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SLC1A2

GENERAL INFORMATION

Gene name

 SLC1A2

Gene description

 Solute carrier family 1 (glial high affinity glutamate transporter), member 2

Protein class

 Predicted intracellular proteins
Predicted membrane proteins
Transporters

Predicted localization

 Intracellular,Membrane

Number of transcripts

 7
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HUMAN PROTEIN ATLAS INFORMATION

RNA tissue category
HPA:Tissue enriched (cerebral cortex)
GTEx:Tissue enhanced (caudate, cerebral cortex)
FANTOM5:Group enriched (brain, caudate, hippocampus)

Protein evidence

 Evidence at protein level

Protein expression

 Distinct expression in astrocytes.

DATA RELIABILITY

Data reliability
description

 Antibody staining mainly consistent with RNA expression data.

Reliability score

 Supported based on 2 antibodies.
HPA009172 , CAB002574
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RNA AND PROTEIN EXPRESSION SUMMARY
RNA expression (TPM) Protein expression (score)
Brain
Caudate
N/A
Endocrine tissues
Bone marrow & immune system
Muscle tissues
Lung
Bronchus
N/A
Liver & gallbladder
Pancreas
Gastrointestinal tract
Kidney & urinary bladder
Male tissues
Female tissues
Vagina
N/A
Adipose & soft tissue
Skin
Cerebral cortex

Hippocampus

Lymph node

Liver

Colon

Kidney

Testis

PROTEIN EXPRESSION OVERVIEW
Organ
Expression
Alphabetical

RNA EXPRESSION OVERVIEW
HPA dataset
Organ
Expression
Alphabetical
RNA tissue category: Tissue enriched (cerebral cortex)
GTEx dataset
Organ
Expression
Alphabetical
RNA tissue category: Tissue enhanced (caudate, cerebral cortex)
FANTOM5 dataset
Organ
Expression
Alphabetical
RNA tissue category: Group enriched (brain, caudate, hippocampus)

GENE INFORMATION

Gene name

 SLC1A2 (HGNC Symbol)

Synonyms

 EAAT2, GLT-1

Description

 Solute carrier family 1 (glial high affinity glutamate transporter), member 2 (HGNC Symbol)

Entrez gene summary

 This gene encodes a member of a family of solute transporter proteins. The membrane-bound protein is the principal transporter that clears the excitatory neurotransmitter glutamate from the extracellular space at synapses in the central nervous system. Glutamate clearance is necessary for proper synaptic activation and to prevent neuronal damage from excessive activation of glutamate receptors. Mutations in and decreased expression of this protein are associated with amyotrophic lateral sclerosis. Alternatively spliced transcript variants of this gene have been identified. [provided by RefSeq, Sep 2010]

Chromosome

 11

Cytoband

 p13

Chromosome location (bp)

 35251206 - 35420063

Protein evidence

 Evidence at protein level (all genes)

Ensembl

 ENSG00000110436 (version 83.38)

Entrez gene

 6506

UniProt

 P43004 (UniProt - Evidence at protein level)

neXtProt

 NX_P43004

Antibodypedia

 SLC1A2 antibodies

PROTEIN BROWSER
SLC1A2-001
SLC1A2-002
SLC1A2-003
SLC1A2-004
SLC1A2-006
SLC1A2-007
SLC1A2-008

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)
SLC1A2-001
ENSP00000278379
ENST00000278379
P43004 [Direct mapping]
Excitatory amino acid transporter 2
Show all
Transporters
   Electrochemical Potential-driven transporters
Predicted membrane proteins
   Prediction method-based
   Membrane proteins predicted by MDM
   MEMSAT3 predicted membrane proteins
   MEMSAT-SVM predicted membrane proteins
   Phobius predicted membrane proteins
   SCAMPI predicted membrane proteins
   SPOCTOPUS predicted membrane proteins
   THUMBUP predicted membrane proteins
   TMHMM predicted membrane proteins
   # TM segments-based
   >9TM proteins predicted by MDM
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0005313 [L-glutamate transmembrane transporter activity]
GO:0005515 [protein binding]
GO:0005886 [plasma membrane]
GO:0006811 [ion transport]
GO:0006835 [dicarboxylic acid transport]
GO:0007268 [synaptic transmission]
GO:0007269 [neurotransmitter secretion]
GO:0007399 [nervous system development]
GO:0007632 [visual behavior]
GO:0009416 [response to light stimulus]
GO:0009611 [response to wounding]
GO:0009986 [cell surface]
GO:0010259 [multicellular organismal aging]
GO:0014047 [glutamate secretion]
GO:0015501 [glutamate:sodium symporter activity]
GO:0015813 [L-glutamate transport]
GO:0016020 [membrane]
GO:0016021 [integral component of membrane]
GO:0017153 [sodium:dicarboxylate symporter activity]
GO:0021537 [telencephalon development]
GO:0030424 [axon]
GO:0030534 [adult behavior]
GO:0030673 [axolemma]
GO:0031668 [cellular response to extracellular stimulus]
GO:0035264 [multicellular organism growth]
GO:0042493 [response to drug]
GO:0043200 [response to amino acid]
GO:0046326 [positive regulation of glucose import]
GO:0051938 [L-glutamate import]
GO:0055085 [transmembrane transport]
GO:0070779 [D-aspartate import]
GO:0089711 [L-glutamate transmembrane transport]
Show all
 574 aa
62.1 kDa 		No >9
SLC1A2-002
ENSP00000379102
ENST00000395753
P43004 [Direct mapping]
Excitatory amino acid transporter 2
A2A2U1 [Target identity:100%; Query identity:100%]
Amino acid transporter
Show all
Transporters
   Electrochemical Potential-driven transporters
Predicted membrane proteins
   Prediction method-based
   Membrane proteins predicted by MDM
   MEMSAT3 predicted membrane proteins
   MEMSAT-SVM predicted membrane proteins
   Phobius predicted membrane proteins
   SCAMPI predicted membrane proteins
   SPOCTOPUS predicted membrane proteins
   THUMBUP predicted membrane proteins
   TMHMM predicted membrane proteins
   # TM segments-based
   >9TM proteins predicted by MDM
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0005313 [L-glutamate transmembrane transporter activity]
GO:0005515 [protein binding]
GO:0005886 [plasma membrane]
GO:0006811 [ion transport]
GO:0006835 [dicarboxylic acid transport]
GO:0007268 [synaptic transmission]
GO:0007269 [neurotransmitter secretion]
GO:0009986 [cell surface]
GO:0014047 [glutamate secretion]
GO:0016020 [membrane]
GO:0016021 [integral component of membrane]
GO:0017153 [sodium:dicarboxylate symporter activity]
GO:0051938 [L-glutamate import]
GO:0055085 [transmembrane transport]
GO:0070779 [D-aspartate import]
GO:0089711 [L-glutamate transmembrane transport]
Show all
 565 aa
61.2 kDa 		No >9
SLC1A2-003
ENSP00000435406
ENST00000464522
H0YEB1 [Direct mapping]
Excitatory amino acid transporter 2
Show all
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0006835 [dicarboxylic acid transport]
GO:0016020 [membrane]
GO:0017153 [sodium:dicarboxylate symporter activity]
Show all
 91 aa
10.1 kDa 		No 0
SLC1A2-004
ENSP00000379099
ENST00000395750
P43004 [Direct mapping]
Excitatory amino acid transporter 2
A2A2U1 [Target identity:100%; Query identity:100%]
Amino acid transporter
Show all
Transporters
   Electrochemical Potential-driven transporters
Predicted membrane proteins
   Prediction method-based
   Membrane proteins predicted by MDM
   MEMSAT3 predicted membrane proteins
   MEMSAT-SVM predicted membrane proteins
   Phobius predicted membrane proteins
   SCAMPI predicted membrane proteins
   SPOCTOPUS predicted membrane proteins
   THUMBUP predicted membrane proteins
   TMHMM predicted membrane proteins
   # TM segments-based
   >9TM proteins predicted by MDM
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0005313 [L-glutamate transmembrane transporter activity]
GO:0005515 [protein binding]
GO:0005886 [plasma membrane]
GO:0006811 [ion transport]
GO:0006835 [dicarboxylic acid transport]
GO:0007268 [synaptic transmission]
GO:0007269 [neurotransmitter secretion]
GO:0009986 [cell surface]
GO:0014047 [glutamate secretion]
GO:0016020 [membrane]
GO:0016021 [integral component of membrane]
GO:0017153 [sodium:dicarboxylate symporter activity]
GO:0051938 [L-glutamate import]
GO:0055085 [transmembrane transport]
GO:0070779 [D-aspartate import]
GO:0089711 [L-glutamate transmembrane transport]
Show all
 565 aa
61.2 kDa 		No >9
SLC1A2-006
ENSP00000406133
ENST00000449068
C9J9N5 [Direct mapping]
Amino acid transporter
Show all
Predicted membrane proteins
   Prediction method-based
   Membrane proteins predicted by MDM
   MEMSAT3 predicted membrane proteins
   MEMSAT-SVM predicted membrane proteins
   Phobius predicted membrane proteins
   SCAMPI predicted membrane proteins
   SPOCTOPUS predicted membrane proteins
   THUMBUP predicted membrane proteins
   TMHMM predicted membrane proteins
   # TM segments-based
   3TM proteins predicted by MDM
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0006835 [dicarboxylic acid transport]
GO:0016020 [membrane]
GO:0016021 [integral component of membrane]
GO:0017153 [sodium:dicarboxylate symporter activity]
GO:0055085 [transmembrane transport]
Show all
 199 aa
21.5 kDa 		No 3
SLC1A2-007
ENSP00000436029
ENST00000531628
H0YEK4 [Direct mapping]
Amino acid transporter
Show all
Predicted membrane proteins
   Prediction method-based
   Membrane proteins predicted by MDM
   MEMSAT3 predicted membrane proteins
   MEMSAT-SVM predicted membrane proteins
   Phobius predicted membrane proteins
   SCAMPI predicted membrane proteins
   SPOCTOPUS predicted membrane proteins
   THUMBUP predicted membrane proteins
   TMHMM predicted membrane proteins
   # TM segments-based
   3TM proteins predicted by MDM
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0006835 [dicarboxylic acid transport]
GO:0016020 [membrane]
GO:0016021 [integral component of membrane]
GO:0017153 [sodium:dicarboxylate symporter activity]
GO:0055085 [transmembrane transport]
Show all
 199 aa
21.7 kDa 		No 3
SLC1A2-008
ENSP00000476124
ENST00000606205
P43004 [Direct mapping]
Excitatory amino acid transporter 2
Show all
Transporters
   Electrochemical Potential-driven transporters
Predicted membrane proteins
   Prediction method-based
   Membrane proteins predicted by MDM
   MEMSAT3 predicted membrane proteins
   MEMSAT-SVM predicted membrane proteins
   Phobius predicted membrane proteins
   SCAMPI predicted membrane proteins
   SPOCTOPUS predicted membrane proteins
   THUMBUP predicted membrane proteins
   TMHMM predicted membrane proteins
   # TM segments-based
   >9TM proteins predicted by MDM
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0005313 [L-glutamate transmembrane transporter activity]
GO:0005515 [protein binding]
GO:0005886 [plasma membrane]
GO:0006811 [ion transport]
GO:0006835 [dicarboxylic acid transport]
GO:0007268 [synaptic transmission]
GO:0007269 [neurotransmitter secretion]
GO:0009986 [cell surface]
GO:0014047 [glutamate secretion]
GO:0016020 [membrane]
GO:0016021 [integral component of membrane]
GO:0017153 [sodium:dicarboxylate symporter activity]
GO:0051938 [L-glutamate import]
GO:0055085 [transmembrane transport]
GO:0070779 [D-aspartate import]
GO:0089711 [L-glutamate transmembrane transport]
Show all
 563 aa
61 kDa 		No >9

Contact

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.