Expression of HIPK3 in cancer - Summary - The Human Protein Atlas

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HIPK3

TISSUE

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CELL

PATHOLOGY

PATHOLOGY ATLAS

GENE/PROTEIN

Antibody validation

Dictionary


Level of antibody staining/expression
	High Medium Low Not detected

GENERAL INFORMATION
Gene name	HIPK3
Gene description	Homeodomain interacting protein kinase 3
Protein class	Enzymes Predicted intracellular proteins Predicted membrane proteins
Predicted localization	Intracellular,Membrane
Number of transcripts	5
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HUMAN PROTEIN ATLAS INFORMATION

RNA category

TCGA (cancer tissue):	Expressed in all
HPA (cell line):	Expressed in all
HPA (normal tissue):	Expressed in all

Protein evidence

Evidence at protein level

Protein expression
normal tissue

Cytoplasmic and nuclear expression in most tissues.

ANTIBODY IHC RELIABILITY
Data reliability description	Antibody staining mainly not consistent with RNA expression data.
Reliability score	Approved based on 1 antibody. HPA028069
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PROGNOSTIC SUMMARY
Gene product is not prognostic.
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RNA EXPRESSION OVERVIEW
TCGA dataset RNA cancer category: Expressed in all

PROTEIN EXPRESSION

Colorectal cancer

Prostate cancer

STAINING SUMMARY

HPA028069

GENE INFORMATION
Gene name	HIPK3 (HGNC Symbol)
Synonyms	DYRK6, FIST3, PKY, YAK1
Description	Homeodomain interacting protein kinase 3 (HGNC Symbol)
Entrez gene summary
Chromosome	11
Cytoband	p13
Chromosome location (bp)	33256672 - 33357023
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000110422 (version 83.38)
Entrez gene	10114
UniProt	Q9H422 (UniProt - Evidence at protein level)
neXtProt	NX_Q9H422
Antibodypedia	HIPK3 antibodies

PROTEIN BROWSER

HIPK3-001	HIPK3-002	HIPK3-003	HIPK3-004	HIPK3-201

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
HIPK3-001 ENSP00000304226 ENST00000303296	Q9H422 [Direct mapping] Homeodomain-interacting protein kinase 3 Show all	Enzymes ENZYME proteins Transferases Kinases CMGC Ser/Thr protein kinases MEMSAT-SVM predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins Predicted intracellular proteins Protein evidence (Kim et al 2014) Show all	GO:0004672 [protein kinase activity] GO:0004674 [protein serine/threonine kinase activity] GO:0005515 [protein binding] GO:0005524 [ATP binding] GO:0005634 [nucleus] GO:0005737 [cytoplasm] GO:0006355 [regulation of transcription, DNA-templated] GO:0006468 [protein phosphorylation] GO:0006915 [apoptotic process] GO:0009299 [mRNA transcription] GO:0016605 [PML body] GO:0018105 [peptidyl-serine phosphorylation] GO:0018107 [peptidyl-threonine phosphorylation] GO:0043066 [negative regulation of apoptotic process] GO:0043508 [negative regulation of JUN kinase activity] Show all	1215 aa 133.7 kDa	No	0
HIPK3-002 ENSP00000368301 ENST00000379016	Q9H422 [Direct mapping] Homeodomain-interacting protein kinase 3 Show all	Enzymes ENZYME proteins Transferases Kinases CMGC Ser/Thr protein kinases MEMSAT-SVM predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins Predicted intracellular proteins Protein evidence (Kim et al 2014) Show all	GO:0004672 [protein kinase activity] GO:0004674 [protein serine/threonine kinase activity] GO:0005524 [ATP binding] GO:0005634 [nucleus] GO:0005737 [cytoplasm] GO:0006355 [regulation of transcription, DNA-templated] GO:0006468 [protein phosphorylation] GO:0006915 [apoptotic process] GO:0009299 [mRNA transcription] GO:0018105 [peptidyl-serine phosphorylation] GO:0018107 [peptidyl-threonine phosphorylation] GO:0043066 [negative regulation of apoptotic process] GO:0043508 [negative regulation of JUN kinase activity] Show all	1194 aa 131.3 kDa	No	0
HIPK3-003 ENSP00000431710 ENST00000525975	Q9H422 [Direct mapping] Homeodomain-interacting protein kinase 3 Show all	Enzymes ENZYME proteins Transferases Kinases CMGC Ser/Thr protein kinases Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins # TM segments-based 1TM proteins predicted by MDM Show all	GO:0004672 [protein kinase activity] GO:0004674 [protein serine/threonine kinase activity] GO:0005524 [ATP binding] GO:0005634 [nucleus] GO:0005737 [cytoplasm] GO:0006355 [regulation of transcription, DNA-templated] GO:0006468 [protein phosphorylation] GO:0006915 [apoptotic process] GO:0009299 [mRNA transcription] GO:0018105 [peptidyl-serine phosphorylation] GO:0018107 [peptidyl-threonine phosphorylation] GO:0043066 [negative regulation of apoptotic process] GO:0043508 [negative regulation of JUN kinase activity] Show all	1194 aa 131.3 kDa	No	1
HIPK3-004 ENSP00000433594 ENST00000531504	E9PKD7 [Direct mapping] Homeodomain-interacting protein kinase 3 Show all	Predicted intracellular proteins Show all		76 aa 8.7 kDa	No	0
HIPK3-201 ENSP00000398241 ENST00000456517	Q9H422 [Direct mapping] Homeodomain-interacting protein kinase 3 Show all	Enzymes ENZYME proteins Transferases Kinases CMGC Ser/Thr protein kinases Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins # TM segments-based 1TM proteins predicted by MDM Show all	GO:0004672 [protein kinase activity] GO:0004674 [protein serine/threonine kinase activity] GO:0005524 [ATP binding] GO:0005634 [nucleus] GO:0005737 [cytoplasm] GO:0006355 [regulation of transcription, DNA-templated] GO:0006468 [protein phosphorylation] GO:0006915 [apoptotic process] GO:0009299 [mRNA transcription] GO:0018105 [peptidyl-serine phosphorylation] GO:0018107 [peptidyl-threonine phosphorylation] GO:0043066 [negative regulation of apoptotic process] GO:0043508 [negative regulation of JUN kinase activity] Show all	1194 aa 131.3 kDa	No	1

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The Human Protein Atlas

The Human Protein Atlas project is funded
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