeostasis]
GO:0072562 [blood microparticle]
Show all
 366 aa
41.2 kDa 		Yes 0

Contact

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.